公开(公告)号：US20170266276A1

公开(公告)日：2017-09-21

申请号：US15531876

申请日：2015-12-02

Applicant: OncoMed Pharmaceuticals, Inc.

Inventor： Austin L. GURNEY ,  Wan-Ching YEN ,  Timothy Charles HOEY

IPC: A61K39/385 ,  A61K39/395 ,  A61K39/44 ,  A61K39/00

CPC classification number: A61K39/385 ,  A61K31/337 ,  A61K31/357 ,  A61K31/427 ,  A61K31/475 ,  A61K39/0011 ,  A61K39/39558 ,  A61K39/39591 ,  A61K39/44 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/507 ,  A61P35/00 ,  C07K16/18 ,  C07K2317/22 ,  C07K2317/24 ,  C07K2317/30 ,  C07K2317/32 ,  A61K2300/00

Abstract: Described herein are combination therapies for the treatment of cancer and other diseases. In one aspect, the methods described herein for the treatment of cancer and other diseases comprise administering an RSPO-LGR pathway inhibitor in combination with a mitotic inhibitor.

公开(公告)号：US20170198031A1

公开(公告)日：2017-07-13

申请号：US15298527

申请日：2016-10-20

Applicant: OncoMed Pharmaceuticals, Inc.

Inventor： Austin L. GURNEY ,  Timothy Charles HOEY ,  Edward Thein Htun van der HORST ,  Aaron Ken SATO ,  Yuan Ching LIU ,  Maureen Fitch BRUHNS ,  John A. LEWICKI

IPC: C07K16/22 ,  A61K45/06 ,  A61K31/337 ,  A61K39/395

CPC classification number: C07K16/22 ,  A61K31/337 ,  A61K39/3955 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  A61N5/10 ,  C07H21/04 ,  C07K14/435 ,  C07K14/71 ,  C07K16/28 ,  C07K16/30 ,  C07K16/3046 ,  C07K16/462 ,  C07K16/464 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76 ,  C07K2317/92 ,  C12N5/0693 ,  C12N5/12 ,  C12N15/63 ,  C12N15/79 ,  C12N2501/998

Abstract: The present invention relates to Notch-binding agents and Notch antagonists and methods of using the agents and/or antagonists for treating diseases such as cancer. The present invention provides antibodies that specifically bind to a non-ligand binding region of the extracellular domain of one or more human Notch receptor, such as Notch2 and/or Notch3, and inhibit tumor growth. The present invention further provides methods of treating cancer, the methods comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human Notch receptor protein and inhibits tumor growth.

公开(公告)号：US20130243774A1

公开(公告)日：2013-09-19

申请号：US13797374

申请日：2013-03-12

Applicant: ONCOMED PHARMACEUTICALS, INC.

Inventor： Edward Thein Htun van der HORST ,  Austin L. GURNEY ,  Timothy Charles HOEY ,  Maureen Fitch BRUHNS ,  Fumiko Takada AXELROD

IPC: A61K39/395 ,  A61K45/06 ,  C07K16/28

CPC classification number: A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/28 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present invention relates to Notch1 binding agents and methods of using the agents for treating diseases, such as hematologic cancers. The present invention provides antibodies that specifically bind to a non-ligand binding membrane proximal region of the extracellular domain of human Notch1. The present invention further provides methods of using agents that inhibit Notch1 activity for treating cancer. Also described are methods of treating hematologic cancers comprising administering a therapeutically effective amount of a binding agent or antibody of the present invention to a subject having a hematologic cancer such as T-cell lymphoblastic leukemia.

Abstract translation: 本发明涉及Notch1结合剂和使用该药物治疗疾病如血液癌症的方法。 本发明提供特异性结合人Notch1细胞外结构域的非配体结合膜近端区域的抗体。 本发明还提供使用抑制Notch1活性治疗癌症的药剂的方法。 还描述了治疗血液癌症的方法，包括将治疗有效量的本发明的结合剂或抗体给予具有血液学癌症如T细胞淋巴细胞白血病的受试者。

公开(公告)号：US20180244783A1

公开(公告)日：2018-08-30

申请号：US15755142

申请日：2016-08-31

Applicant: OncoMed Pharmaceuticals, Inc.

Inventor： Timothy Charles HOEY ,  Christopher Lamond MURRIEL ,  Jennifer Anne CAIN

IPC: C07K16/28 ,  A61P35/00 ,  A61K38/17 ,  A61K39/395

CPC classification number: C07K16/2863 ,  A61K38/177 ,  A61K38/179 ,  A61K39/39558 ,  A61K2039/507 ,  A61P35/00 ,  C07K16/2818 ,  C07K16/2827 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2319/30 ,  A61K2300/00

Abstract: The present invention provides methods comprising combination therapy for modulating immune responses, for inhibiting tumor growth, and/or for treating cancer. In particular, the present invention provides Wnt pathway inhibitors in combination with immunotherapeutic agents for the treatment of cancer and other diseases.

公开(公告)号：US20130323266A1

公开(公告)日：2013-12-05

申请号：US13895543

申请日：2013-05-16

Applicant: OncoMed Pharmaceuticals, Inc.

