公开(公告)号：US11840512B2

公开(公告)日：2023-12-12

申请号：US17859675

申请日：2022-07-07

申请人： OTSUKA PHARMACEUTICAL CO., LTD.

发明人： Naohiko Kanai ,  Takayuki Yasutomi ,  Ryosuke Hirota

IPC分类号： C07D263/32

CPC分类号： C07D263/32 ,  C07B2200/13

摘要： Provided is a crystal of a specific oxazole compound that has specific inhibitory activity against PDE4, and that shows excellent stability. Specifically, provided is a crystal of an oxazole compound represented by formula (5)






wherein the crystal has peaks at diffraction angles 2θ(°) of 9.6±0.2, 19.1±0.2, and 21.2±0.2 in an X-ray powder diffraction pattern measured using CuKα characteristic X-rays.

公开(公告)号：US11414391B2

公开(公告)日：2022-08-16

申请号：US17044892

申请日：2019-04-03

申请人： OTSUKA PHARMACEUTICAL CO., LTD.

发明人： Naohiko Kanai ,  Takayuki Yasutomi ,  Ryosuke Hirota

IPC分类号： C07D263/32

摘要： Provided is a crystal of a specific oxazole compound that has specific inhibitory activity against PDE4, and that shows excellent stability. Specifically, provided is a crystal of an oxazole compound represented by formula (5) wherein the crystal has peaks at diffraction angles 2θ(°) of 9.6±0.2, 19.1±0.2, and 21.2±0.2 in an X-ray powder diffraction pattern measured using CuKα characteristic X-rays.

公开(公告)号：US20240076275A1

公开(公告)日：2024-03-07

申请号：US18498894

申请日：2023-10-31

申请人： Otsuka Pharmaceutical Co., Ltd.

发明人： Naohiko Kanai ,  Takayuki Yasutomi ,  Ryosuke Hirota

IPC分类号： C07D263/32

CPC分类号： C07D263/32 ,  C07B2200/13

摘要： Provided is a crystal of a specific oxazole compound that has specific inhibitory activity against PDE4, and that shows excellent stability. Specifically, provided is a crystal of an oxazole compound represented by formula (5)




wherein the crystal has peaks at diffraction angles)2θ(°) of 9.6±0.2, 19.1±0.2, and 21.2±0.2 in an X-ray powder diffraction pattern measured using CuKα characteristic X-rays.

公开(公告)号：US20220411386A1

公开(公告)日：2022-12-29

申请号：US17859675

申请日：2022-07-07

申请人： OTSUKA PHARMACEUTICAL CO., LTD.

发明人： Naohiko Kanai ,  Takayuki Yasutomi ,  Ryosuke Hirota

IPC分类号： C07D263/32

摘要： Provided is a crystal of a specific oxazole compound that has specific inhibitory activity against PDE4, and that shows excellent stability. Specifically, provided is a crystal of an oxazole compound represented by formula (5) wherein the crystal has peaks at diffraction angles 2θ(°) of 9.6±0.2, 19.1±0.2, and 21.2±0.2 in an X-ray powder diffraction pattern measured using CuKα characteristic X-rays.