公开(公告)号：US20170188555A1

公开(公告)日：2017-07-06

申请号：US15348306

申请日：2016-11-10

Applicant: Omeros Corporation

Inventor： George A. Gaitanaris ,  John E. Bergmann ,  Alexander Gragerov ,  John Hohmann ,  Fusheng Li ,  Linda Madisen ,  Kellie L. McIlwain ,  Maria N. Pavlova ,  Demetri Vassilatis ,  Hongkui Zeng

IPC: A01K67/027 ,  A61K49/00 ,  C07K14/72 ,  G01N33/50

CPC classification number: A01K67/0278 ,  A01K2217/00 ,  A01K2217/052 ,  A01K2227/105 ,  A01K2267/03 ,  A61K38/00 ,  A61K49/0008 ,  C07K14/723 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N33/5023 ,  G01N2333/726 ,  G01N2800/04 ,  G01N2800/28 ,  G01N2800/50

Abstract: The present invention provides GPCR polypeptides and polynucleotides, recombinant materials, and transgenic mice, as well as methods for their production. The polypeptides and polynucleotides are useful, for example, in methods of diagnosis and treatment of diseases and disorders. The invention also provides methods for identifying compounds (e.g., agonists or antagonists) using the GPCR polypeptides and polynucleotides of the invention, and for treating conditions associated with GPCR dysfunction with the GPCR polypeptides, polynucleotides, or identified compounds. The invention also provides diagnostic assays for detecting diseases or disorders associated with inappropriate GPCR activity or levels.

公开(公告)号：US10292374B2

公开(公告)日：2019-05-21

申请号：US15348306

申请日：2016-11-10

Applicant: Omeros Corporation

Inventor： George A. Gaitanaris ,  John E. Bergmann ,  Alexander Gragerov ,  John Hohmann ,  Fusheng Li ,  Linda Madisen ,  Kellie L. McIlwain ,  Maria N. Pavlova ,  Demetri Vassilatis ,  Hongkui Zeng

IPC: A01K67/027 ,  C07K14/72 ,  C12Q1/6883 ,  A61K49/00 ,  G01N33/50 ,  A61K38/00

Abstract: The present invention provides GPCR polypeptides and polynucleotides, recombinant materials, and transgenic mice, as well as methods for their production. The polypeptides and polynucleotides are useful, for example, in methods of diagnosis and treatment of diseases and disorders. The invention also provides methods for identifying compounds (e.g., agonists or antagonists) using the GPCR polypeptides and polynucleotides of the invention, and for treating conditions associated with GPCR dysfunction with the GPCR polypeptides, polynucleotides, or identified compounds. The invention also provides diagnostic assays for detecting diseases or disorders associated with inappropriate GPCR activity or levels.

公开(公告)号：US20160282365A1

公开(公告)日：2016-09-29

申请号：US15007805

申请日：2016-01-27

Applicant: Omeros Corporation

Inventor： George A. Gaitanaris ,  John E. Bergmann ,  Alexander Gragerov ,  John Hohmann ,  Fusheng Li ,  Linda Madisen ,  Kellie L. McIlwain ,  Maria N. Pavlova ,  Demetri Vassilatis ,  Hongkui Zeng

IPC: G01N33/74

CPC classification number: G01N33/74 ,  A61K38/00 ,  C07K14/705 ,  C07K14/723 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N2333/726 ,  G01N2500/04 ,  G01N2500/10 ,  Y02A50/463 ,  Y02A50/469 ,  Y02A50/475 ,  Y02A50/48

Abstract: The present invention provides GPCR polypeptides and polynucleotides, recombinant materials, and transgenic mice, as well as methods for their production. The polypeptides and polynucleotides are useful, for example, in methods of diagnosis and treatment of diseases and disorders. The invention also provides methods for identifying compounds (e.g., agonists or antagonists) using the GPCR polypeptides and polynucleotides of the invention, and for treating conditions associated with GPCR dysfunction with the GPCR polypeptides, polynucleotides, or identified compounds. The invention also provides diagnostic assays for detecting diseases or disorders associated with inappropriate GPCR activity or levels.

公开(公告)号：US20160219845A1

公开(公告)日：2016-08-04

申请号：US14633554

申请日：2015-02-27

Applicant: Omeros Corporation

Inventor： George A. Gaitanaris ,  John E. Bergmann ,  Alexander Gragerov ,  John Hohmann ,  Fusheng Li ,  Linda Madisen ,  Kellie L. McIlwain ,  Maria N. Pavlova ,  Demetri Vassilatis ,  Hongkui Zeng

IPC: A01K67/027

CPC classification number: A01K67/0278 ,  A01K2217/00 ,  A01K2217/052 ,  A01K2227/105 ,  A01K2267/03 ,  A61K38/00 ,  A61K49/0008 ,  C07K14/723 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N33/5023 ,  G01N2333/726 ,  G01N2800/04 ,  G01N2800/28 ,  G01N2800/50

Abstract: The present invention provides GPCR polypeptides and polynucleotides, recombinant materials, and transgenic mice, as well as methods for their production. The polypeptides and polynucleotides are useful, for example, in methods of diagnosis and treatment of diseases and disorders. The invention also provides methods for identifying compounds (e.g., agonists or antagonists) using the GPCR polypeptides and polynucleotides of the invention, and for treating conditions associated with GPCR dysfunction with the GPCR polypeptides, polynucleotides, or identified compounds. The invention also provides diagnostic assays for detecting diseases or disorders associated with inappropriate GPCR activity or levels.