公开(公告)号：US12091685B2

公开(公告)日：2024-09-17

申请号：US17742033

申请日：2022-05-11

Applicant: New England Biolabs, Inc.

Inventor： Jennifer Ong ,  Vladimir Potapov ,  Kuo-Chan Hung ,  Haruichi Asahara ,  Shaorong Chong ,  George Tzertzinis

IPC: C12N9/12 ,  C12Q1/6858

CPC classification number: C12N9/1247 ,  C12Q1/6858 ,  C12Y207/07006

Abstract: A bacteriophage RNA polymerase variant is provided. In some embodiments, the variant may have increased thermostability relative to the corresponding wild type bacteriophage RNA polymerase and/or wild type T7 RNA polymerase. Compositions, kits and methods that employ the variant are also provided.

公开(公告)号：US20190024061A1

公开(公告)日：2019-01-24

申请号：US16068020

申请日：2017-01-12

Applicant: Jennifer ONG ,  Shaorong CHONG ,  Haruichi ASAHARA ,  Kuo-Chan HUNG ,  Vladimir PATAPOV ,  George TZERTZINIS ,  New England Biolabs, Inc.

Inventor： Jennifer Ong ,  Shaorong Chong ,  Haruichi Asahara ,  Kuo-Chan Hung ,  Vladimir Potapov ,  George Tzertzinis

IPC: C12N9/12 ,  C12P19/34

Abstract: A bacteriophage RNA polymerase variant is provided. In some embodiments, the variant may have increased thermostability relative to the corresponding wild type bacteriophage RNA polymerase and/or wild type T7 RNA polymerase. Compositions, kits and methods that employ the variant are also provided.

公开(公告)号：US11359184B2

公开(公告)日：2022-06-14

申请号：US16680014

申请日：2019-11-11

Applicant: New England Biolabs, Inc.

Inventor： Jennifer Ong ,  Vladimir Potapov ,  Kuo-Chan Hung ,  Haruichi Asahara ,  Shaorong Chong ,  George Tzertzinis

IPC: C12N9/12 ,  C12Q1/6858

Abstract: A bacteriophage RNA polymerase variant is provided. In some embodiments, the variant may have increased thermostability relative to the corresponding wild type bacteriophage RNA polymerase and/or wild type T7 RNA polymerase. Compositions, kits and methods that employ the variant are also provided.

公开(公告)号：US10519431B2

公开(公告)日：2019-12-31

申请号：US15594090

申请日：2017-05-12

Applicant: New England Biolabs, Inc.

Inventor： Jennifer Ong ,  Vladimir Potapov ,  Kuo-Chan Hung ,  Haruichi Asahara ,  Shaorong Chong ,  George Tzertzinis

IPC: C12N9/12 ,  C12Q1/6858

Abstract: A bacteriophage RNA polymerase variant is provided. In some embodiments, the variant may have increased thermostability relative to the corresponding wild type bacteriophage RNA polymerase and/or wild type T7 RNA polymerase. Compositions, kits and methods that employ the variant are also provided.

公开(公告)号：US20220275352A1

公开(公告)日：2022-09-01

申请号：US17742033

申请日：2022-05-11

Applicant: New England Biolabs, Inc.

Inventor： Jennifer Ong ,  Vladimir Potapov ,  Kuo-Chan Hung ,  Haruichi Asahara ,  Shaorong Chong ,  George Tzertzinis

IPC: C12N9/12 ,  C12Q1/6858

Abstract: A bacteriophage RNA polymerase variant is provided. In some embodiments, the variant may have increased thermostability relative to the corresponding wild type bacteriophage RNA polymerase and/or wild type T7 RNA polymerase. Compositions, kits and methods that employ the variant are also provided.

公开(公告)号：US20170247670A1

公开(公告)日：2017-08-31

申请号：US15594090

申请日：2017-05-12

Applicant: New England Biolabs, Inc.

Inventor： Jennifer Ong ,  Vladimir Potapov ,  Kuo-Chan Hung ,  Haruichi Asahara ,  Shaorong Chong ,  George Tzertzinis

IPC: C12N9/12 ,  C12Q1/68

CPC classification number: C12N9/1247 ,  C12Q1/6858 ,  C12Y207/07006

Abstract: A bacteriophage RNA polymerase variant is provided. In some embodiments, the variant may have increased thermostability relative to the corresponding wild type bacteriophage RNA polymerase and/or wild type T7 RNA polymerase. Compositions, kits and methods that employ the variant are also provided.