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公开(公告)号：US20090155301A1
公开(公告)日：2009-06-18
申请号：US11711532
申请日：2007-02-27
申请人： Peter W. Mason , Elena Frolova , Ilya Frolov
发明人： Peter W. Mason , Elena Frolova , Ilya Frolov
CPC分类号： C12N7/00 , A61K39/12 , A61K2039/5254 , C12N2770/24134 , C12N2770/24162 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396
摘要： The present invention discloses a replication-deficient pseudoinfective virus belonging to the Flaviviridae family that lack the capsid gene, where the replication-deficient pseudoinfective virus propagates only in cells expressing the capsid or capsid, prM and envelope protein of the flavivirus. The present also discloses the method of producing such viruses on a large scale and the use of these pseudoinfective viruses as vaccines for preventing diseases caused by infections of humans or animals by the viruses belonging to this family.
摘要翻译： 本发明公开了属于黄病毒科的复制缺陷型假性感染病毒，其缺乏衣壳基因，其中复制缺陷型假病毒病毒仅在表达黄病毒的衣壳或衣壳，prM和包膜蛋白的细胞中繁殖。 本发明还公开了大规模生产这种病毒的方法，以及这些假感染性病毒作为疫苗用于预防由该家族的病毒感染人或动物引起的疾病的疫苗。
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公开(公告)号：US09273288B2
公开(公告)日：2016-03-01
申请号：US13561002
申请日：2012-07-28
申请人： Peter W. Mason , Elena Frolova , Ilya Frolov
发明人： Peter W. Mason , Elena Frolova , Ilya Frolov
CPC分类号： C12N7/00 , A61K39/12 , A61K2039/5254 , C12N2770/24134 , C12N2770/24162 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396
摘要： The present invention discloses a replication-deficient pseudoinfective virus belonging to the Flaviviridae family that lack the capsid gene, where the replication-deficient pseudoinfective virus propagates only in cells expressing the capsid or capsid, prM and envelope protein of the flavivirus. The present also discloses the method of producing such viruses on a large scale and the use of these pseudoinfective viruses as vaccines for preventing diseases caused by infections of humans or animals by the viruses belonging to this family.
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公开(公告)号：US20130023031A1
公开(公告)日：2013-01-24
申请号：US13561002
申请日：2012-07-28
申请人： Peter W. Mason , Elena Frolova , Ilya Frolov
发明人： Peter W. Mason , Elena Frolova , Ilya Frolov
CPC分类号： C12N7/00 , A61K39/12 , A61K2039/5254 , C12N2770/24134 , C12N2770/24162 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396
摘要： The present invention discloses a replication-deficient pseudoinfective virus belonging to the Flaviviridae family that lack the capsid gene, where the replication-deficient pseudoinfective virus propagates only in cells expressing the capsid or capsid, prM and envelope protein of the flavivirus. The present also discloses the method of producing such viruses on a large scale and the use of these pseudoinfective viruses as vaccines for preventing diseases caused by infections of humans or animals by the viruses belonging to this family.
摘要翻译： 本发明公开了属于黄病毒科的复制缺陷型假性感染病毒，其缺乏衣壳基因，其中复制缺陷型假病毒病毒仅在表达黄病毒的衣壳或衣壳，prM和包膜蛋白的细胞中繁殖。 本发明还公开了大规模生产这种病毒的方法，以及这些假感染性病毒作为疫苗用于预防由该家族的病毒感染人或动物引起的疾病的疫苗。
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公开(公告)号：US08252574B2
公开(公告)日：2012-08-28
申请号：US11711532
申请日：2007-02-27
申请人： Peter W. Mason , Elena Frolova , Ilya Frolov
发明人： Peter W. Mason , Elena Frolova , Ilya Frolov
CPC分类号： C12N7/00 , A61K39/12 , A61K2039/5254 , C12N2770/24134 , C12N2770/24162 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396
摘要： The present invention discloses a replication-deficient pseudoinfective virus belonging to the Flaviviridae family that lack the capsid gene, where the replication-deficient pseudoinfective virus propagates only in cells expressing the capsid or capsid, prM and envelope protein of the flavivirus. The present also discloses the method of producing such viruses on a large scale and the use of these pseudoinfective viruses as vaccines for preventing diseases caused by infections of humans or animals by the viruses belonging to this family.
摘要翻译： 本发明公开了属于黄病毒科的复制缺陷型假性感染病毒，其缺乏衣壳基因，其中复制缺陷型假病毒病毒仅在表达黄病毒的衣壳或衣壳，prM和包膜蛋白的细胞中繁殖。 本发明还公开了大规模生产这种病毒的方法，以及这些假感染性病毒作为疫苗用于预防由该家族的病毒感染人或动物引起的疾病的疫苗。
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5.发明授权Flaviviruses expressing the prM, E, and NS1 proteins of other flaviviruses and uses thereof 有权表达其他黄病毒的prM，E和NS1蛋白的黄病毒及其用途公开(公告)号：US09499588B2
公开(公告)日：2016-11-22
申请号：US13136081
申请日：2011-07-22
申请人： Peter W. Mason , Tomohiro Ishikawa
发明人： Peter W. Mason , Tomohiro Ishikawa
IPC分类号： C12N7/00 , C07K14/005 , A61K39/00
CPC分类号： C07K14/005 , A61K2039/5254 , A61K2039/5256 , A61K2039/555 , C12N7/00 , C12N2770/24122 , C12N2770/24143 , C12N2770/24161 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394
摘要： This invention provides flavivirus vaccines that comprise live-attenuated flaviviruses and methods of making and using these vaccines. The flavivirus vaccines described herein possess higher potency due to in situ production of additional immunogens in a way that mimics viral infection and the vaccines have potential for higher potency, reducing costs for production and delivery.
