公开(公告)号：US20240298913A1

公开(公告)日：2024-09-12

申请号：US18573695

申请日：2022-06-24

Applicant: PERFUSION TECH APS

Inventor： Mads Holst Aagaard Madsen ,  Morten Asp Vonsild Lund ,  Erik Bærentsen

IPC: A61B5/0275 ,  A61B5/00 ,  A61B5/026 ,  G06T7/00 ,  G06V10/25 ,  G06V10/764

CPC classification number: A61B5/0275 ,  A61B5/0071 ,  A61B5/0261 ,  A61B5/489 ,  G06T7/0014 ,  G06V10/25 ,  G06V10/764 ,  G06T2207/10064 ,  G06T2207/20092 ,  G06T2207/30101 ,  G06V2201/03

Abstract: Disclosed are systems and methods for continuously detecting, and optionally classifying, abnormal perfusion patterns in tissue by means of fluorescence imaging. A computer implemented method for detecting (and/or identifying) one or more areas having an abnormal perfusion pattern in tissue of a subject, for example during a medical procedure, includes: continuously acquiring fluorescence images of the tissue, wherein the fluorescence images are associated with a fluorescent output signal correlated with an input signal defined by a series of boluses of at least one fluorescent imaging agent, and wherein the series of boluses is administered with a predefined and/or controlled duration between subsequent boluses, analyzing the fluorescence images, identifying at least one tissue area with normal perfusion, defining a normal perfusion pattern (in an intensity domain and) in a time domain, and detecting, in the fluorescence images, possible tissue areas with abnormal (non-normal) perfusion pattern.

公开(公告)号：US20210100461A1

公开(公告)日：2021-04-08

申请号：US17127217

申请日：2020-12-18

Applicant: Perfusion Tech APS

Inventor： Morten Toft Lund ,  Mads Holst Aagaard Madsen

IPC: A61B5/0275 ,  A61B5/1455 ,  A61B5/00 ,  A61B5/026 ,  G01N21/64

Abstract: The present disclosure relates to a system and a method for automatically measuring and assessing hemodynamics in tissue of an anatomical structure of a subject. In particular the present disclosure relates to continuously measuring and assessing hemodynamics in medical procedures using fluorescence imaging and wherein the administration of the fluorescent agent is controlled and automated. One aspect relates to a method of automatic perfusion assessment of an anatomical structure of a subject, the method comprising administration into a vein of a bolus corresponding to less than 0.005 mg ICG/kg body weight of a first fluorescence imaging agent. Another aspect relates to a system for automatic perfusion assessment of an anatomical structure during a medical procedure of a subject comprising a controllable injection pump for holding at least one first fluorescence imaging agent, the injection pump being configured for injecting a predefined amount of said first fluorescence imaging agent into the blood of the subject, wherein the system is configured for receiving and analysing a time series of fluorescence images of the tissue of said anatomical structure following the injection of the first fluorescence imaging agent, and determining at least one perfusion parameter of said anatomical structure based on said analysis.

公开(公告)号：US20220192500A1

公开(公告)日：2022-06-23

申请号：US17127385

申请日：2020-12-18

Applicant: Perfusion Tech APS

Inventor： Morten Toft Lund ,  Mads Holst Aagaard Madsen

IPC: A61B5/00 ,  A61M5/00 ,  A61M5/142 ,  A61B5/0275

Abstract: The present disclosure relates to a system and a method for automatically measuring and assessing hemodynamics in tissue of an anatomical structure of a subject. In particular the present disclosure relates to continuously measuring and assessing hemodynamics in medical procedures using fluorescence imaging and wherein the administration of the fluorescent agent is controlled and automated. One aspect relates to a method of automatic perfusion assessment of an anatomical structure of a subject, the method comprising administration into a vein of a bolus corresponding to less than 0.005 mg ICG/kg body weight of a first fluorescence imaging agent. Another aspect relates to a system for automatic perfusion assessment of an anatomical structure during a medical procedure of a subject comprising a controllable injection pump for holding at least one first fluorescence imaging agent, the injection pump being configured for injecting a predefined amount of said first fluorescence imaging agent into the blood of the subject, wherein the system is configured for receiving and analysing a time series of fluorescence images of the tissue of said anatomical structure following the injection of the first fluorescence imaging agent, and determining at least one perfusion parameter of said anatomical structure based on said analysis.

