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公开(公告)号：US09896663B2
公开(公告)日：2018-02-20
申请号：US15067991
申请日：2016-03-11
Applicant: Peter MacCallum Cancer Institute
Inventor： Mark A. Dawson , Chun Yew Fong
CPC classification number: C12N5/0694 , C12N2501/065 , G01N33/5011 , G01N33/5044 , G01N33/5073
Abstract: Bromodomain and extra terminal protein (BET) resistant leukemic cell lines and methods for producing such cell lines are described as are methods for using such cell lines in screening assays to identify therapeutic agents. The cell lines can be generated from haematopoietic stem and progenitor cells (HSPCs) that are clonally enriched by serially exposing c-kit positive cells to a BET inhibitor.
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公开(公告)号：US20170260510A1
公开(公告)日：2017-09-14
申请号：US15067991
申请日：2016-03-11
Applicant: Peter MacCallum Cancer Institute
Inventor： Mark A. Dawson , Chun Yew Fong
CPC classification number: C12N5/0694 , C12N2501/065 , G01N33/5011 , G01N33/5044 , G01N33/5073
Abstract: Bromodomain and extra terminal protein (BET) resistant leukemic cell lines and methods for producing such cell lines are described as are methods for using such cell lines in screening assays to identify therapeutic agents. The cell lines can be generated from haematopoietic stem and progenitor cells (HSPCs) that are clonally enriched by serially exposing c-kit positive cells to a BET inhibitor.
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