摘要翻译： 本发明提供了包含活的减毒黄病毒的黄病毒疫苗以及制备和使用这些疫苗的方法。 本文描述的黄病毒疫苗由于以模拟病毒感染的方式原位产生另外的免疫原而具有更高的效力，并且疫苗具有更高效力的潜力，降低了生产和递送的成本。
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公开(公告)号：US5866416A
公开(公告)日：1999-02-02
申请号：US593999
申请日：1996-06-24
IPC分类号： A61K39/00 , C07K14/09 , C07K14/705 , A61K39/135 , C07H21/04 , C12N5/10
CPC分类号： C07K14/005 , C07K14/70525 , A61K39/00 , C07K2319/00 , C12N2770/32122
摘要： A method of making a genetically-engineered cell line which is susceptible to infection by foot-and-mouth disease virus and allows the virus to replicate is disclosed. The method involves fusing the DNA encoding ICAM-1 with the DNA encoding an antibody specific for foot-and-mouth disease virus and expressing the resulting chimeric cell surface receptor protein. The chimeric cell surface receptor protein allows foot-and-mouth disease virus to bind, leading to subsequent infection and replication of foot-and-mouth disease virus. A genetically-engineered cell which expresses the chimeric cell surface receptor protein is also claimed.
摘要翻译： 公开了一种使口蹄疫病毒易感染并允许病毒复制的遗传工程细胞系的方法。 该方法包括将编码ICAM-1的DNA与编码针对口蹄疫病毒特异性抗体的DNA融合并表达所得的嵌合细胞表面受体蛋白。 嵌合细胞表面受体蛋白质允许口蹄疫病毒结合，导致口蹄疫病毒的随后的感染和复制。 还要求一种表达嵌合细胞表面受体蛋白质的遗传工程改造的细胞。
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7.发明授权Leader-proteinase deleted foot-and-mouth disease viruses and their use as vaccines 失效引导蛋白酶缺失口蹄疫病毒及其作为疫苗的用途
公开(公告)号：US5824316A
公开(公告)日：1998-10-20
申请号：US653037
申请日：1996-05-24
IPC分类号： A61K39/00 , C07K14/09 , C12N7/04 , A61K39/135
CPC分类号： C07K14/005 , C12N7/00 , A61K39/00 , C12N2770/32122 , C12N2770/32123
摘要： A foot-and-mouth disease virus has been genetically engineered by deleting the nucleic acid sequence encoding the leader (L) proteinase from an infectious cDNA copy of the viral genome and producing an L proteinase-deleted virus. The L proteinase-deleted viruses are able to assemble and grow in cells in culture, but, since they lack L proteinase, they are less toxic to infected cells within the animal, producing an attenuated infection. The recombinant virus can be formulated into an effective vaccine for the prevention of foot-and-mouth disease.
摘要翻译： 通过从病毒基因组的感染性cDNA拷贝中缺失编码前导序列（L）蛋白酶的核酸序列，并产生缺失L蛋白酶的病毒，口蹄疫病毒已被遗传工程化。 L蛋白酶缺失的病毒能够在培养物中的细胞中进行组装和生长，但是由于它们缺乏L蛋白酶，它们对动物内的感染细胞的毒性较小，产生减毒的感染。 重组病毒可配制成用于预防口蹄疫的有效疫苗。
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公开(公告)号：US5612040A
公开(公告)日：1997-03-18
申请号：US418716
申请日：1995-04-07
IPC分类号： A61K39/00 , C07K14/09 , C07K14/705 , A61K39/135 , C07H21/02 , C12N7/04 , C12N7/06
CPC分类号： C07K14/005 , C07K14/70525 , A61K39/00 , C07K2319/00 , C12N2770/32122
摘要： A safe, effective vaccine for the protection of susceptible animals against foot-and-mouth disease has been produced. The vaccine comprises a mutant virus from which the amino acid sequence Gly-Val-Arg-Gly-Asp-Phe (SEQ ID NO: 8) from the G-H loop of VP1 has been deleted and replaced with the amino acid sequence Asn-Pro. The mutant virus retains its antigenicity but is not infectious.
摘要翻译： 已经制备了一种安全有效的疫苗，用于保护易感染动物免受口蹄疫。 疫苗包含来自VP1的G-H环的氨基酸序列Gly-Val-Arg-Gly-Asp-Phe（SEQ ID NO：8）的突变病毒，并且被氨基酸序列Asn-Pro替代。 突变体病毒保留其抗原性，但不具有感染性。
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9.发明授权Immunostimulatory nanoparticles and related compositions, methods and systems 有权免疫刺激纳米颗粒及相关组合物，方法和系统公开(公告)号：US08889623B2
公开(公告)日：2014-11-18
申请号：US12604362
申请日：2009-10-22
CPC分类号： A61K47/48853 , A61K47/646 , A61K47/6921 , Y10S977/799
摘要： Provided herein are immunostimulatory nanolipoprotein particles and related compositions methods and systems.
摘要翻译： 本文提供免疫刺激性纳牛脂蛋白颗粒和相关组合物的方法和系统。
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10.发明授权公开(公告)号：US08883729B2
公开(公告)日：2014-11-11
申请号：US12469533
申请日：2009-05-20
CPC分类号： A61K47/48853 , A61K47/646 , A61K47/6921 , Y10S977/799
摘要： Functionalized nanolipoprotein particle presenting an anchor substrate compound for binding with a corresponding anchor compound presented on a target molecule, and related compositions methods and systems.
摘要翻译： 提供锚定底物化合物的官能化纳牛脂蛋白颗粒与相应的靶分子上呈现的锚化合物结合，以及相关的组合物方法和系统。
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