公开(公告)号：US20080081990A1

公开(公告)日：2008-04-03

申请号：US11863599

申请日：2007-09-28

申请人： Omer Berenfeld ,  Jerome Kalifa ,  Jose Jalife

发明人： Omer Berenfeld ,  Jerome Kalifa ,  Jose Jalife

IPC分类号： A61B5/055 ,  G06Q50/00

CPC分类号： A61B1/313 ,  A61B1/042 ,  A61B1/043 ,  A61B5/0071 ,  A61B5/0084 ,  G06Q50/22

摘要： The invention relates to a method of high-resolution mapping of a heart, including: providing a heart mapping apparatus; contacting at least a portion of an intact heart tissue with a voltage-sensitive fluoroscopic dye to generate at least a portion of dyed heart tissue; inserting a first end of the heart mapping apparatus into an intact heart; illuminating the portion of dyed heart tissue with a first range of wavelengths of electromagnetic radiation from the first end of the heart mapping apparatus; collecting a second range of wavelengths of electromagnetic radiation from the portion of dyed heart tissue; and transforming the second range of wavelengths of electromagnetic radiation to at least about 100 points of information, wherein said 100 points of information yields a map of at least one anatomical feature and at least one electrical potential.

摘要翻译： 本发明涉及一种心脏高分辨率测绘方法，包括：提供心脏测绘装置; 使完整的心脏组织的至少一部分与电压敏感的荧光染料接触以产生染色的心脏组织的至少一部分; 将心脏测绘装置的第一端插入完整的心脏; 用来自心脏测绘装置的第一端的电磁辐射的第一波长范围照射染色心脏组织的部分; 从染色的心脏组织的部分收集电磁辐射的第二波长范围; 以及将电磁辐射的第二波长范围变换为至少约100个信息点，其中所述100个信息点产生至少一个解剖特征和至少一个电位的图。

公开(公告)号：US20060122526A1

公开(公告)日：2006-06-08

申请号：US11002947

申请日：2004-12-02

申请人： Omer Berenfeld ,  Jose Jalife ,  Ravi Vaidyanathan

发明人： Omer Berenfeld ,  Jose Jalife ,  Ravi Vaidyanathan

IPC分类号： A61B5/04

CPC分类号： A61B5/046 ,  A61B5/7257 ,  Y10S128/92

摘要： A method and computer program product comprising an algorithm adapted to execute a method of identifying the spatial coordinates of a sustaining source of fibrillatory activity in a heart by computing a set of point-dependent dominant frequencies and a set of point-dependent regularity indices for a set of products of point-dependent unipolar discrete power spectra and point-dependent bipolar discrete power spectra, derived by spectral analyses of corresponding unipolar and bipolar cardiac depolarization signals simultaneously acquired from a set of points of the heart. A maximum dominant frequency is selected whose associated coordinates identify the point of the sustaining source of fibrillatory activity. The magnitude of the regularity index is interpreted to verify the identification of the spatial coordinates of the sustaining source of fibrillatory activity. When indicated, surgical intervention is directed to the spatial coordinates of the sustaining source of fibrillatory activity.

公开(公告)号：US07117030B2

公开(公告)日：2006-10-03

申请号：US11002947

申请日：2004-12-02

申请人： Omer Berenfeld ,  Jose Jalife ,  Ravi Vaidyanathan

发明人： Omer Berenfeld ,  Jose Jalife ,  Ravi Vaidyanathan

IPC分类号： A61B5/0402

CPC分类号： A61B5/046 ,  A61B5/7257 ,  Y10S128/92

摘要： A method and computer program product comprising an algorithm adapted to execute a method of identifying the spatial coordinates of a sustaining source of fibrillatory activity in a heart by computing a set of point-dependent dominant frequencies and a set of point-dependent regularity indices for a set of products of point-dependent unipolar discrete power spectra and point-dependent bipolar discrete power spectra, derived by spectral analyses of corresponding unipolar and bipolar cardiac depolarization signals simultaneously acquired from a set of points of the heart. A maximum dominant frequency is selected whose associated coordinates identify the point of the sustaining source of fibrillatory activity. The magnitude of the regularity index is interpreted to verify the identification of the spatial coordinates of the sustaining source of fibrillatory activity. When indicated, surgical intervention is directed to the spatial coordinates of the sustaining source of fibrillatory activity.

摘要翻译： 一种方法和计算机程序产品，其包括适于执行通过计算一组点依赖主导频率和一组点依赖规则性指数来识别心脏中的纤维性活动的维持源的空间坐标的方法的算法 通过从心脏的一组点同时获取的相应的单极性和双极性心脏去极化信号的光谱分析得出的点依赖性单极性离散功率谱和点依赖性双极离散功率谱的集合。 选择最大主频率，其相关坐标确定维持原纤维活动源的点。 解释规律性指数的大小来验证维持原纤维活动源的空间坐标的识别。 当指出时，手术干预是针对维持原纤维活动源的空间坐标。