公开(公告)号：US20240252655A1

公开(公告)日：2024-08-01

申请号：US18288550

申请日：2022-04-29

申请人： Novartis AG ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： Lydia Boike ,  Dustin Leard Dovala ,  Nathaniel James Henning ,  Matthew James Hesse ,  Gang Liu ,  Jeffrey M. McKenna ,  Daniel K. Nomura ,  Markus Eberhard Schirle ,  Jessica Nichole Spradlin ,  John A. Tallarico ,  Carl C. Ward ,  Melissa Pighetti

IPC分类号： A61K47/55 ,  C07D241/08 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D487/04

CPC分类号： A61K47/55 ,  C07D241/08 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D487/04

摘要： Described herein are bifunctional compounds, as well as pharmaceutically acceptable salts, hydrates, solvates, prodrugs, stereoisomers, or tautomers thereof, that function to recruit certain deubiquitinases to a target protein for modulation (e.g., stabilization) of the target protein, as well as methods of use thereof.

公开(公告)号：US12129246B1

公开(公告)日：2024-10-29

申请号：US18589841

申请日：2024-02-28

申请人： Novartis AG

发明人： Daniela Angst ,  Philippe Bolduc ,  Matthew William Carson ,  Atwood Kim Cheung ,  Véronique Darsigny ,  Xiang Gao ,  Viktor Hornak ,  Keith Jendza ,  Rajesh Karki ,  Ajay Kumar Lal ,  Gang Liu ,  Justin Yik Ching Mao ,  Jeffrey M. McKenna ,  Erik Meredith ,  Muneto Mogi ,  Vivek Rauniyar ,  Liansheng Su ,  Ritesh Tichkule ,  Shuangxi Wang ,  Chun Zhang ,  Liang Zhao ,  Rui Zheng

IPC分类号： C07D403/14 ,  A61K31/517 ,  A61K31/55 ,  A61K45/06 ,  C07D239/95 ,  C07D401/12 ,  C07D401/14

CPC分类号： C07D403/14 ,  A61K31/517 ,  A61K31/55 ,  A61K45/06 ,  C07D239/95 ,  C07D401/12 ,  C07D401/14

摘要： The disclosure relates to a compound of Formula (I):




or a pharmaceutically acceptable salt thereof wherein A, Ra to Rd, and R4 to R7, are as described herein, as well as compositions and methods of using such compounds.