公开(公告)号：US20210369731A1

公开(公告)日：2021-12-02

申请号：US17282277

申请日：2019-10-09

申请人： The Regents of the University of California ,  Novartis AG

发明人： Jessica Spradlin ,  Carl C. Ward ,  Daniel K. Nomura ,  Markus Schirle ,  John A. Tallarico ,  Jeffrey McKenna ,  Thomas John Maimone ,  Xirui Hu

IPC分类号： A61K31/551 ,  A61K31/4535 ,  A61K31/365 ,  A61K47/55 ,  A61P35/00

摘要： Disclosed herein, inter alia, are compositions and methods for targeting E3 ligases. In an aspect is a targeted protein degrader including 1) a targeted protein binder and 2) an E3 Ubiquitin ligase binder, wherein the E3 Ubiquitin ligase is human RNF4 or human RNF114. In an aspect is provided a pharmaceutical composition including a compound as described herein, including embodiments, and a pharmaceutically acceptable excipient.

公开(公告)号：US20240252655A1

公开(公告)日：2024-08-01

申请号：US18288550

申请日：2022-04-29

申请人： Novartis AG ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： Lydia Boike ,  Dustin Leard Dovala ,  Nathaniel James Henning ,  Matthew James Hesse ,  Gang Liu ,  Jeffrey M. McKenna ,  Daniel K. Nomura ,  Markus Eberhard Schirle ,  Jessica Nichole Spradlin ,  John A. Tallarico ,  Carl C. Ward ,  Melissa Pighetti

IPC分类号： A61K47/55 ,  C07D241/08 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D487/04

CPC分类号： A61K47/55 ,  C07D241/08 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D487/04

摘要： Described herein are bifunctional compounds, as well as pharmaceutically acceptable salts, hydrates, solvates, prodrugs, stereoisomers, or tautomers thereof, that function to recruit certain deubiquitinases to a target protein for modulation (e.g., stabilization) of the target protein, as well as methods of use thereof.

公开(公告)号：US20200062696A1

公开(公告)日：2020-02-27

申请号：US16482947

申请日：2018-02-02

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： Daniel K. Nomura ,  James A. Olzmann ,  Leslie A. Bateman ,  Truc B. Nguyen ,  David K. Miyamoto ,  Tucker R. Huffman ,  Allison M. Roberts

IPC分类号： C07C233/27 ,  A61P35/00 ,  C07D295/033 ,  C07C233/09 ,  C07D295/104

摘要： Disclosed herein, inter alia, are compositions and methods useful for inhibiting reticulon 4 (RTN4).

公开(公告)号：US20190290778A1

公开(公告)日：2019-09-26

申请号：US16362573

申请日：2019-03-22

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  FRONTIER MEDICINES CORPORATION

发明人： Daniel K. Nomura ,  Roberto Zoncu ,  Carl Ward ,  Sin Ki Fung ,  Chris Kumar Varma ,  Benjamin Fontaine

IPC分类号： A61K47/68 ,  C07K16/28 ,  A61P35/00 ,  A61P25/28 ,  A61P25/14 ,  A61P37/06 ,  A61P3/10

摘要： Provided herein, inter alia, are methods and compounds for targeted autophagy.

公开(公告)号：US20240319200A1

公开(公告)日：2024-09-26

申请号：US18736528

申请日：2024-06-07

申请人： The Regents of the University of California

发明人： Daniel K. Nomura ,  Qian Shao

IPC分类号： G01N33/58 ,  A61K31/407 ,  A61K31/4439 ,  C07D487/10

CPC分类号： G01N33/582 ,  A61K31/407 ,  A61K31/4439 ,  C07D487/10 ,  G01N2500/02

摘要： A novel drug discovery platform identifies compounds for therapeutically targeting 14-3-3 proteins and sequestering and inhibiting the activities of various disease-relevant proteins. Therapeutic compositions comprise a scaffold for therapeutically targeting 14-3-3 proteins and sequestering and inhibiting the activities of various disease-relevant proteins.

