公开(公告)号：US20150291554A1

公开(公告)日：2015-10-15

申请号：US14439478

申请日：2013-11-01

申请人： PFIZER INC.

发明人： John Robert Springer ,  Balekudru Devadas ,  Danny James Garland ,  Margaret Lanahan Grapperhaus ,  Seungil Han ,  Susan Landis Hockerman ,  Robert Owen Hughes ,  Eddine Saiah ,  Mark Edward Schnute ,  Shaun Raj Selness ,  Daniel Patrick Walker ,  Zhao-Kui Wan ,  Li Xing ,  Christoph Wolfgang Zapf ,  Michelle Ann Schmidt

IPC分类号： C07D401/04

CPC分类号： C07D401/04

摘要： Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (BTK). Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the BTK inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.

摘要翻译： 本文公开的是与布鲁顿酪氨酸激酶（BTK）形成共价键的化合物。 公开了制备化合物的方法。 还公开了包含化合物的药物组合物。 公开了使用BTK抑制剂的方法，单独或与其它治疗剂组合用于治疗自身免疫性疾病或病症，异种免疫性疾病或病症，癌症，包括淋巴瘤和炎性疾病或病症。

公开(公告)号：US20190202798A1

公开(公告)日：2019-07-04

申请号：US16296319

申请日：2019-03-08

申请人： Pfizer Inc.

发明人： John Robert Springer ,  Balekudru Devadas ,  Danny James Garland ,  Margaret Lanahan Grapperhaus ,  Seungil Han ,  Susan Landis Hockerman ,  Robert Owen Hughes ,  Eddine Saiah ,  Mark Edward Schnute ,  Shaun Raj Selness ,  Daniel Patrick Walker ,  Zhao-Kui Wan ,  Li Xing ,  Christoph Wolfgang Zapf ,  Michelle Ann Schmidt

IPC分类号： C07D401/04

摘要： Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (BTK). Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the BTK inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases cases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions. (Formula I)

公开(公告)号：US20210002251A1

公开(公告)日：2021-01-07

申请号：US17025026

申请日：2020-09-18

申请人： Pfizer Inc.

发明人： John Robert Springer ,  Balekudru Devadas ,  Danny James Garland ,  Margaret Lanahan Grapperhaus ,  Seungil Han ,  Susan Landis Hockerman ,  Robert Owen Hughes ,  Eddine Saiah ,  Mark Edward Schnute ,  Shaun Raj Selness ,  Daniel Patrick Walker ,  Zhao-Kui Wan ,  Li Xing ,  Christoph Wolfgang Zapf ,  Michelle Ann Schmidt

IPC分类号： C07D401/04

摘要： Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (BTK). Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the BTK inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions. (Formula I)

公开(公告)号：US10266513B2

公开(公告)日：2019-04-23

申请号：US15624969

申请日：2017-06-16

申请人： Pfizer Inc.

发明人： John Robert Springer ,  Balekudru Devadas ,  Danny James Garland ,  Margaret Lanahan Grapperhaus ,  Seungil Han ,  Susan Landis Hockerman ,  Robert Owen Hughes ,  Eddine Saiah ,  Mark Edward Schnute ,  Shaun Raj Selness ,  Daniel Patrick Walker ,  Zhao-Kui Wan ,  Li Xing ,  Christoph Wolfgang Zapf ,  Michelle Ann Schmidt

IPC分类号： C07D403/04 ,  C07D401/04

摘要： Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (BTK). Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the BTK inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseeases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.

公开(公告)号：US10815213B2

公开(公告)日：2020-10-27

申请号：US16296319

申请日：2019-03-08

申请人： Pfizer Inc.

发明人： John Robert Springer ,  Balekudru Devadas ,  Danny James Garland ,  Margaret Lanahan Grapperhaus ,  Seungil Han ,  Susan Landis Hockerman ,  Robert Owen Hughes ,  Eddine Saiah ,  Mark Edward Schnute ,  Shaun Raj Selness ,  Daniel Patrick Walker ,  Zhao-Kui Wan ,  Li Xing ,  Christoph Wolfgang Zapf ,  Michelle Ann Schmidt

IPC分类号： C07D401/04 ,  C07D401/14 ,  A61K31/4155 ,  A61K31/454 ,  A61P29/00 ,  A61P35/00

摘要： Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (BTK). Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the BTK inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions. (Formula I)

公开(公告)号：US20170283393A1

公开(公告)日：2017-10-05

申请号：US15624969

申请日：2017-06-16

申请人： Pfizer Inc.

发明人： John Robert Springer ,  Balekudru Devadas ,  Danny James Garland ,  Margaret Lanahan Grapperhaus ,  Seungil Han ,  Susan Landis Hockerman ,  Robert Owen Hughes ,  Eddine Saiah ,  Mark Edward Schnute ,  Shaun Raj Selness ,  Daniel Patrick Walker ,  Zhao-Kui Wan ,  Li Xing ,  Christoph Wolfgang Zapf ,  Michelle Ann Schmidt

IPC分类号： C07D401/04

CPC分类号： C07D401/04

摘要： Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (BTK). Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the BTK inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseeases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.