公开(公告)号：US20230357694A1

公开(公告)日：2023-11-09

申请号：US18300178

申请日：2023-04-13

Applicant: NDSU RESEARCH FOUNDATION

Inventor： DINESH RAMANATH KATTI ,  KALPANA S. KATTI ,  HANEESH JASUJA

IPC: C12M1/00 ,  C12M1/12 ,  C12M3/00

CPC classification number: C12M29/12 ,  C12M29/20 ,  C12M25/14 ,  C12M23/46

Abstract: A horizontal flow bioreactor facilitates continuous flow conditions to cells grown on a tissue engineered scaffold. More particularly, interstitial fluid flow conditions are mimicked around cells inside the body, thereby improving the mass transfer rates of cells and providing physical stimulus to the cells. Unlike the available perfusion based vertical bioreactors where flow is vertical through scaffolds, the horizontal flow reactor enables studies on attachment of cells to substrates, tissues, and bone mimetic scaffolds. The horizontal bioreactor further aides study of cell proliferation, cell migration, cell clustering, biology of cell growth, cell response, cell filtration techniques for capturing tumor cells, the testing of drugs, and drug delivery under flow conditions. The horizontal bioreactor can mimic in vivo conditions, epithelial to mesenchymal transition (EMT), and mesenchymal to epithelial transition (MET).

公开(公告)号：US20190255221A1

公开(公告)日：2019-08-22

申请号：US16260451

申请日：2019-01-29

Applicant: NDSU RESEARCH FOUNDATION

Inventor： KALPANA S. KATTI ,  DINESH RAMANATH KATTI

IPC: A61L27/46 ,  A61L27/54

Abstract: The invention relates to compositions useful for bone repair and methods of preparing the same. The invention is particularly suitable for bone repair of large bone defects. In an aspect of the invention, the compositions comprise a biocompatible polymer and a clay that form a scaffold. In a further aspect of the invention, the multiple scaffolds can be configured together to form scaffold blocks.

公开(公告)号：US20240350574A1

公开(公告)日：2024-10-24

申请号：US18640277

申请日：2024-04-19

Applicant: NDSU RESEARCH FOUNDATION

Inventor： KALPANA S. KATTI ,  DINESH RAMANATH KATTI ,  Kalidas Shetty ,  Dipayan Sarkar ,  Preetham Ravi

IPC: A61K36/53 ,  A61K36/41 ,  A61K36/45 ,  A61K47/02 ,  A61P35/04

CPC classification number: A61K36/53 ,  A61K36/41 ,  A61K36/45 ,  A61K47/02 ,  A61P35/04

Abstract: Compositions comprising phenolic phytochemicals of oregano, cranberry, or Rhodiola are provided. Compositions comprising a polymer, clay, and the phenolic phytochemicals are also provided. Methods of using the phenolic phytochemical compositions to treat a subject with bone metastasis are also provided, particularly methods of treating bone metastasis from breast or prostate cancer.