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公开(公告)号：US20170304504A1
公开(公告)日：2017-10-26
申请号：US15647742
申请日：2017-07-12
发明人： Fumiya OOHASHI , Ryouhei TAKEUCHI , Tadashi SAMESHIMA , Shigeru MIYAGAWA , Yoshiki SAWA , Atsuhiro SAITO
CPC分类号： A61L27/58 , A61L27/225 , A61L27/38 , A61L27/52 , A61L2430/20
摘要： A method for treating a disease associated with tissue abnormality in a subject. The method includes administering an amount of a pharmaceutical composition to a subject in need of treating a disease associated with tissue abnormality, the pharmaceutical composition comprising a laminate comprising a fibrin gel and a cell culture. The laminate is produced by a method, which includes forming a fibrin gel layer on an upper surface of the cell culture by a reaction between fibrinogen and thrombin, wherein: the cell culture is prepared on a culture dish and the laminate of the fibrin gel and the cell culture are transferred onto a subject's heart. The laminate further includes a reinforcing portion made of a fibrin gel, the reinforcing portion formed by laminating the fibrin gel on the fibrin gel layer of the laminate of the cell culture and the fibrin gel.
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2.发明申请METHOD FOR PRODUCING LAMINATE OF SHEET-SHAPED CELL CULTURE AND FIBRIN GEL 有权用于生产片状细胞培养物和纤维蛋白凝胶层压体的方法公开(公告)号：US20160058908A1
公开(公告)日：2016-03-03
申请号：US14844259
申请日：2015-09-03
发明人： Fumiya OOHASHI , Ryouhei TAKEUCHI , Tadashi SAMESHIMA , Shigeru MIYAGAWA , Yoshiki SAWA , Mitsuhiro SAITO
CPC分类号： A61L27/58 , A61L27/225 , A61L27/38 , A61L27/52 , A61L2430/20
摘要： A laminate of a sheet-shaped cell culture is disclosed, which has excellent operability and is suitable for implantation. A method is disclosed for producing a laminate of a fibrin gel and a sheet-shaped cell culture, including a step of dripping a liquid containing fibrinogen onto an upper surface of a sheet-shaped cell culture, a step of spraying a liquid containing thrombin onto the surface, and a step of forming a fibrin gel layer on the surface by a reaction between fibrinogen and thrombin; and a laminate of a fibrin gel and a sheet-shaped cell culture produced by the method are disclosed.
摘要翻译： 公开了一种片状细胞培养物的层压体，其具有优异的可操作性并且适于植入。 公开了用于制造纤维蛋白凝胶和片状细胞培养物的层压体的方法，包括将含有纤维蛋白原的液体滴落到片状细胞培养物的上表面的步骤，将含有凝血酶的液体喷雾到 表面和通过纤维蛋白原和凝血酶之间的反应在表面上形成纤维蛋白凝胶层的步骤; 并且公开了通过该方法制备的纤维蛋白凝胶和片状细胞培养物的层压体。
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3.发明申请公开(公告)号：US20150380012A1
公开(公告)日：2015-12-31
申请号：US14667152
申请日：2015-03-24
摘要： A speech rehabilitation assistance apparatus is disclosed, which can execute effective speech rehabilitation of, for example, a dysarthric speaker. The speech rehabilitation assistance apparatus can include a specification section specifying a target phoneme type and specifying at least one of a word head, a word middle, and a word end as a position of the specified phoneme type, a presentation section presenting a word selected from words having the specified phoneme type in the specified position, a voice recognition section recognizing a voice uttered when a trainee reads out the presented word, and a provision section providing an evaluation value concerning the voice uttered by the trainee based on history of a recognition result by the voice recognition section.
摘要翻译： 公开了一种语音康复辅助装置，其可以执行例如语音扬声器的有效语音康复。 语音康复辅助装置可以包括指定目标音素类型的指定部分，并且将字头，字中，和字结尾中的至少一个指定为指定音素类型的位置，呈现部分， 在指定位置具有指定音素类型的词语，当学员读出所提供的单词时，识别语音发出的语音识别部分;以及提供部分，其基于识别结果的历史提供由受训者发出的语音的评估值 由语音识别部分。
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公开(公告)号：US20210307890A1
公开(公告)日：2021-10-07
申请号：US17351295
申请日：2021-06-18
IPC分类号： A61F2/00
摘要： A device for efficiently attaching a sheet-shaped object to a target site includes a support body for supporting a sheet-shaped object, and a protective member having a low coefficient of friction for protecting one surface of the support, in which the support body supporting the sheet-shaped object is rolled while being protected by the protective member and can be inserted into a tubular body.
