公开(公告)号：US20240197753A1

公开(公告)日：2024-06-20

申请号：US18283585

申请日：2022-03-25

Applicant: OSAKA UNIVERSITY ,  CUORIPS INC.

Inventor： Yoshiki SAWA ,  Shigeru MIYAGAWA ,  Yoshiki SAKAI ,  Yasuhiro YANAGI

IPC: A61K31/559 ,  A61K9/06 ,  A61K9/16 ,  A61K9/70 ,  A61K47/42 ,  A61P9/04

CPC classification number: A61K31/559 ,  A61K9/06 ,  A61K9/1647 ,  A61K9/7007 ,  A61K47/42 ,  A61P9/04

Abstract: An object is to provide a pharmaceutical composition that improves cardiac function when administered during coronary artery bypass surgery for ischemic cardiomyopathy. A pharmaceutical composition for improving cardiac function comprising: (A) a release formulation comprising at least poly(lactic-co-glycolic acid) (PLGA) and a prostaglandin 12 receptor agonist, the PLGA having an average molecular weight of 10000 to 30000; and (B) a release formulation comprising at least poly(lactic-co-glycolic acid) (PLGA) and a prostaglandin 12 receptor agonist, the PLGA having an average molecular weight of 40000 to 60000.

公开(公告)号：US20230157634A1

公开(公告)日：2023-05-25

申请号：US17920398

申请日：2021-04-22

Applicant: OSAKA UNIVERSITY

Inventor： Hidetsugu ASANOI ,  Yoshiki SAWA ,  Shigeru MIYAGAWA ,  Sunao IKEGAWA

IPC: A61B5/00 ,  A61B5/11

CPC classification number: A61B5/4842 ,  A61B5/7267 ,  A61B5/7275 ,  A61B5/7246 ,  A61B5/1115 ,  A61B5/6892 ,  A61B2562/0247

Abstract: This invention relates to a prediction support system and associated methods for supporting prediction of the severity of a disease. The systems and methods may perform operations that include continuously detecting whether a patient with the disease is in bed, and acquiring, based on the detection result of the detecting, an in-bed pattern indicating, as a time series, whether the patient is in bed. The systems may include a detection device and an acquisition unit.

公开(公告)号：US20220142507A1

公开(公告)日：2022-05-12

申请号：US17585199

申请日：2022-01-26

Applicant: Sumitomo Riko Company Limited ,  Osaka University

Inventor： Wataru TAKAHASHI ,  Masanori YAMAMOTO ,  Atsuki SHIMIZU ,  Mitsuyoshi KONDO ,  Jun Taguchi ,  Hidetsugu ASANOI ,  Yoshiki SAWA ,  Shigeru MIYAGAWA

IPC: A61B5/113 ,  A61B5/00 ,  A61B5/11

Abstract: A heart failure diagnostic device includes a piezoelectric sensor sheet having flexibility and configured to output a detection signal corresponding to an input vibration. A respiratory signal acquisition unit is configured to extract, as a respiratory signal, a signal of a vibration frequency caused by respiration from the detection signal detected by the piezoelectric sensor sheet. A power spectrum calculator is configured to obtain a power spectrum of a respiratory frequency band from the respiratory signal, and a signal corrector is configured to correct the detection signal such that in the power spectrum, a maximum value of a first-order frequency component of a respiratory waveform is not smaller than 1.5 times a maximum value of a second-order frequency component of the respiratory waveform to obtain the respiratory signal.

公开(公告)号：US20190153391A1

公开(公告)日：2019-05-23

申请号：US15511275

申请日：2015-09-14

Applicant: OSAKA UNIVERSITY

Inventor： Yukiko OCHI ,  Kiyotoshi SEKIGUCHI ,  Shigeru MIYAGAWA ,  Yoshiki SAWA ,  Antti Markus SILTANEN

IPC: C12N5/077 ,  C12N5/074 ,  A61K35/34

CPC classification number: C12N5/0657 ,  A61K35/34 ,  C12N5/0696 ,  C12N2506/45 ,  C12N2533/52

Abstract: The present invention provides a method for preparing a clinically applicable, safe and less damaged cardiomyocyte population through a brief and simple procedure from a cell population obtained by induced differentiation of pluripotent stem cells into cardiomyocytes. The present invention relates to a method for preparing a cardiomyocyte population, the method comprising the steps of: (1) inducing pluripotent stem cells to differentiate into cardiomyocytes, (2) bringing a cell population obtained by the induced differentiation into contact with a laminin selected from the group consisting of laminin α2β1γ1, laminin α2β2γ1, laminin α1β1γ1 and laminin α1β2γ1, or a fragment thereof having integrin binding activity, and (3) retrieving cells adherent to the laminin or the laminin fragment.

公开(公告)号：US20170304504A1

公开(公告)日：2017-10-26

申请号：US15647742

申请日：2017-07-12

Applicant: TERUMO KABUSHIKI KAISHA ,  OSAKA UNIVERSITY

Inventor： Fumiya OOHASHI ,  Ryouhei TAKEUCHI ,  Tadashi SAMESHIMA ,  Shigeru MIYAGAWA ,  Yoshiki SAWA ,  Atsuhiro SAITO

IPC: A61L27/58 ,  A61L27/22 ,  A61L27/38 ,  A61L27/52

CPC classification number: A61L27/58 ,  A61L27/225 ,  A61L27/38 ,  A61L27/52 ,  A61L2430/20

Abstract: A method for treating a disease associated with tissue abnormality in a subject. The method includes administering an amount of a pharmaceutical composition to a subject in need of treating a disease associated with tissue abnormality, the pharmaceutical composition comprising a laminate comprising a fibrin gel and a cell culture. The laminate is produced by a method, which includes forming a fibrin gel layer on an upper surface of the cell culture by a reaction between fibrinogen and thrombin, wherein: the cell culture is prepared on a culture dish and the laminate of the fibrin gel and the cell culture are transferred onto a subject's heart. The laminate further includes a reinforcing portion made of a fibrin gel, the reinforcing portion formed by laminating the fibrin gel on the fibrin gel layer of the laminate of the cell culture and the fibrin gel.