公开(公告)号：US10912471B2

公开(公告)日：2021-02-09

申请号：US16738078

申请日：2020-01-09

Applicant: Perfusion Tech APS

Inventor： Morten Toft Lund ,  Mads Holst Aagaard Madsen

IPC: A61B5/0275 ,  A61B5/00 ,  A61B5/026 ,  A61M5/00 ,  A61K49/00

Abstract: A system and a method for automatically and continuously measuring and assessing hemodynamics uses fluorescence imaging in which the fluorescent agent is controlled and automated. A method of automatic perfusion assessment of an anatomical structure of a subject includes administration into a vein of a bolus corresponding to less than 0.01 mg ICG/kg body weight of a first fluorescence imaging agent. A system for automatic perfusion assessment during a medical procedure includes a controllable injection pump for holding at least one first fluorescence imaging agent, the injection pump being configured for injecting a predefined amount of the first fluorescence imaging agent into the blood. The system is configured for receiving and analysing a time series of fluorescence images and determining at least one perfusion parameter based on the analysis.

公开(公告)号：US11911139B2

公开(公告)日：2024-02-27

申请号：US17127217

申请日：2020-12-18

Applicant: Perfusion Tech APS

Inventor： Morten Toft Lund ,  Mads Holst Aagaard Madsen

IPC: A61B5/0275 ,  A61B5/1455 ,  A61B5/00 ,  A61B5/026 ,  G01N21/64

CPC classification number: A61B5/0275 ,  A61B5/0059 ,  A61B5/0261 ,  A61B5/14551 ,  G01N21/6486

Abstract: The present disclosure relates to a system and a method for automatically measuring and assessing hemodynamics in tissue of an anatomical structure of a subject. In particular the present disclosure relates to continuously measuring and assessing hemodynamics in medical procedures using fluorescence imaging and wherein the administration of the fluorescent agent is controlled and automated. One aspect relates to a method of automatic perfusion assessment of an anatomical structure of a subject, the method comprising administration into a vein of a bolus corresponding to less than 0.005 mg ICG/kg body weight of a first fluorescence imaging agent.

公开(公告)号：US20230035705A1

公开(公告)日：2023-02-02

申请号：US17786427

申请日：2020-12-21

Applicant: Perfusion Tech APS

Inventor： Morten Toft Lund ,  Mads Holst Aagaard Madsen

IPC: A61B5/00

Abstract: A system and a method is disclosed for continuously identifying blood vessels in tissue during fluorescence imaging. Continuously measuring and assessing hemodynamics in tissue in medical procedures using fluorescence imaging may include the administration of the fluorescent agent that is controlled and automated and thereby identifying, mapping and visualizing blood vessels in the tissue. One embodiment relates a computer implemented method for identifying blood vessels in tissue of a subject, e.g. during a medical procedure, the method including the steps of continuously acquiring fluorescence images of the tissue wherein a fluorescent signal is oscillating with a predetermined pattern, and analysing the fluorescence images and the associated oscillating signal thereby continuously identifying blood vessels in the tissue.

公开(公告)号：US20200146564A1

公开(公告)日：2020-05-14

申请号：US16738078

申请日：2020-01-09

Applicant: Perfusion Tech APS

Inventor： Morten Toft Lund ,  Mads Holst Aagaard Madsen

IPC: A61B5/0275 ,  A61B5/00 ,  A61B5/026 ,  A61M5/00 ,  A61K49/00

Abstract: A system and a method for automatically and continuously measuring and assessing hemodynamics uses fluorescence imaging in which the fluorescent agent is controlled and automated. A method of automatic perfusion assessment of an anatomical structure of a subject includes administration into a vein of a bolus corresponding to less than 0.01 mg ICG/kg body weight of a first fluorescence imaging agent. A system for automatic perfusion assessment during a medical procedure includes a controllable injection pump for holding at least one first fluorescence imaging agent, the injection pump being configured for injecting a predefined amount of the first fluorescence imaging agent into the blood. The system is configured for receiving and analysing a time series of fluorescence images and determining at least one perfusion parameter based on the analysis.