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公开(公告)号：US20200148747A1
公开(公告)日：2020-05-14
申请号：US16747948
申请日：2020-01-21
摘要： An object of the present invention is to provide a cell sheet embedding agent, which makes it possible to stably transport a cell sheet at the time of transport at a low temperature and to collect the cell sheet from the cell sheet embedding agent in a simple manner after being transported, a cell sheet-containing composition, and a kit. According to the present invention, there is provided a cell sheet embedding agent containing a polypeptide represented by the following Formula 1, in which in a case where a molecular weight distribution of the polypeptide is measured, a peak area of a maximum molecular weight is equal to or greater than 80% of the total peak area of all molecular weights. A-[(Gly-X—Y)n]m—B Formula 1: In the formula, X and Y each independently represent an amino acid, m is an integer of 2 to 10, n is an integer of 3 to 100, and A and B each represent any amino acid or any amino acid sequence.
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公开(公告)号：US20190010214A1
公开(公告)日：2019-01-10
申请号：US16139620
申请日：2018-09-24
摘要： An object of the present invention is to provide a cell sheet embedding agent, which makes it possible to stably transport a cell sheet at the time of transport at a low temperature and to collect the cell sheet from the cell sheet embedding agent in a simple manner after being transported, a cell sheet-containing composition, and a kit. According to the present invention, there is provided a cell sheet embedding agent containing a polypeptide represented by the following Formula 1, in which in a case where a molecular weight distribution of the polypeptide is measured, a peak area of a maximum molecular weight is equal to or greater than 80% of the total peak area of all molecular weights. A-[(Gly-X—Y)n]m—B Formula 1: In the formula, X and Y each independently represent an amino acid, m is an integer of 2 to 10, n is an integer of 3 to 100, and A and B each represent any amino acid or any amino acid sequence.
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7.发明申请公开(公告)号：US20190008791A1
公开(公告)日：2019-01-10
申请号：US16139814
申请日：2018-09-24
摘要： An object of the present invention is to provide a laminate containing a cell sheet which has hardness and is easy to handle at the time of transplantation or transport, an agent for treating cardiac diseases using the laminate, and a film for being laminated on a cell sheet. According to the present invention there are provided a laminate including a biocompatible polymer film having a density of 500 μg/cm2 to 10 mg/cm2 and a cell sheet disposed on at least one surface of the biocompatible polymer film, an agent for treating cardiac diseases using the laminate, and a film for being laminated on a cell sheet.
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公开(公告)号：US20150371630A1
公开(公告)日：2015-12-24
申请号：US14732263
申请日：2013-10-23
发明人： Miyuki KOYAMA , Tadashi SAMESHIMA , Toshihide TANAKA , Mayumi ITO , Kazuyoshi WARITA , Masakazu ISHIDA
摘要： An information processing apparatus and a method for performing speech training in speech rehabilitation are disclosed. A report about content to be uttered in an utterance training is made to a trainee of the utterance training and the volume of a voice uttered by the trainee in response to the report is obtained. Then, the result of comparison between the obtained volume and a volume predetermined as a target volume is reported.
摘要翻译： 公开了一种在语音康复中执行语音训练的信息处理装置和方法。 对讲话训练的实习生进行了讲话训练内容的报告，得知受训者响应报告发出的声音数量。 然后，报告所获得的体积与作为目标体积预定的体积之间的比较结果。
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公开(公告)号：US20150111183A1
公开(公告)日：2015-04-23
申请号：US14583268
申请日：2014-12-26
摘要： An information processing apparatus is disclosed having a storage unit storing a plurality of training text items each including a word, a word string, or a sentence. The information processing apparatus presents a training text item among the plurality of training text items stored in the storage unit as voice output or character string display and calculates the speaking speed based on a voice signal that is input after presenting the training text item. The information processing apparatus compares the calculated speaking speed with a preset target speaking speed and reports the comparison result.
摘要翻译： 公开了一种信息处理装置，其具有存储单元，字串或句子的多个训练文本项目的存储单元。 信息处理装置将存储在存储单元中的多个训练文本项目中的训练文本项目呈现为语音输出或字符串显示，并且基于在呈现训练文本项目之后输入的语音信号来计算讲话速度。 信息处理装置将计算的说话速度与预设的目标讲话速度进行比较并报告比较结果。
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