公开(公告)号：US20230088857A1

公开(公告)日：2023-03-23

申请号：US17989912

申请日：2022-11-18

Applicant: PARKER HANNIFIN CORPORATION

Inventor： Karl G. Schick ,  David Uhen

IPC: G01N21/03 ,  G01N21/05 ,  G01N21/53 ,  G01N21/85 ,  G01N21/51

Abstract: Disposable, pre-sterilized, and pre-calibrated, pre-validated sensor components are provided. The sensor components interact with a sensor system having disposable fluid conduit or bioreactor bag and a reusable sensor assembly. The components can include an optical bench or inset optical component or module designed to be integrated within the disposable fluid conduit or bioreactor bag, which provides an optical light path through the conduit or bag. The sensors systems are designed to store sensor-specific information, such as calibration and production information, in a non-volatile memory chip on the disposable fluid conduit or bag and on the reusable sensor assembly. Methods for calibrating the sensor and for determining a target property of an unknown fluid are also disclosed. The devices, systems and methods relating to the sensor are suitable for and can be outfitted for turbidity sensing.

公开(公告)号：US20170097297A1

公开(公告)日：2017-04-06

申请号：US15383744

申请日：2016-12-19

Applicant: Parker-Hannifin Corporation

Inventor： Karl G. Schick ,  David Uhen

IPC: G01N21/03 ,  G01N21/51

CPC classification number: G01N21/0303 ,  G01J1/1626 ,  G01N21/05 ,  G01N21/51 ,  G01N21/532 ,  G01N21/8507 ,  G01N2021/0307

Abstract: Disposable, pre-sterilized, and pre-calibrated, pre-validated sensor components are provided. The sensor components interact with a sensor system having disposable fluid conduit or bioreactor bag and a reusable sensor assembly. The components can include an optical bench or inset optical component or module designed to be integrated within the disposable fluid conduit or bioreactor bag, which provides an optical light path through the conduit or bag. The sensors systems are designed to store sensor-specific information, such as calibration and production information, in a non-volatile memory chip on the disposable fluid conduit or bag and on the reusable sensor assembly. Methods for calibrating the sensor and for determining a target property of an unknown fluid are also disclosed. The devices, systems and methods relating to the sensor are suitable for and can be outfitted for turbidity sensing.

公开(公告)号：US20140060161A1

公开(公告)日：2014-03-06

申请号：US13964833

申请日：2013-08-12

Applicant: Parker-Hannifin Corporation

Inventor： Karl G. Schick ,  David Uhen

IPC: G01N37/00

CPC classification number: G01N37/00 ,  A61B2560/028 ,  G01F1/00 ,  G01N27/10 ,  G01N27/4163 ,  G06F19/00 ,  G16H10/40

Abstract: Single-use, pre-sterilized, and pre-calibrated, pre-validated sensors are provided. These sensors are designed to store sensor-specific information, such as calibration and production information, in a non-volatile memory chip on the sensor or in a barcode printed on the sensor. These sensors may be utilized with in-line systems, closed fluid circuits, bioprocessing systems, or systems which require an aseptic environment while avoiding or reducing cleaning procedures and quality assurance variances. The sensors exhibit both their primary sensing function such as conductivity, pH level, dissolved oxygen, pressure or temperature, as well as at least one secondary sensing function of risk management or risk mitigation.

Abstract translation: 提供了一次性，预先灭菌和预校准的预验证传感器。 这些传感器被设计为将传感器特定信息（例如校准和生产信息）存储在传感器上的非易失性存储器芯片中或者印在传感器上的条形码中。 这些传感器可以与在线系统，封闭流体回路，生物处理系统或需要无菌环境同时避免或减少清洁程序和质量保证差异的系统一起使用。 传感器表现出其主要感测功能，例如电导率，pH值，溶解氧，压力或温度，以及风险管理或风险缓解的至少一个次要感测功能。

公开(公告)号：US10001454B2

公开(公告)日：2018-06-19

申请号：US14651133

申请日：2014-03-12

Applicant: Parker-Hannifin Corporation

Inventor： Karl G. Schick ,  David Uhen

IPC: G01N27/26 ,  G01N27/30 ,  G01N27/416 ,  F16K3/00 ,  B01L99/00

CPC classification number: G01N27/302 ,  G01N27/4167

Abstract: Presteralized manifolds having disposable multifunctional sensors are provided which are designed for sterile packaging and single-use approaches. These manifolds, which have disposable tubing and flexible-wall containers and are adapted to interact with other equipment which can be operated by a controller and a flow-imparting unit, provide automated and accurate delivery or purification of biotechnology fluid. The disposable sensor monitors pH, oxygen and electrical conductivity, alone or in combination, that interact with the controller or are connected to a separate user interface. Disposable sensor components and re-usable components can be dockable with each other.

