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公开(公告)号:US10180439B2
公开(公告)日:2019-01-15
申请号:US15601040
申请日:2017-05-22
Inventor: Satoshi Arimoto
IPC: C07H21/02 , C07H21/04 , G01N33/94 , C12N15/115 , C12Q1/6804
Abstract: The present invention provides a cocaine aptamer represented by the following chemical formula (Cl), R-DNA-L-Fc (Cl) where R is selected from the group consisting of a hydrocarbon group and the derivative thereof; DNA consists of a gene sequence capable of binding to cocaine; L is a linker represented by ((CH2)2—O)n1—PO4—(CH2)n2-L1; L1 is absent or an optional linker; n1 represents a natural number; n2 represents a natural number; and Fc represents a ferrocene group. The cocaine aptamer is capable of detecting cocaine with high sensitivity.
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公开(公告)号:US09863855B2
公开(公告)日:2018-01-09
申请号:US14740141
申请日:2015-06-15
Inventor: Satoshi Arimoto
IPC: G01N1/22 , G01N33/497 , B05B5/025 , B05B5/053 , B05B5/16
CPC classification number: G01N1/2202 , B05B5/0255 , B05B5/0535 , B05B5/16 , G01N1/2273 , G01N33/497 , G01N2001/2244 , G01N2001/2282
Abstract: The present invention provides an electrostatic atomizer comprising: a container having an inlet; an atomization electrode having one end projecting in the container; an opposite electrode provided in the container; a tubular collection electrode provided opposite to the atomization electrode; a mask surrounding an outer periphery of the tubular collection electrode; and a cooling part for cooling the tubular collection electrode. The opposite electrode is provided between the atomization electrode and the tubular collection electrode. The mask is formed of resin. The mask comprises a mask through-hole. The tubular collection electrode is inserted in the mask through-hole. One end of the tubular collection electrode is located in the mask through-hole. The present invention provides a method for efficiently obtaining a liquid sample from a gaseous sample and an electrostatic atomizer suitable for the method.
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公开(公告)号:US12042260B2
公开(公告)日:2024-07-23
申请号:US17316760
申请日:2021-05-11
Inventor: Yumiko Ohno , Kenji Narumi , Tsuguhiro Korenaga , Jin Muraoka , Satoshi Arimoto , Takamasa Ando
CPC classification number: A61B5/0261 , A61B5/0082 , A61B5/4064 , H04N25/76
Abstract: A biometric apparatus includes a light source, an image sensor, a control circuit, and a signal processing circuit. The control circuit causes a light source to repeatedly emit a light pulse radiated onto a target part including a head of a target, causes an image sensor to receive a reflected light pulse which is caused as the light pulse is radiated onto the target part, causes the image sensor to output first image data indicating appearance of a face of the target, and causes the image sensor to output second image data according to distribution of an amount of light of at least one of components of the reflected light pulse. The signal processing circuit generates data indicating a state of the target based on a temporal change in the first image data and a temporal change in the second image data and outputs the data.
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公开(公告)号:US09541518B2
公开(公告)日:2017-01-10
申请号:US14131522
申请日:2012-12-12
Inventor: Yoshihisa Yamashita , Seiichi Nakatani , Tetsuyoshi Ogura , Koichi Hirano , Makoto Takahashi , Satoshi Arimoto
IPC: G01N27/327 , G01N27/30 , H01R43/16
CPC classification number: G01N27/30 , G01N27/3277 , H01R43/16 , Y10T29/49204
Abstract: An electrochemical detector is an electrochemical detector for detecting a substance in a liquid by generating a redox cycle, the electrochemical detector comprising: a first working electrode having a first electrode surface, a second working electrode having a second electrode surface, and a plurality of insulating spacer particles, wherein the first and second electrode surfaces are placed so as to face each other so that an electric field is formed between the first and second electrode surfaces, and the plurality of spacer particles are placed along the first and second electrode surfaces so as to separate the first and second electrode surfaces from each other.
Abstract translation: 电化学检测器是一种用于通过产生氧化还原循环来检测液体中的物质的电化学检测器,该电化学检测器包括:具有第一电极表面的第一工作电极,具有第二电极表面的第二工作电极和多个绝缘 间隔物颗粒,其中第一和第二电极表面被放置成彼此面对,使得在第一和第二电极表面之间形成电场,并且多个间隔物颗粒沿着第一和第二电极表面放置,以便 以将第一和第二电极表面彼此分离。
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公开(公告)号:US11977018B2
公开(公告)日:2024-05-07
申请号:US17491585
申请日:2021-10-01
Inventor: Satoshi Arimoto
IPC: G01N15/1031 , G01N15/1429 , G01N15/1434
CPC classification number: G01N15/1031 , G01N15/1429 , G01N2015/144
Abstract: A target substance detection method includes forming a complex by causing a target substance and a dielectric particle to bind to each other, the dielectric particle being modified with a substance (for example, an antibody) having a property of specifically binding to the target substance; subjecting a bound particle and an unbound particle to dielectrophoresis in a liquid, the bound particle being the dielectric particle constituting the complex, the unbound particle being a dielectric particle not constituting the complex; and detecting the target substance in the complex, based on a difference in motion between the bound particle and the unbound particle caused by the dielectrophoresis.
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公开(公告)号:US10196679B2
公开(公告)日:2019-02-05
申请号:US15602149
申请日:2017-05-23
Inventor: Satoshi Arimoto
IPC: C07H21/02 , C07H21/04 , C12Q1/6825 , C12Q1/6816 , C12Q1/6804 , C12N15/115 , G01N33/94 , C12Q1/68
Abstract: The present invention provides a cocaine aptamer represented by at least one selected from the group consisting of the following chemical formula (CI) and the following chemical formula (CII), 5′-R-DNA-L-Fc-3′ (CI) 5′-Fc-L-DNA-R-3′ (CII) where R is selected from the group consisting of a hydrocarbon group and the derivative thereof; DNA consists of a gene sequence capable of binding to cocaine; L is absent or an optional linker; and Fc represents a ferrocene group. The above-identified cocaine aptamer is used to detect cocaine with high sensitivity.
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公开(公告)号:US12209962B2
公开(公告)日:2025-01-28
申请号:US17488399
申请日:2021-09-29
Inventor: Satoshi Arimoto
Abstract: A target substance detection method includes forming a complex by causing a target substance and a dielectric particle to bind to each other, the dielectric particle being modified with a substance having a property of specifically binding to the target substance; separating the complex and an unbound particle from each other in a liquid by dielectrophoresis, the unbound particle being a dielectric particle not constituting the complex; and detecting the target substance included in the separated complex by using an imaging element.
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公开(公告)号:US10179915B2
公开(公告)日:2019-01-15
申请号:US15601060
申请日:2017-05-22
Inventor: Satoshi Arimoto
IPC: C07H21/02 , C07H21/04 , C12N15/115
Abstract: The present invention provides a cocaine aptamer represented by the following chemical formula (CI), R-DNA-L-Fc (CI) where R represents R1-PO4—(CH2)n1—; R1 is selected from the group consisting of a hydrocarbon group and the derivative thereof; n1 represents a natural number; DNA consists of a gene sequence capable of binding to cocaine; L is a linker represented by -L1-(CH2)n2-L2-; L1 is absent or an optional linker; L2 is absent or an optional linker; n2 represents a natural number; and Fc represents a ferrocene group. The present invention provides a cocaine aptamer capable of detecting cocaine with high sensitivity.
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