公开(公告)号：US20230212535A1

公开(公告)日：2023-07-06

申请号：US18047019

申请日：2022-10-17

Applicant: Oxford Nanopore Technologies PLC

Inventor： Mark Bruce ,  Andrew John Heron ,  Ruth Moysey ,  Szabolcs Soeroes ,  Elizabeth Jayne Wallace ,  James White

IPC: C12N9/14 ,  C12N9/90 ,  C12Q1/6869

CPC classification number: C12N9/14 ,  C12N9/90 ,  C12Q1/6869 ,  C12Q2565/631 ,  C12Y306/04012

Abstract: The invention relates to a new method of characterising a target polynucleotide. The method uses a pore and a Dda helicase. The helicase controls the movement of the target polynucleotide through the pore. The invention also relates to modified Dda helicases which can be used to control the movement of polynucleotides and are particularly useful for sequencing polynucleotides.

公开(公告)号：US11939359B2

公开(公告)日：2024-03-26

申请号：US17384889

申请日：2021-07-26

Applicant: Oxford Nanopore Technologies PLC

Inventor： Lakmal Jayasinghe ,  Mark Bruce ,  Luke McNeill ,  Ramiz Iqbal Nathani ,  Pratik Raj Singh ,  Neil Roger Wood ,  Stephen Robert Young

IPC: A61K35/62 ,  C07K14/435

CPC classification number: C07K14/43536 ,  A61K35/62

Abstract: The invention relates to mutant forms of lysenin. The invention also relates to analyte characterisation using the mutant forms of lysenin.

公开(公告)号：US11845780B2

公开(公告)日：2023-12-19

申请号：US17108536

申请日：2020-12-01

Applicant: Oxford Nanopore Technologies PLC

Inventor： Mark Bruce ,  James Anthony Clarke ,  Andrew John Heron ,  Lakmal Jayasinghe ,  Elizabeth Jayne Wallace

IPC: C07K14/435 ,  C12Q1/68 ,  G01N27/447 ,  C12Q1/6869

CPC classification number: C07K14/43536 ,  G01N27/447 ,  C07K2319/55 ,  C12Q1/6869

Abstract: The invention relates to mutant forms of lysenin. The invention also relates to analyte characterisation using lysenin.

公开(公告)号：US11739377B2

公开(公告)日：2023-08-29

申请号：US17075017

申请日：2020-10-20

Applicant: Oxford Nanopore Technologies PLC

Inventor： Lakmal Nishantha Jayasinghe ,  Elizabeth Jayne Wallace ,  Jonathan Bankes Pugh ,  Richard George Hambley ,  Neil Roger Wood ,  Clive Gavin Brown ,  James White ,  Andrew John Heron ,  Mark Bruce ,  Christopher Peter Youd ,  Rebecca Victoria Bowen

IPC: C07K14/35 ,  C12Q1/68 ,  C12Q1/6869

CPC classification number: C12Q1/6869 ,  C07K14/35 ,  C12Q1/6869 ,  C12Q2563/157 ,  C12Q2565/631

Abstract: The invention relates to improving the movement of a target polynucleotide with respect to a transmembrane pore when the movement is controlled by a polynucleotide binding protein. The invention also relates to improved transmembrane pores and polynucleotide binding proteins.

公开(公告)号：US11965183B2

公开(公告)日：2024-04-23

申请号：US17500831

申请日：2021-10-13

Applicant: Oxford Nanopore Technologies PLC

Inventor： Andrew John Heron ,  Rebecca Victoria Bowen ,  Mark Bruce ,  Lakmal Jayasinghe ,  Joseph Hargreaves Lloyd ,  Szabolcs Soeroes ,  Elizabeth Jayne Wallace ,  Christopher Peter Youd

IPC: C12N9/14 ,  C12Q1/68 ,  C12Q1/6869

CPC classification number: C12N9/14 ,  C12Q1/68 ,  C12Q1/6869 ,  C12Y306/04012 ,  C12Q1/6869 ,  C12Q2521/513 ,  C12Q2565/631

Abstract: The invention relates to modified Dda helicases which can be used to control the movement of polynucleotides and are particularly useful for sequencing polynucleotides.