公开(公告)号：US20150323486A1

公开(公告)日：2015-11-12

申请号：US14651133

申请日：2014-03-12

Applicant: PARKER-HANNIFIN CORPORATION

Inventor： Karl G. Schick ,  David Uhen

IPC: G01N27/30

CPC classification number: G01N27/302 ,  G01N27/4167

Abstract: Presteralized manifolds having disposable multifunctional sensors are provided which are designed for sterile packaging and single-use approaches. These manifolds, which have disposable tubing and flexible-wall containers and are adapted to interact with other equipment which can be operated by a controller and a flow-imparting unit, provide automated and accurate delivery or purification of biotechnology fluid. The disposable sensor monitors pH, oxygen and electrical conductivity, alone or in combination, that interact with the controller or are connected to a separate user interface. Disposable sensor components and re-usable components can be dockable with each other.

Abstract translation: 提供具有一次性多功能传感器的预精制歧管，其被设计用于无菌包装和一次性使用方法。 这些歧管具有一次性管道和柔性壁容器并且适于与可由控制器和流动赋予单元操作的其他设备相互作用，提供生物技术流体的自动和准确的递送或纯化。 一次性传感器单独或组合地监测与控制器相互作用或连接到单独的用户界面的pH，氧和电导率。 一次性传感器组件和可重复使用的组件可以彼此对接。

公开(公告)号：US20130161245A1

公开(公告)日：2013-06-27

申请号：US13769971

申请日：2013-02-19

Applicant: Parker-Hannifin Corporation

Inventor： Karl G. Schick

IPC: B01D15/10

CPC classification number: B01D61/20 ,  B01D15/10 ,  B01D15/14 ,  B01D15/247 ,  B01D61/18 ,  B01D61/22 ,  B01D2311/06 ,  B01D2313/50 ,  B01D2313/58 ,  G01N27/10 ,  G01N2030/8813 ,  B01D2311/2649

Abstract: Presteralized manifolds are provided which are designed for sterile packaging and single-use approaches. Disposable tubing and flexible-wall containers are assembled via aseptic connectors. These manifolds are adapted to interact with other equipment which can be operated by a controller which provides automated and accurate delivery of biotechnology fluid. The manifold also can be used in conjunction with one or more sensors such as pressure and conductivity sensors that interact with the controller or are connected to a separate user interface. An aseptic environment obtains avoiding or reducing cleaning and quality assurance procedures.

Abstract translation: 提供了预灭菌歧管，其设计用于无菌包装和一次性使用方法。 一次性管道和柔性壁容器通过无菌连接器组装。 这些歧管适于与可由控制器操作的其他设备相互作用，该控制器提供生物技术流体的自动和准确的输送。 歧管还可以与一个或多个传感器结合使用，例如与控制器交互或连接到单独的用户界面的压力和电导率传感器。 无菌环境可以避免或减少清洁和质量保证程序。

公开(公告)号：US11506597B2

公开(公告)日：2022-11-22

申请号：US15383744

申请日：2016-12-19

Applicant: Parker-Hannifin Corporation

Inventor： Karl G. Schick ,  David Uhen

IPC: G01N21/03 ,  G01N21/05 ,  G01N21/53 ,  G01N21/85 ,  G01N21/51 ,  G01J1/16

Abstract: Disposable, pre-sterilized, and pre-calibrated, pre-validated sensor components are provided. The sensor components interact with a sensor system having disposable fluid conduit or bioreactor bag and a reusable sensor assembly. The components can include an optical bench or inset optical component or module designed to be integrated within the disposable fluid conduit or bioreactor bag, which provides an optical light path through the conduit or bag. The sensors systems are designed to store sensor-specific information, such as calibration and production information, in a non-volatile memory chip on the disposable fluid conduit or bag and on the reusable sensor assembly. Methods for calibrating the sensor and for determining a target property of an unknown fluid are also disclosed. The devices, systems and methods relating to the sensor are suitable for and can be outfitted for turbidity sensing.

