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    Preparation of submicroscopic particles, particles thus obtained and pharmaceutical compositions containing them
    1.
    发明授权
    Preparation of submicroscopic particles, particles thus obtained and pharmaceutical compositions containing them 失效
    制备亚显微粒子，由此获得的颗粒和含有它们的药物组合物

    公开(公告)号：US4913908A

    公开(公告)日：1990-04-03

    申请号：US193139

    申请日：1988-05-06

    申请人： Patrick Couvreur ,  Michel Roland ,  Peter Speiser

    发明人： Patrick Couvreur ,  Michel Roland ,  Peter Speiser

    IPC分类号： C08F20/00 ,  A61K9/14 ,  A61K9/50 ,  A61K9/51 ,  A61K9/58 ,  A61K38/00 ,  A61K38/28 ,  A61K39/00 ,  A61K49/00 ,  B01J13/00 ,  B01J13/14 ,  C08F22/32

    CPC分类号： A61K9/5138 ,  A61K9/5161 ,  A61K9/5192 ,  B01J13/14 ,  Y10S514/965 ,  Y10T428/2987

    摘要： Process for the preparation of submicroscopic particles formed of a polymerized alkyl cyanoacrylate and containing a biologically active substance.At least one alkyl cyanoacrylate, in which the term "alkyl" denotes an alkyl radical having 1 to 12 carbon atoms, is added, with stirring, to pure water or to an aqueous solution or aqueous colloidal solution of an acid and/or of another water-soluble substance, and the stirring is continued until substantially all the alkyl cyanoacrylate has been converted to submicroscopic particles formed of polyalkyl cyanoacrylate; a biologically active substance is introduced into the reaction medium before the introduction of the monomer or after formation of the submicroscopic particles.The submicroscopic particles are useful as carriers for substances such as medical substances or products for diagnosis.

    摘要翻译： 用于制备由聚合的氰基丙烯酸烷基酯并含有生物活性物质形成的亚显微粒子的方法。 将至少一种氰基丙烯酸烷基酯（其中术语“烷基”表示具有1至12个碳原子的烷基）在搅拌下加入纯水或酸和/或另一种的水溶液或水性胶体溶液 并继续搅拌，直到基本上将所有的氰基丙烯酸烷基酯转化为由氰基丙烯酸聚烷基酯形成的亚显微粒子; 在引入单体之前或在形成亚显微粒子之后，将生物活性物质引入反应介质中。 亚显微粒子可用作医药物质或诊断产品等物质的载体。

    Sterilization method and apparatus using a gaseous agent
    4.
    发明授权
    Sterilization method and apparatus using a gaseous agent 失效
    灭菌方法和使用气态剂的装置

    公开(公告)号：US4764351A

    公开(公告)日：1988-08-16

    申请号：US675169

    申请日：1984-11-27

    申请人： Pierre Hennebert ,  Jean Gillard ,  Michel Roland

    发明人： Pierre Hennebert ,  Jean Gillard ,  Michel Roland

    IPC分类号： A61L2/20

    CPC分类号： A61L2/204

    摘要： An apparatus for sterilization comprises a treatment chamber (1) with constant temperature control (3, 4, 5) connected to a source of vacuum (6, 7, 8, 9), and to a circuit for admitting a carrier gas comprising a means (10) for sterilizing a gas and a means (14) for heating the gas at constant temperature as well as a steam generator (16) connected to a water supply (19) and to a system (20) for controlling the temperature and/or pressure (20). In addition, a sterilizing gas generator (21) contains a solution of a sterilizing agent (22) and is equipped with means for heating and/or cooling and for temperature control (24, 25, 26, 27). Also, suitable means (33) for circulating the atmosphere in the chamber (1) in contact with the solution (22) are provided.

    摘要翻译： 灭菌装置包括连接到真空源（6,7,8,9）的具有恒定温度控制（3,4,5）的处理室（1）和用于允许载气的回路，所述载气包括装置 （10）和用于加热恒温下的气体的装置（14）以及连接到水源（19）的蒸汽发生器（16）和用于控制温度和/ 或压力（20）。 此外，杀菌气体发生器（21）含有灭菌剂（22）的溶液，并且配备有用于加热和/或冷却和温度控制的装置（24,25,26,27）。 而且，提供了用于使与所述溶液（22）接触的所述室（1）中的气氛循环的适当装置（33）。

    Sterilization method employing a circulating gaseous sterilant
    5.
    发明授权
    Sterilization method employing a circulating gaseous sterilant 失效
    采用循环气体杀菌剂的灭菌方法

    公开(公告)号：US4637916A

    公开(公告)日：1987-01-20

    申请号：US571765

    申请日：1984-01-18

    申请人： Pierre Hennebert ,  Jean Gillard ,  Michel Roland

    发明人： Pierre Hennebert ,  Jean Gillard ,  Michel Roland

    IPC分类号： A01N25/00 ,  A01M17/00 ,  A61L2/20 ,  A01N27/00

    CPC分类号： A61L2/204

    摘要： A sterilization method comprising subjecting a sterilization chamber to an initial vacuum and then introducing steam to increase chamber pressure. The introduction of steam is interrupted and the chamber is brought into communication with a solution in a gaseous sterilant generator. The mixture of gaseous sterilant and chamber atmosphere are continuously circulated whereby equilibrium is established and the material to be sterilized is subject to constant temperature, pressure, sterilant concentration, and relative humidity for a period of time sufficient for sterilization. Also disclosed is an apparatus capable of performing the sterilization method comprising a sterilization chamber in combination with a gaseous sterilant generator. Formaldehyde is the preferred sterilizing agent.

    摘要翻译： 一种消毒方法，包括将消毒室经受初始真空，然后引入蒸汽以增加室压力。 蒸汽的引入被中断，并且室与气态消毒剂发生器中的溶液连通。 气态灭菌剂和室气氛的混合物连续循环，由此建立平衡，待灭菌的材料经受恒温，压力，灭菌剂浓度和相对湿度，持续一段足以消毒的时间。 还公开了一种能够执行消毒方法的装置，其包括与气体杀菌剂发生器组合的灭菌室。 甲醛是优选的灭菌剂。