公开(公告)号：US11840512B2

公开(公告)日：2023-12-12

申请号：US17859675

申请日：2022-07-07

Applicant: OTSUKA PHARMACEUTICAL CO., LTD.

Inventor： Naohiko Kanai ,  Takayuki Yasutomi ,  Ryosuke Hirota

IPC: C07D263/32

CPC classification number: C07D263/32 ,  C07B2200/13

Abstract: Provided is a crystal of a specific oxazole compound that has specific inhibitory activity against PDE4, and that shows excellent stability. Specifically, provided is a crystal of an oxazole compound represented by formula (5)






wherein the crystal has peaks at diffraction angles 2θ(°) of 9.6±0.2, 19.1±0.2, and 21.2±0.2 in an X-ray powder diffraction pattern measured using CuKα characteristic X-rays.

公开(公告)号：US20240076275A1

公开(公告)日：2024-03-07

申请号：US18498894

申请日：2023-10-31

Applicant: Otsuka Pharmaceutical Co., Ltd.

Inventor： Naohiko Kanai ,  Takayuki Yasutomi ,  Ryosuke Hirota

IPC: C07D263/32

CPC classification number: C07D263/32 ,  C07B2200/13

Abstract: Provided is a crystal of a specific oxazole compound that has specific inhibitory activity against PDE4, and that shows excellent stability. Specifically, provided is a crystal of an oxazole compound represented by formula (5)




wherein the crystal has peaks at diffraction angles)2θ(°) of 9.6±0.2, 19.1±0.2, and 21.2±0.2 in an X-ray powder diffraction pattern measured using CuKα characteristic X-rays.

公开(公告)号：US20220411386A1

公开(公告)日：2022-12-29

申请号：US17859675

申请日：2022-07-07

Applicant: OTSUKA PHARMACEUTICAL CO., LTD.

Inventor： Naohiko Kanai ,  Takayuki Yasutomi ,  Ryosuke Hirota

IPC: C07D263/32

Abstract: Provided is a crystal of a specific oxazole compound that has specific inhibitory activity against PDE4, and that shows excellent stability. Specifically, provided is a crystal of an oxazole compound represented by formula (5) wherein the crystal has peaks at diffraction angles 2θ(°) of 9.6±0.2, 19.1±0.2, and 21.2±0.2 in an X-ray powder diffraction pattern measured using CuKα characteristic X-rays.

公开(公告)号：US11414391B2

公开(公告)日：2022-08-16

申请号：US17044892

申请日：2019-04-03

Applicant: OTSUKA PHARMACEUTICAL CO., LTD.

Inventor： Naohiko Kanai ,  Takayuki Yasutomi ,  Ryosuke Hirota

IPC: C07D263/32

Abstract: Provided is a crystal of a specific oxazole compound that has specific inhibitory activity against PDE4, and that shows excellent stability. Specifically, provided is a crystal of an oxazole compound represented by formula (5) wherein the crystal has peaks at diffraction angles 2θ(°) of 9.6±0.2, 19.1±0.2, and 21.2±0.2 in an X-ray powder diffraction pattern measured using CuKα characteristic X-rays.

公开(公告)号：US10588893B2

公开(公告)日：2020-03-17

申请号：US16064618

申请日：2016-12-27

Applicant: OTSUKA PHARMACEUTICAL CO., LTD.

Inventor： Yoshihiro Murakami ,  Hitoshi Matsushita ,  Kengo Matsumoto ,  Minoru Okada ,  Yohei Yuki ,  Noriyuki Koyama ,  Naohiko Kanai

IPC: A61K31/421 ,  A61K9/06 ,  A61K47/44 ,  A61P17/04 ,  C07D263/32

Abstract: An ointment is provided. The ointment stably comprises an oxazole compound that has specific inhibitory activity against PDE4 and that is represented by the following formula (11). The ointment can be efficiently absorbed into the skin.