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1.发明公开公开(公告)号：US20240343704A1
公开(公告)日：2024-10-17
申请号：US18288213
申请日：2022-05-02
发明人： Anh Chau , Methvin Isaac , Babu Joseph , Radek Laufer , Gennady Poda , Michael Prakesch , Pandiaraju Subramanian , David Uehling , Iain Watson , Brian Wilson , Tao Xin
IPC分类号： C07D401/04 , A61K31/4725 , A61K31/496 , A61K31/4995 , A61K31/517 , A61K31/519 , A61K31/53 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/5386 , A61K31/541 , A61K31/5415 , A61K31/55 , A61K31/551 , A61K31/553 , A61K31/695 , C07D401/14 , C07D405/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/10 , C07D491/048 , C07D491/107 , C07D491/113 , C07D495/04 , C07D498/04 , C07D498/10 , C07F7/08
CPC分类号： C07D401/04 , A61K31/4725 , A61K31/496 , A61K31/4995 , A61K31/517 , A61K31/519 , A61K31/53 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/5386 , A61K31/541 , A61K31/5415 , A61K31/55 , A61K31/551 , A61K31/553 , A61K31/695 , C07D401/14 , C07D405/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/10 , C07D491/048 , C07D491/107 , C07D491/113 , C07D495/04 , C07D498/04 , C07D498/10 , C07F7/0836
摘要： The present application relates to halo-substituted heterocyclic compounds of Formula (I): or pharmaceutically acceptable salts, solvates and/or prodrugs thereof, to compositions comprising these compounds or pharmaceutically acceptable salts, solvates and/or prodrugs thereof, and various uses in the treatment of diseases, disorders or conditions that are treatable by inhibiting HPK1, such as cancer.
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2.发明公开公开(公告)号：US20240317723A1
公开(公告)日：2024-09-26
申请号：US18288219
申请日：2022-05-02
发明人： Rima Al-Awar , Methvin Isaac , Babu Joseph , Radek Laufer , Ganna Posternak , Michael Prakesch , David Uehling , Iain Watson , Brian Wilson , Carlos Armando Zepeda-Velazquez , Anh Chau , Tao Xin
IPC分类号： C07D405/14 , A61K31/497 , A61K31/517 , A61K31/5377 , A61P35/00 , C07D401/04 , C07D403/04 , C07D413/14
CPC分类号： C07D405/14 , A61K31/497 , A61K31/517 , A61K31/5377 , A61P35/00 , C07D401/04 , C07D403/04 , C07D413/14
摘要： The present application relates to substituted amino aza-heteroaryl compounds of Formula (I) and substituted aza-heteroaryl compounds of Formula II or pharmaceutically acceptable salts, solvates and/or prodrugs thereof, to compositions comprising these compounds or pharmaceutically acceptable salts, solvates and/or prodrugs thereof, and various uses in the treatment of diseases, disorders or conditions that are treatable by inhibiting HPK1, such as cancer.
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公开(公告)号：US20200331921A1
公开(公告)日：2020-10-22
申请号：US16960924
申请日：2019-02-06
发明人： Rima Al-awar , Methvin Isaac , Anh My Chau , Ahmed Mamai , Lain Watson , Gennady Poda , Pandiaraju Subramanian , Brian Wilson , David Uehling , Michael Prakesch , Babu Joseph , Justin-Alexander Morin
IPC分类号： C07D487/04 , C07D519/00 , C07D471/04
摘要： The present application relates to compounds of Formula I (I) or pharmaceutically acceptable salts, solvates and/or prodrugs thereof, to compositions comprising these compounds or pharmaceutically acceptable salts, solvates and/or prodrugs thereof, and various uses in the treatment of diseases, disorders or conditions that are treatable by inhibiting interactions with BCL6 BTB, such as cancer.
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公开(公告)号：US11518764B2
公开(公告)日：2022-12-06
申请号：US16960924
申请日：2019-02-06
发明人： Rima Al-awar , Methvin Isaac , Anh My Chau , Ahmed Mamai , Iain Watson , Gennady Poda , Pandiaraju Subramanian , Brian Wilson , David Uehling , Michael Prakesch , Babu Joseph , Justin-Alexander Morin
IPC分类号： A61K31/437 , A61K31/519 , C07D471/04 , C07D487/04 , C07D519/00 , A61K45/06
摘要： The present application relates to compounds of Formula I or pharmaceutically acceptable salts, solvates and/or prodrugs thereof, to compositions comprising these compounds or pharmaceutically acceptable salts, solvates and/or prodrugs thereof, and various uses in the treatment of diseases, disorders or conditions that are treatable by inhibiting interactions with BCL6 BTB, such as cancer.
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