公开(公告)号：US20200181615A1

公开(公告)日：2020-06-11

申请号：US16519721

申请日：2019-07-23

Applicant: Northwestern University

Inventor： William A. Muller ,  Bita F. Cyrus

IPC: C12N15/113 ,  A61K31/713 ,  A61K45/06 ,  A61K38/46 ,  A61K31/7105 ,  A61K38/00

Abstract: Provided herein are compositions and methods for the inhibition of endothelial cell kinesin light chain 1, variant 1 (KLC1C) expression and/or activity, and treatment or prevention of inflammation therewith.

公开(公告)号：US11304988B2

公开(公告)日：2022-04-19

申请号：US16256752

申请日：2019-01-24

Applicant: Northwestern University

Inventor： William A. Muller

IPC: A61K38/08 ,  A61P35/04

Abstract: Provided herein are compositions and methods for inhibiting tumor cell transendothelial migration by inhibition of kinesin light chain 1, variant 1 (KLC1C) expression and/or activity, and treatment or prevention of cancer and/or metastasis therewith.

公开(公告)号：US20220193182A1

公开(公告)日：2022-06-23

申请号：US17692471

申请日：2022-03-11

Applicant: Northwestern University

Inventor： William A. Muller

IPC: A61K38/08 ,  A61P35/04

Abstract: Provided herein are compositions and methods for inhibiting tumor cell transendothelial migration by inhibition of kinesin light chain 1, variant 1 (KLC1C) expression and/or activity, and treatment or prevention of cancer and/or metastasis therewith.

公开(公告)号：US20190224272A1

公开(公告)日：2019-07-25

申请号：US16256752

申请日：2019-01-24

Applicant: Northwestern University

Inventor： William A. Muller

IPC: A61K38/08 ,  A61P35/04

Abstract: Provided herein are compositions and methods for inhibiting tumor cell transendothelial migration by inhibition of kinesin light chain 1, variant 1 (KLC1C) expression and/or activity, and treatment or prevention of cancer and/or metastasis therewith.

公开(公告)号：US12116574B2

公开(公告)日：2024-10-15

申请号：US17474949

申请日：2021-09-14

Applicant: Northwestern University

Inventor： William A. Muller ,  Bita F. Cyrus

IPC: C12N15/113 ,  A61K31/7105 ,  A61K31/713 ,  A61K38/00 ,  A61K38/46 ,  A61K45/06

CPC classification number: C12N15/113 ,  A61K31/7105 ,  A61K31/713 ,  A61K38/005 ,  A61K38/46 ,  A61K45/06 ,  C12Y306/04004 ,  C12Y306/04005 ,  C12N2310/14 ,  C12N2310/531 ,  A61K31/713 ,  A61K2300/00 ,  A61K31/7105 ,  A61K2300/00

Abstract: Provided herein are compositions and methods for the inhibition of endothelial cell kinesin light chain 1, variant 1 (KLC1C) expression and/or activity, and treatment or prevention of inflammation therewith.

公开(公告)号：US20220259591A1

公开(公告)日：2022-08-18

申请号：US17474949

申请日：2021-09-14

Applicant: Northwestern University

Inventor： William A. Muller ,  Bita F. Cyrus

IPC: C12N15/113 ,  A61K45/06 ,  A61K31/713 ,  A61K38/00 ,  A61K31/7105 ,  A61K38/46

Abstract: Provided herein are compositions and methods for the inhibition of endothelial cell kinesin light chain 1, variant 1 (KLC1C) expression and/or activity, and treatment or prevention of inflammation therewith.

公开(公告)号：US11118180B2

公开(公告)日：2021-09-14

申请号：US16519721

申请日：2019-07-23

Applicant: Northwestern University

Inventor： William A. Muller ,  Bita F. Cyrus

IPC: C07H21/04 ,  C12N15/113 ,  A61K45/06 ,  A61K31/713 ,  A61K38/00 ,  A61K31/7105 ,  A61K38/46

Abstract: Provided herein are compositions and methods for the inhibition of endothelial cell kinesin light chain 1, variant 1 (KLC1C) expression and/or activity, and treatment or prevention of inflammation therewith.

公开(公告)号：US12226444B2

公开(公告)日：2025-02-18

申请号：US17692471

申请日：2022-03-11

Applicant: Northwestern University

Inventor： William A. Muller

IPC: A61K38/08 ,  A61P35/04

Abstract: Provided herein are compositions and methods for inhibiting tumor cell transendothelial migration by inhibition of kinesin light chain 1, variant 1 (KLC1C) expression and/or activity, and treatment or prevention of cancer and/or metastasis therewith.

公开(公告)号：US20170198290A1

公开(公告)日：2017-07-13

申请号：US15401794

申请日：2017-01-09

Applicant: Northwestern University

Inventor： William A. Muller ,  Bita F. Cyrus

IPC: C12N15/113 ,  A61K31/713 ,  A61K39/395 ,  A61K45/06 ,  C07K16/18

CPC classification number: C12N15/113 ,  A61K31/7105 ,  A61K31/713 ,  A61K38/005 ,  A61K38/46 ,  A61K45/06 ,  C12N2310/14 ,  C12N2310/531 ,  C12Y306/04004 ,  C12Y306/04005 ,  A61K2300/00

Abstract: Provided herein are compositions and methods for the inhibition of endothelial cell kinesin light chain 1, variant 1 (KLC1C) expression and/or activity, and treatment or prevention of inflammation therewith.