公开(公告)号：US11279966B2

公开(公告)日：2022-03-22

申请号：US15835420

申请日：2017-12-07

Applicant: NATIONAL TSING HUA UNIVERSITY

Inventor： Wen-Ching Wang ,  Hsing-Jien Kung ,  Chia-Han Chu ,  Jing-Moon Yang

IPC: C12Q1/26 ,  G16B15/20 ,  G16C20/64 ,  G16B15/30 ,  G16B15/00 ,  G16B35/00 ,  G16C20/60

Abstract: A method for identifying a compound that inhibits an activity of a histone lysine demethylase, in which the compound interacts with three sites of a pocket of the histone lysine demethylase generated by using a computer program, an alpha-ketoglutarate (AKG), a methylated lysine, and a NIQ.

公开(公告)号：US20150267241A1

公开(公告)日：2015-09-24

申请号：US14662220

申请日：2015-03-18

Applicant: NATIONAL TSING HUA UNIVERSITY

Inventor： Wen-Ching Wang ,  Hsing-Jien Kung ,  Chia-Han Chu ,  Jing-Moon Yang

IPC: C12Q1/26 ,  C40B30/02 ,  G01N33/50 ,  G06F19/16 ,  C12Q1/68

CPC classification number: C12Y114/11027 ,  C12Q1/26 ,  C40B30/02 ,  G01N2333/90245 ,  G01N2500/04 ,  G06F19/16

Abstract: The present invention relates to a method for identifying a compound that inhibits an activity of a histone lysine demethylase.

Abstract translation: 本发明涉及鉴定抑制组蛋白赖氨酸脱甲基酶活性的化合物的方法。

公开(公告)号：US20190117616A1

公开(公告)日：2019-04-25

申请号：US15789157

申请日：2017-10-20

Applicant: National Tsing Hua University

Inventor： Wen-Ching Wang ,  Hsing-Jien Kung

IPC: A61K31/352 ,  A61K9/127

Abstract: The present invention relates to a method for inhibiting activity of a protein selected from the group consisting of KDM4A, KDM4B, and KDM4C, comprising the step of exposing the protein to an effective inhibiting amount of a compound having the formula wherein R1 is H or C7O5H8; R2 is H, OH, or OCH3; and R3 is H or OH. The present invention also relates to a method for treating or lessening the severity of a disease, condition, or disorder in which modulation of KDM4A, KDM4B, or KDM4C is beneficial, which method comprises administering to a subject suffering from said disease, condition, or disorder a therapeutically-effective amount of: a) a compound having the formula wherein R1 is H or C7O5H8; R2 is H, OH, or OCH3; and R3 is H or OH; or b) a composition comprising the compound and a pharmaceutically acceptable adjuvant, vehicle, or carrier.

公开(公告)号：US20180087118A1

公开(公告)日：2018-03-29

申请号：US15835420

申请日：2017-12-07

Applicant: NATIONAL TSING HUA UNIVERSITY

Inventor： Wen-Ching Wang ,  Hsing-Jien Kung ,  Chia-Han Chu ,  Jing-Moon Yang

IPC: C12Q1/26 ,  C40B30/02 ,  G06F19/16

CPC classification number: C12Y114/11027 ,  C12Q1/26 ,  G01N2333/90245 ,  G01N2500/04 ,  G16B15/00 ,  G16B35/00 ,  G16C20/60

Abstract: A method for identifying a compound that inhibits an activity of a histone lysine demethylase, in which the compound interacts with three sites of a pocket of the histone lysine demethylase generated by using a computer program, an alpha-ketoglutarate (AKG), a methylated lysine, and a NIQ.

公开(公告)号：US09890434B2

公开(公告)日：2018-02-13

申请号：US14662220

申请日：2015-03-18

Applicant: NATIONAL TSING HUA UNIVERSITY

Inventor： Wen-Ching Wang ,  Hsing-Jien Kung ,  Chia-Han Chu ,  Jing-Moon Yang

IPC: C12Q1/26 ,  C40B30/02 ,  G06F19/16

CPC classification number: C12Y114/11027 ,  C12Q1/26 ,  C40B30/02 ,  G01N2333/90245 ,  G01N2500/04 ,  G06F19/16

Abstract: The present invention relates to a method for identifying a compound that inhibits an activity of a histone lysine demethylase.