公开(公告)号：US20240173428A1

公开(公告)日：2024-05-30

申请号：US18302738

申请日：2023-04-18

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  FRONTIER MEDICINES CORPORATION

发明人： Daniel K. Nomura ,  Roberto Zoncu ,  Carl Ward ,  Sin Ki Fung ,  Chris Kumar Varma ,  Benjamin Fontaine

IPC分类号： A61K47/68 ,  A61P3/10 ,  A61P25/14 ,  A61P25/28 ,  A61P35/00 ,  A61P37/06 ,  C07D495/04 ,  C07K16/28

CPC分类号： A61K47/6889 ,  A61K47/6803 ,  A61P3/10 ,  A61P25/14 ,  A61P25/28 ,  A61P35/00 ,  A61P37/06 ,  C07D495/04 ,  C07K16/28 ,  A61K45/06

摘要： Provided herein, inter alia, are methods and compounds for targeted autophagy.

公开(公告)号：US20230148299A1

公开(公告)日：2023-05-11

申请号：US17802476

申请日：2021-03-08

申请人： The Regents Of The University Of California

发明人： Michael Rape ,  Daniel K. Nomura ,  Nathaniel Henning ,  Andrew Manford

IPC分类号： C07D495/14

CPC分类号： C07D495/14

摘要： Disclosed herein, inter alia, are compounds for binding FEMIB protein and uses thereof. In an aspect, provided input pulldown herein is a pharmaceutical composition including a compound as described herein and a pharmaceutically acceptable excipient.

公开(公告)号：US11666661B2

公开(公告)日：2023-06-06

申请号：US16362573

申请日：2019-03-22

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  FRONTIER MEDICINES CORPORATION

发明人： Daniel K. Nomura ,  Roberto Zoncu ,  Carl Ward ,  Sin Ki Fung ,  Chris Kumar Varma ,  Benjamin Fontaine

IPC分类号： A61K47/68 ,  C07K16/28 ,  A61K45/06 ,  A61P35/00 ,  A61P25/14 ,  A61P37/06 ,  A61P3/10 ,  A61P25/28 ,  C07D495/04 ,  C07D417/12

CPC分类号： A61K47/6889 ,  A61K47/6803 ,  A61P3/10 ,  A61P25/14 ,  A61P25/28 ,  A61P35/00 ,  A61P37/06 ,  C07D495/04 ,  C07K16/28 ,  A61K45/06 ,  C07D417/12

摘要： Provided herein, inter alia, are methods and compounds for targeted autophagy.

公开(公告)号：US10807951B2

公开(公告)日：2020-10-20

申请号：US16159380

申请日：2018-10-12

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： Daniel K. Nomura ,  Roberto Zoncu ,  Allison M. Roberts ,  Kelvin F. Cho ,  Yik Sham Clive Chung ,  Hijai Shin ,  Benjamin Croze

IPC分类号： C07D209/12 ,  C07D209/08 ,  A61K31/00 ,  A61P25/28 ,  A61P3/10 ,  A61P25/16 ,  A61P35/00 ,  A61K47/64

摘要： Provided herein, inter alia, are methods and compounds for inhibiting mTORC1 and for treating diseases associated with mTORC1 activity.

公开(公告)号：US20200054651A1

公开(公告)日：2020-02-20

申请号：US16482952

申请日：2018-02-02

申请人： The Regents of the University of California

发明人： Daniel K. Nomura ,  Elizabeth A. Moore ,  Carl C. Ward ,  Leslie A. Bateman ,  Tucker R. Huffman ,  David K. Miyamoto ,  Jessica Spradlin

IPC分类号： A61K31/585 ,  A61K31/357 ,  A61K31/404 ,  A61K31/167 ,  A61K31/245 ,  A61K31/341 ,  A61K31/165 ,  A61K31/36 ,  A61K31/495 ,  A61K31/40 ,  A61K31/5375 ,  A61K31/445 ,  A61K31/16 ,  A61P35/00 ,  C12N9/16

摘要： Disclosed herein, inter alia, are compositions and methods useful for modulating PPP2R1 A and for the treatment of cancer.