Inventor： Timothy Charles HOEY ,  John A. Lewicki ,  Wan-Ching Yen ,  Jakob Dupont

IPC: A61K39/395 ,  A61K45/06

CPC classification number: A61K39/3955 ,  A61K31/7068 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/545 ,  C07K16/28 ,  A61K2300/00

Abstract: The present invention provides methods for treating cancer. More particularly, the invention provides methods for treating cancer comprising administrating doses of a Notch2/3 antibody.

Abstract translation: 本发明提供了治疗癌症的方法。 更具体地说，本发明提供治疗癌症的方法，包括施用Notch2 / 3抗体的剂量。

公开(公告)号：US20180273618A1

公开(公告)日：2018-09-27

申请号：US15889532

申请日：2018-02-06

Applicant: OncoMed Pharmaceuticals, Inc.

Inventor： Christopher Lamond MURRIEL ,  Timothy Charles HOEY ,  Austin L. GURNEY ,  Julie Michelle RODA ,  Minu K. SRIVASTAVA ,  Inkyung PARK ,  Jakob DUPONT

IPC: C07K16/28 ,  A61K31/519 ,  A61K39/395 ,  A61K31/282 ,  A61K39/00

CPC classification number: C07K16/28 ,  A61K31/282 ,  A61K31/519 ,  A61K39/39558 ,  A61K2039/507 ,  A61K2039/572 ,  C07K16/2803 ,  C07K16/2827 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/76 ,  A61K39/395 ,  A61K2300/00

Abstract: The present invention provides methods comprising combination therapy for modulating immune responses, for inhibiting tumor growth, and/or for treating cancer. In particular, the present invention provides Notch pathway inhibitors in combination with immunotherapeutic agents for the treatment of cancer and other diseases.

公开(公告)号：US20160324961A1

公开(公告)日：2016-11-10

申请号：US15097631

申请日：2016-04-13

Applicant: OncoMed Pharmaceuticals, Inc.

Inventor： Robert Joseph STAGG ,  Steven Eugene BENNER ,  John LEWICKI ,  Timothy Charles HOEY

IPC: A61K39/395 ,  A61K31/337 ,  A61K31/7068

CPC classification number: A61K39/3955 ,  A61K31/337 ,  A61K31/7068 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/545 ,  C07K16/22 ,  C07K2317/565

Abstract: The present invention provides methods for treating cancer. More particularly, the invention provides methods for treating cancer comprising administrating doses of a DLL4 antagonist.

Abstract translation: 本发明提供了治疗癌症的方法。 更具体地，本发明提供了治疗癌症的方法，包括施用剂量的DLL4拮抗剂。

公开(公告)号：US20170298143A1

公开(公告)日：2017-10-19

申请号：US15480081

申请日：2017-04-05

Applicant: OncoMed Pharmaceuticals, Inc.

Inventor： Austin L. GURNEY ,  Fumiko Takada AXELROD ,  Timothy Charles HOEY ,  Cecile CHARTIER-COURTAUD

IPC: C07K16/30 ,  A61K39/395 ,  A61K45/06 ,  C07K16/18 ,  C07K16/28 ,  C07K16/46 ,  G01N33/574 ,  A61K39/00

CPC classification number: C07K16/303 ,  A61K39/39533 ,  A61K39/3955 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/18 ,  C07K16/2863 ,  C07K16/3015 ,  C07K16/3023 ,  C07K16/3046 ,  C07K16/3069 ,  C07K16/461 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/30 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/30 ,  G01N33/57415 ,  G01N33/57423 ,  G01N33/57449 ,  G01N2800/52 ,  A61K2300/00

Abstract: The present invention relates to RSPO-binding agents and methods of using the agents for treating diseases such as cancer. The present invention provides antibodies that specifically bind human RSPO proteins and modulate β-catenin activity. The present invention further provides methods of using agents that modulate the activity of RSPO proteins, such as antibodies that specifically bind RSPO1, RSPO2, and/or RSPO3 and inhibit tumor growth. Also described are methods of treating cancer comprising administering a therapeutically effect amount of an agent or antibody of the present invention to a patient having a tumor or cancer.

公开(公告)号：US20160030561A1

公开(公告)日：2016-02-04

申请号：US14776259

申请日：2014-03-13

Applicant: ONCOMED PHARMACEUTICALS, INC.

Inventor： Timothy Charles HOEY ,  Chun ZHANG ,  Ann M. KAPOUN

IPC: A61K39/395 ,  G01N33/574 ,  C12Q1/68 ,  C07K16/28 ,  A61K45/06

CPC classification number: A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/28 ,  C07K2317/76 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/158 ,  G01N33/57438 ,  G01N2333/705 ,  G01N2800/52 ,  A61K2300/00

Abstract: Novel methods of treating pancreatic cancer are provided. In one embodiment, the method comprises determining NOTCH mRNA expression levels in pancreatic cancer cells. In another embodiment, the method further comprises administering to a subject in need thereof a therapeutically effective dose of a NOTCH antagonist.

Abstract translation: 提供了治疗胰腺癌的新方法。 在一个实施方案中，该方法包括确定胰腺癌细胞中的NOTCH mRNA表达水平。 在另一个实施方案中，所述方法还包括向有需要的受试者施用治疗有效剂量的NOTCH拮抗剂。