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公开(公告)号：US10385036B2
公开(公告)日：2019-08-20
申请号：US15547228
申请日：2016-01-29
申请人： Pfizer Inc.
发明人： Mark Edward Schnute , Andrew Christopher Flick , Peter Jones , Neelu Kaila , Scot Richard Mente , John David Trzupek , Michael L. Vazquez , Goran Mattias Wennerstal , Li Xing , Edouard Zamaratski , Liying Zhang , Rayomand J. Unwalla
IPC分类号： C07D401/04 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14
摘要： The present invention provides sulfonamide-substituted indoles and Methods of Use Thereof-substituted pyrrolopyridines, pharmaceutical compositions thereof methods of modulating RORy activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such indoles and pharmaceutical compositions thereof.
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公开(公告)号：US20180273504A1
公开(公告)日：2018-09-27
申请号：US15547228
申请日：2016-01-29
申请人： Pfizer Inc.
发明人： Mark Edward Schnute , Andrew Christopher Flick , Peter Jones , Neelu Kaila , Scot Richard Mente , John David Trzupek , Michael L. Vazquez , Goran Mattias Wennerstal , Li Xing , Edouard Zamaratski , Liying Zhang , Rayomand J. Unwalla
IPC分类号： C07D401/04 , A61P29/00 , A61P37/06 , C07D401/14 , C07D417/14 , C07D405/14 , C07D413/14
CPC分类号： C07D401/04 , A61P29/00 , A61P37/06 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14
摘要： The present invention provides sulfonamide-substituted indoles and Methods of Use Thereof-substituted pyrro-lopyridines, pharmaceutical compositions thereof methods of modulating RORy activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such indoles and pharmaceutical compositions thereof.
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公开(公告)号：US10426135B2
公开(公告)日：2019-10-01
申请号：US16268857
申请日：2019-02-06
申请人： Pfizer Inc.
发明人： Mark Edward Schnute , Andrew Christopher Flick , Peter Jones , Neelu Kaila , Scot Richard Mente , John David Trzupek , Michael L. Vazquez , Goran Mattias Wennerstal , Li Xing , Edouard Zamaratski , Liying Zhang , Rayomand Jal Unwalla
IPC分类号： C07D401/02 , C07D401/10 , A61K31/437 , A61K31/4353 , A01K5/01 , B65D77/20 , B65D25/04 , B65D1/34 , A01K7/00 , A23K20/00 , A23K50/48 , B65D1/36 , B65D25/18 , B65D85/00
摘要： The present invention provides methyl- and trifluoromethyl-substituted pyrrolopyridines, pharmaceutical compositions thereof, methods of modulating RORγ activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such pyrrolopyridines and pharmaceutical compositions thereof.
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4.发明申请公开(公告)号：US20190387710A1
公开(公告)日：2019-12-26
申请号：US16563022
申请日：2019-09-06
申请人： Pfizer Inc.
发明人： Mark Edward Schnute , Andrew Christopher Flick , Peter Jones , Neelu Kaila , Scot Richard Mente , John David Trzupek , Michael L. Vazquez , Goran Mattias Wennerstal , Li Xing , Edouard Zamaratski , Liying Zhang , Rayomand Jal Unwalla
IPC分类号： A01K5/01 , B65D25/18 , B65D25/04 , B65D1/36 , B65D1/34 , A01K7/00 , B65D77/20 , A23K20/00 , A23K50/48 , C07D471/04 , C07D401/14
摘要： The present invention provides methyl- and trifluoromethyl-substituted pyrrolopyridines, pharmaceutical compositions thereof, methods of modulating RORγ activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such pyrrolopyridines and pharmaceutical compositions thereof.
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公开(公告)号：US10336748B2
公开(公告)日：2019-07-02
申请号：US15546887
申请日：2016-01-29
申请人： Pfizer Inc.
发明人： Mark Edward Schnute , Andrew Christopher Flick , Peter Jones , Neelu Kaila , Scot Richard Mente , John David Trzupek , Michael L. Vazquez , Goran Mattias Wennerstal , Li Xing , Edouard Zamaratski , Liying Zhang , Rayomand J. Unwalla
IPC分类号： C07D471/04
摘要： The present invention provides methoxy-substituted pyrrolopyridines, pharmaceutical compositions thereof, methods of modulating RORγ activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such pyrrolopyridines and pharmaceutical compositions thereof.
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6.发明申请公开(公告)号：US20190150401A1
公开(公告)日：2019-05-23
申请号：US16268857
申请日：2019-02-06
申请人： Pfizer Inc.
发明人： Mark Edward Schnute , Andrew Christopher Flick , Peter Jones , Neelu Kaila , Scot Richard Mente , John David Trzupek , Michael L. Vazquez , Goran Mattias Wennerstal , Li Xing , Edouard Zamaratski , Liying Zhang , Rayomand Jal Unwalla
IPC分类号： A01K5/01 , B65D77/20 , B65D25/04 , B65D1/34 , A01K7/00 , B65D25/18 , A23K20/00 , A23K50/48 , B65D1/36
CPC分类号： A01K5/0121 , A01K7/00 , A23K20/00 , A23K50/48 , B65D1/34 , B65D1/36 , B65D25/04 , B65D25/18 , B65D77/2024 , B65D85/70 , B65D2577/205 , C07D401/14 , C07D471/04
摘要： The present invention provides methyl- and trifluoromethyl-substituted pyrrolopyridines, pharmaceutical compositions thereof, methods of modulating RORγ activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such pyrrolopyridines and pharmaceutical compositions thereof.
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公开(公告)号：US10227346B2
公开(公告)日：2019-03-12
申请号：US15889296
申请日：2018-02-06
申请人： Pfizer Inc.
发明人： Mark Edward Schnute , Andrew Christopher Flick , Peter Jones , Neelu Kaila , Scot Richard Mente , John David Trzupek , Michael L. Vazquez , Goran Mattias Wennerstal , Li Xing , Edouard Zamaratski , Liying Zhang , Rayomand Jal Unwalla
IPC分类号： A61K31/437 , A61K31/4353 , C07D471/04 , C07D401/14
摘要： The present invention provides methyl- and trifluoromethyl-substituted pyrrolopyridines, pharmaceutical compositions thereof, methods of modulating RORγ activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such pyrrolopyridines and pharmaceutical compositions thereof.
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公开(公告)号：US20180002330A1
公开(公告)日：2018-01-04
申请号：US15546887
申请日：2016-01-29
申请人： Pfizer Inc.
发明人： Mark Edward Schnute , Andrew Christopher Flick , Peter Jones , Neelu Kaila , Scot Richard Mente , John David Trzupek , Michael L. Vazquez , Goran Mattias Wennerstal , Li Xing , Edouard Zamaratski , Liying Zhang , Rayomand J. Unwalla
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： The present invention provides methoxy-substituted pyrrolopyridines, pharmaceutical compositions thereof, methods of modulating RORγ activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such pyrrolopyridines and pharmaceutical compositions thereof.
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