公开(公告)号：US20240298913A1

公开(公告)日：2024-09-12

申请号：US18573695

申请日：2022-06-24

Applicant: PERFUSION TECH APS

Inventor： Mads Holst Aagaard Madsen ,  Morten Asp Vonsild Lund ,  Erik Bærentsen

IPC: A61B5/0275 ,  A61B5/00 ,  A61B5/026 ,  G06T7/00 ,  G06V10/25 ,  G06V10/764

CPC classification number: A61B5/0275 ,  A61B5/0071 ,  A61B5/0261 ,  A61B5/489 ,  G06T7/0014 ,  G06V10/25 ,  G06V10/764 ,  G06T2207/10064 ,  G06T2207/20092 ,  G06T2207/30101 ,  G06V2201/03

Abstract: Disclosed are systems and methods for continuously detecting, and optionally classifying, abnormal perfusion patterns in tissue by means of fluorescence imaging. A computer implemented method for detecting (and/or identifying) one or more areas having an abnormal perfusion pattern in tissue of a subject, for example during a medical procedure, includes: continuously acquiring fluorescence images of the tissue, wherein the fluorescence images are associated with a fluorescent output signal correlated with an input signal defined by a series of boluses of at least one fluorescent imaging agent, and wherein the series of boluses is administered with a predefined and/or controlled duration between subsequent boluses, analyzing the fluorescence images, identifying at least one tissue area with normal perfusion, defining a normal perfusion pattern (in an intensity domain and) in a time domain, and detecting, in the fluorescence images, possible tissue areas with abnormal (non-normal) perfusion pattern.