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    Preparation of submicroscopic particles, particles thus obtained and pharmaceutical compositions containing them
    1.
    发明授权
    Preparation of submicroscopic particles, particles thus obtained and pharmaceutical compositions containing them 失效
    制备亚显微粒子，由此获得的颗粒和含有它们的药物组合物

    公开(公告)号：US4913908A

    公开(公告)日：1990-04-03

    申请号：US193139

    申请日：1988-05-06

    申请人： Patrick Couvreur ,  Michel Roland ,  Peter Speiser

    发明人： Patrick Couvreur ,  Michel Roland ,  Peter Speiser

    IPC分类号： C08F20/00 ,  A61K9/14 ,  A61K9/50 ,  A61K9/51 ,  A61K9/58 ,  A61K38/00 ,  A61K38/28 ,  A61K39/00 ,  A61K49/00 ,  B01J13/00 ,  B01J13/14 ,  C08F22/32

    CPC分类号： A61K9/5138 ,  A61K9/5161 ,  A61K9/5192 ,  B01J13/14 ,  Y10S514/965 ,  Y10T428/2987

    摘要： Process for the preparation of submicroscopic particles formed of a polymerized alkyl cyanoacrylate and containing a biologically active substance.At least one alkyl cyanoacrylate, in which the term "alkyl" denotes an alkyl radical having 1 to 12 carbon atoms, is added, with stirring, to pure water or to an aqueous solution or aqueous colloidal solution of an acid and/or of another water-soluble substance, and the stirring is continued until substantially all the alkyl cyanoacrylate has been converted to submicroscopic particles formed of polyalkyl cyanoacrylate; a biologically active substance is introduced into the reaction medium before the introduction of the monomer or after formation of the submicroscopic particles.The submicroscopic particles are useful as carriers for substances such as medical substances or products for diagnosis.

    摘要翻译： 用于制备由聚合的氰基丙烯酸烷基酯并含有生物活性物质形成的亚显微粒子的方法。 将至少一种氰基丙烯酸烷基酯（其中术语“烷基”表示具有1至12个碳原子的烷基）在搅拌下加入纯水或酸和/或另一种的水溶液或水性胶体溶液 并继续搅拌，直到基本上将所有的氰基丙烯酸烷基酯转化为由氰基丙烯酸聚烷基酯形成的亚显微粒子; 在引入单体之前或在形成亚显微粒子之后，将生物活性物质引入反应介质中。 亚显微粒子可用作医药物质或诊断产品等物质的载体。

    NANOPARTICLES OF BETA-LACTAM DERIVATIVES
    7.
    发明申请
    NANOPARTICLES OF BETA-LACTAM DERIVATIVES 审中-公开
    BETA-LACTAM衍生物的纳米颗粒

    公开(公告)号：US20110269731A1

    公开(公告)日：2011-11-03

    申请号：US13126756

    申请日：2009-10-28

    申请人： Patrick Couvreur ,  Didier Demaele ,  Fatima Zouhiri

    发明人： Patrick Couvreur ,  Didier Demaele ,  Fatima Zouhiri

    IPC分类号： A61K31/43 ,  C07D499/48 ,  A61P31/04 ,  B82Y5/00 ,  B82Y99/00 ,  B82Y40/00

    CPC分类号： A61K47/54

    摘要： The present invention relates to a complex made up of at least one beta-lactam molecule covalently bonded to at least one hydrocarbon radical including at least 18 carbon atoms and containing at least one unit of 2-methyl-buta-2-ene, to nanoparticles of said complexes, and to a method for preparing same, said complex and/or said nanoparticles optionally being in the form of a lyophilisate. The present invention also relates to a pharmaceutical composition including at least said complex and/or said nanoparticles. The invention finally relates to said complex and/or to said nanoparticles for the treatment and/or prevention of bacterial infections, in particular caused by strains that are sensitive to beta-lactams.

    摘要翻译： 本发明涉及一种由至少一种共价结合至少一个包含至少18个碳原子并含有至少一个2-甲基丁-2-烯单元的烃基的β-内酰胺分子与纳米颗粒组成的复合物 的所述复合物，以及其制备方法，所述复合物和/或所述纳米颗粒任选地为冻干物形式。 本发明还涉及包含至少所述复合物和/或所述纳米颗粒的药物组合物。 本发明最终涉及用于治疗和/或预防细菌感染的所述复合物和/或所述纳米颗粒，特别是由对β-内酰胺类敏感的菌株引起的。

    Copolymer and hemoprotein based novel compounds and uses thereof
    10.
    发明申请
    Copolymer and hemoprotein based novel compounds and uses thereof 审中-公开
    基于共聚物和血液蛋白的新型化合物及其用途

    公开(公告)号：US20060182807A1

    公开(公告)日：2006-08-17

    申请号：US10533084

    申请日：2003-06-10

    申请人： Christine Vauthier ,  Cedric Chauvierre ,  Patrick Couvreur ,  Denis Labarre ,  Liliane Leclerc ,  Michael Marden

    发明人： Christine Vauthier ,  Cedric Chauvierre ,  Patrick Couvreur ,  Denis Labarre ,  Liliane Leclerc ,  Michael Marden

    IPC分类号： A61K9/14 ,  A61K38/42 ,  C07K14/80

    CPC分类号： A61K9/0026 ,  A61K9/5138 ,  A61K9/5161 ,  A61K38/42 ,  A61K47/62 ,  A61K47/6905 ,  A61K47/6935 ,  A61K47/6939

    摘要： The invention relates to novel compounds, characterized in that they comprise a hemoprotein which is associated with a sequenced block copolymer, comprising an hydrophilic segment which is an oligo or polysaccharide linked to at least one hydrophobic segment of formula (1) wherein x represents H or an radical which is alkyl, CN or CONHR, Y represents a COOR′, CONHR″ or C6H5 radical, wherein R, R′ and R″ represent, independently from each other, a hydrogen atom, a C1-C20 linear ou branched alkyl group, a C1-C20 linear or branched alcoxy group, an amino acid radical, a mono- or poly-hydroxyl acid radical or an aryl ou heteroaryl C5-C12 radical, and forms associated with a gas. The invention can be used as blood substitutes and depolluting agents.

    摘要翻译： 本发明涉及新化合物，其特征在于它们包含与序列嵌段共聚物相关的血蛋白，其包含与至少一个式（1）的疏水链连接的寡糖或多糖的亲水链段，其中x表示H或 作为烷基，CN或CONHR的基团，Y表示COOR'，CONHR“或C 6 H 5基团，其中R，R'和R”表示 独立地为氢原子，C 1 -C 20直链支链烷基，C 1 -C 3亚烷基 > 20个直链或支链烷氧基，氨基酸基团，单羟基或多羟基酸基或芳基杂芳基C 5 -C 12烷基， 激进和与气体相关的形式。 本发明可用作血液代用品和去污剂。