公开(公告)号：US09700844B2

公开(公告)日：2017-07-11

申请号：US13769971

申请日：2013-02-19

Applicant: Parker-Hannifin Corporation

Inventor： Karl G. Schick

IPC: B01D61/20 ,  B01D61/22 ,  B01D15/10 ,  B01D61/18 ,  B01D15/14 ,  B01D15/24 ,  G01N27/10 ,  G01N30/88

CPC classification number: B01D61/20 ,  B01D15/10 ,  B01D15/14 ,  B01D15/247 ,  B01D61/18 ,  B01D61/22 ,  B01D2311/06 ,  B01D2313/50 ,  B01D2313/58 ,  G01N27/10 ,  G01N2030/8813 ,  B01D2311/2649

Abstract: Presteralized manifolds are provided which are designed for sterile packaging and single-use approaches. Disposable tubing and flexible-wall containers are assembled via aseptic connectors. These manifolds are adapted to interact with other equipment which can be operated by a controller which provides automated and accurate delivery of biotechnology fluid. The manifold also can be used in conjunction with one or more sensors such as pressure and conductivity sensors that interact with the controller or are connected to a separate user interface. An aseptic environment obtains avoiding or reducing cleaning and quality assurance procedures.

公开(公告)号：US09575087B2

公开(公告)日：2017-02-21

申请号：US13964833

申请日：2013-08-12

Applicant: Parker-Hannifin Corporation

Inventor： Karl G. Schick ,  David Uhen

IPC: G01N27/10 ,  G01N37/00 ,  G06F19/00 ,  G01N27/416 ,  G01F1/00

CPC classification number: G01N37/00 ,  A61B2560/028 ,  G01F1/00 ,  G01N27/10 ,  G01N27/4163 ,  G06F19/00 ,  G16H10/40

Abstract: Single-use, pre-sterilized, and pre-calibrated, pre-validated sensors are provided. These sensors are designed to store sensor-specific information, such as calibration and production information, in a non-volatile memory chip on the sensor or in a barcode printed on the sensor. These sensors may be utilized with in-line systems, closed fluid circuits, bioprocessing systems, or systems which require an aseptic environment while avoiding or reducing cleaning procedures and quality assurance variances. The sensors exhibit both their primary sensing function such as conductivity, pH level, dissolved oxygen, pressure or temperature, as well as at least one secondary sensing function of risk management or risk mitigation.

Abstract translation: 提供了一次性，预先灭菌和预校准的预验证传感器。 这些传感器被设计为将传感器特定信息（例如校准和生产信息）存储在传感器上的非易失性存储器芯片中或者印在传感器上的条形码中。 这些传感器可以与在线系统，封闭流体回路，生物处理系统或需要无菌环境同时避免或减少清洁程序和质量保证差异的系统一起使用。 传感器表现出其主要感测功能，例如电导率，pH值，溶解氧，压力或温度，以及风险管理或风险缓解的至少一个次要感测功能。

公开(公告)号：US09568420B2

公开(公告)日：2017-02-14

申请号：US14334025

申请日：2014-07-17

Applicant: Parker-Hannifin Corporation

Inventor： Karl G. Schick ,  David Uhen

IPC: G01N21/00 ,  G01N21/51 ,  G01N21/05 ,  G01N21/53 ,  G01N21/85 ,  G01N21/03 ,  G01J1/16

CPC classification number: G01N21/0303 ,  G01J1/1626 ,  G01N21/05 ,  G01N21/51 ,  G01N21/532 ,  G01N21/8507 ,  G01N2021/0307

Abstract: Disposable, pre-sterilized, and pre-calibrated, pre-validated sensors are provided. The sensor comprises a disposable fluid conduit or bioreactor bag and a reusable sensor assembly. An optical bench or inset optical component or module is integrated within the disposable fluid conduit or bioreactor bag, which provides an optical light path through the conduit or bag. These sensors are designed to store sensor-specific information, such as calibration and production information, in a non-volatile memory chip on the disposable fluid conduit or bag and on the reusable sensor assembly. Methods for calibrating the sensor and for determining a target property of an unknown fluid are also disclosed. The devices, systems and methods relating to the sensor are suitable for and can be outfitted for turbidity sensing.

Abstract translation: 提供了一次性，预消毒和预校准的预验证传感器。 传感器包括一次性流体导管或生物反应器袋和可重复使用的传感器组件。 光学台或插入式光学部件或模块集成在一次性流体导管或生物反应器袋内，其提供通过导管或袋的光学光路。 这些传感器设计用于将传感器特定的信息（例如校准和生产信息）存储在一次性流体导管或袋上以及可重复使用的传感器组件上的非易失性存储器芯片中。 还公开了用于校准传感器和用于确定未知流体的目标特性的方法。 与传感器有关的设备，系统和方法适用于并可用于浊度检测。