公开(公告)号：US20240316115A1

公开(公告)日：2024-09-26

申请号：US18579093

申请日：2022-07-14

Applicant: Astellas Pharma Inc. ,  OSAKA UNIVERSITY

Inventor： Kenichiro SHIMATANI ,  Hiromu SATO ,  Masao SASAI ,  Yoshiki SAWA ,  Atsuhiro SAITO ,  Shigeru MIYAGAWA

IPC: A61K35/44 ,  C12N5/071

CPC classification number: A61K35/44 ,  C12N5/069 ,  C12N2500/32 ,  C12N2500/90 ,  C12N2501/115 ,  C12N2501/135 ,  C12N2506/02 ,  C12N2509/00 ,  C12N2513/00 ,  C12N2533/52 ,  C12N2533/54

Abstract: An object of the present invention is to provide a pericyte-like cell having high angiogenic potential with a higher cell proliferation ability than a primary pericyte available in the past and high VEGF expression, and a method for producing the same. Provided are a method for producing a VEGF-highly expressing pericyte-like cell, the method including selecting a CD56(−) pericyte-like cell from a population including a pericyte-like cell obtained by inducing differentiation of a pluripotent stem cell; and a VEGF-highly expressing pericyte-like cell produced by the production method.

公开(公告)号：US20220249613A1

公开(公告)日：2022-08-11

申请号：US17734550

申请日：2022-05-02

Applicant: OSAKA UNIVERSITY ,  TERUMO KABUSHIKI KAISHA

Inventor： Yoshiki SAWA ,  Shigeru MIYAGAWA ,  Keisuke MIYAKE ,  Kenji OYAMA

IPC: A61K38/18 ,  C12N5/077 ,  A61K35/34 ,  A61K38/20 ,  A61K38/19 ,  A61K9/00 ,  A61P9/10

Abstract: Cell cultures for treating peripheral arterial disease, methods for producing the cell cultures and methods for treating peripheral arterial disease using the cell cultures are provided. The cell cultures may be 100 to 500 μm in size and may possess an extracellular matrix on an outer surface of the cell culture, and the like are provided.

公开(公告)号：US20210187031A1

公开(公告)日：2021-06-24

申请号：US16071123

申请日：2017-01-18

Applicant: OSAKA UNIVERSITY

Inventor： Daisuke KAJITA ,  Satsuki FUKUSHIMA ,  Shigeru MIYAGAWA ,  Yoshiki SAWA

IPC: A61K35/28 ,  A61K35/35 ,  A61K35/545 ,  A61K35/51

Abstract: It has been found that a cell cluster obtained by causing just isolated cells to adhere to each other secretes adiponectin after transplantation to the heart, and thereby has an excellent therapeutic effect on heart disease.

公开(公告)号：US20210009934A1

公开(公告)日：2021-01-14

申请号：US17042301

申请日：2019-03-12

Applicant: DAI NIPPON PRINTING CO., LTD. ,  OSAKA UNIVERSITY ,  TERUMO KABUSHIKI KAISHA

Inventor： Taro NAGAI ,  Yoshiki SAWA ,  Shigeru MIYAGAWA ,  Kenji OYAMA

IPC: C12M1/00 ,  C12M1/02 ,  C12M1/34 ,  C12M3/06 ,  C12M3/00 ,  C12M1/38 ,  C12M1/22 ,  C12M1/36

Abstract: When detachment of a cell sheet from a culture dish has started at an unintended timing, immediately detach the cell sheet from the culture dish while preventing generation of wrinkles and the like in the cell sheet. A cell culture device captures an image of cells in the culture dish, and controls a cooling mechanism and a shaking mechanism based on the image so as to shake the cells while cooling them.

公开(公告)号：US20240335480A1

公开(公告)日：2024-10-10

申请号：US18579100

申请日：2022-07-14

Applicant: Astellas Pharma Inc. ,  OSAKA UNIVERSITY ,  National Center for Child Health and Development

Inventor： Kenichiro SHIMATANI ,  Hiromu SATO ,  Masao SASAI ,  Yoshiki SAWA ,  Atsuhiro SAITO ,  Shigeru MIYAGAWA

IPC: A61K35/545 ,  A61K35/44 ,  C12N5/071

CPC classification number: A61K35/545 ,  A61K35/44 ,  C12N5/069 ,  C12N2506/02 ,  C12N2513/00

Abstract: An object of the present invention is to provide a pericyte-like cell having high angiogenic potential with a higher cell proliferation ability than a primary pericyte available in the past and high VEGF expression, and a method for producing the same. Provided are a method for producing a VEGF-highly expressing pericyte-like cell, the method including selecting a CD56(−) pericyte-like cell from a population including a pericyte-like cell obtained by inducing differentiation of a pluripotent stem cell; and a VEGF-highly expressing pericyte-like cell produced by the production method.