公开(公告)号：US07649001B2

公开(公告)日：2010-01-19

申请号：US10524452

申请日：2003-08-11

申请人： Mitsuru Shiraishi ,  Takahito Hara ,  Masami Kusaka ,  Naoyuki Kanzaki ,  Satoshi Yamamoto ,  Toshio Miyawaki

发明人： Mitsuru Shiraishi ,  Takahito Hara ,  Masami Kusaka ,  Naoyuki Kanzaki ,  Satoshi Yamamoto ,  Toshio Miyawaki

IPC分类号： A61K31/454 ,  C07D409/02

CPC分类号： C07C255/52 ,  C07C35/52 ,  C07C217/04 ,  C07C255/53 ,  C07C255/54 ,  C07C255/56 ,  C07C2601/08 ,  C07C2601/10 ,  C07D207/06 ,  C07D207/08 ,  C07D207/10 ,  C07D207/12 ,  C07D207/14 ,  C07D207/16 ,  C07D207/22 ,  C07D207/24 ,  C07D209/46 ,  C07D211/22 ,  C07D211/28 ,  C07D211/34 ,  C07D211/42 ,  C07D211/46 ,  C07D211/60 ,  C07D211/62 ,  C07D211/74 ,  C07D231/08 ,  C07D261/04 ,  C07D265/02 ,  C07D267/10 ,  C07D295/073 ,  C07D295/112 ,  C07D295/155 ,  C07D303/46 ,  C07D307/79 ,  C07D333/54 ,  C07D405/04 ,  C07D409/04 ,  C07D491/10

摘要： The present invention provides a compound represented by the general formula: [wherein Ring A represents an optionally substituted 5- to 8-membered ring, Ring B represents a further optionally substituted 4- to 10-membered ring, Ring C represents a further optionally substituted benzene ring, X1 represents carbon atom, X2 represents a carbon atom, an oxygen atom, etc., W represents a nitrogen atom, etc., Y11 represents a group represented by the formula CR2R3′ (wherein R2 represents a hydrogen atom, a cyano group, a nitro group, etc., and R3′ represents a hydrogen atom, a cyano group, a nitro group, etc., respectively), Y21 represents a group represented by the formula CR4R5′ (wherein R4 represents a hydrogen atom, a cyano group, a nitro group, etc., and R5′ represents a hydrogen atom, a cyano group, a nitro group, etc., respectively), etc., and R1 represents an electron-withdrawing group, respectively. The formula represents a single bond or a double bond] or a salt thereof, which is useful as an androgen receptor modulator.

摘要翻译： 本发明提供由以下通式表示的化合物：其中环A表示任选取代的5-至8-元环，环B表示另外任选取代的4-至10-元环，环C表示另外任选取代的 苯环，X1表示碳原子，X2表示碳原子，氧原子等，W表示氮原子等，Y11表示由式CR2R3'表示的基团（其中R2表示氢原子，氰基 基，硝基等，R3'分别表示氢原子，氰基，硝基等），Y21表示由式CR4R5'表示的基团（其中R4表示氢原子， 氰基，硝基等，R5'分别表示氢原子，氰基，硝基等），R1表示吸电子基团。 公式表示单键或双键]或其盐，其可用作雄激素受体调节剂。

公开(公告)号：US07262185B2

公开(公告)日：2007-08-28

申请号：US10486002

申请日：2002-08-07

申请人： Mitsuru Shiraishi ,  Masanori Baba ,  Masaki Seto ,  Yoshio Aramaki ,  Naoyuki Kanzaki ,  Naoki Miyamoto ,  Yuji Iizawa

发明人： Mitsuru Shiraishi ,  Masanori Baba ,  Masaki Seto ,  Yoshio Aramaki ,  Naoyuki Kanzaki ,  Naoki Miyamoto ,  Yuji Iizawa

IPC分类号： A61P43/00 ,  A61K31/55 ,  A61K31/18 ,  C07D401/12 ,  C07D417/12

CPC分类号： C07D223/16 ,  A61K31/18 ,  A61K31/55

摘要： The present invention provides a novel benzazepine derivative represented by formula: wherein, R1 is a 5- or 6-membered aromatic ring, R2 is lower alkyl group, etc., Y is an optionally substituted imino group, ring A and ring B are independently an optionally substituted aromatic ring, W is formula —W1—X2—W2— (W1 and W2 are independently S(O)m1 (m1 is 0, 1, or 2), etc., and X2 is an optionally substituted alkylene group etc.), a preparation method and use thereof.

摘要翻译： 本发明提供一种由式表示的新的苯并氮杂衍生物：其中R 1是5或6元芳环，R 2是低级烷基等。 Y是任选取代的亚氨基，环A和环B独立地是任选取代的芳环，W是式-W 1 -O 2 - （W 1和O 2）独立地为S（O）m1（m1为0,1或2） 等等，X 2是任选取代的亚烷基等），其制备方法和用途。

公开(公告)号：US07159938B1

公开(公告)日：2007-01-09

申请号：US11178506

申请日：2005-07-12

申请人： Mitsuru Shiraishi

发明人： Mitsuru Shiraishi

IPC分类号： A47C7/62

CPC分类号： B60N2/70 ,  B60R11/0217 ,  B60R2011/0015 ,  H04R1/025 ,  H04R1/26 ,  H04R5/023 ,  H04R2499/13

摘要： An acoustic structure of seat back in which speaker units are provided in a padding of the seat back. The padding includes: a frontal backrest surface area which is recessed backwardly of the seat back; and securing holes formed in that frontal backrest surface area. An enclosure of each speaker unit, in which each speaker is securely accommodated, is secured in each of the securing holes. A sound-conductive cushion element is juxtaposed on the foregoing recessed frontal backrest surface area of padding so as to lie on a frontal side of each of the speaker units. The sound-conductive cushion element may be of a network structure to not only provide an improved back support touch, but also achieve an improved conductivity of sounds from the speaker units to a user's back portion. Those padding and sound-conductive cushion element are covered with a trim cover assembly.

摘要翻译： 扬声器单元设置在座椅靠背的衬垫中的座椅靠背的声学结构。 该衬垫包括：前座椅靠背表面区域，其位于座椅靠背的后方; 并且固定在该正面靠背表面区域中形成的孔。 每个扬声器单元的围绕每个扬声器被牢固地容纳在每个扬声器单元的每个固定孔中。 导电缓冲元件与前述凹进的前侧靠背表面区域并列放置，以便位于每个扬声器单元的正面上。 导电缓冲元件可以是网络结构，不仅提供改进的后支撑触摸，而且还实现从扬声器单元到用户的后部的改进的声音导电性。 那些填充和导电的缓冲元件被一个装饰罩组件覆盖。

公开(公告)号：US20060160864A1

公开(公告)日：2006-07-20

申请号：US10544275

申请日：2004-02-02

申请人： Mitsuru Shiraishi ,  Masaki Seto ,  Katsuji Aikawa ,  Naoyuki Kanzaki ,  Masanori Baba

发明人： Mitsuru Shiraishi ,  Masaki Seto ,  Katsuji Aikawa ,  Naoyuki Kanzaki ,  Masanori Baba

IPC分类号： A61K31/4439 ,  A61K31/4178 ,  A61K31/40 ,  C07D403/02

CPC分类号： C07D213/73

摘要： A compound represented by the formula: wherein R1 is a 5- or 6-membered ring; R3 is a hydrogen atom, a lower alkyl group or a lower alkoxy group; R7 and R8 are each a hydrogen atom or a lower alkyl group; Z1 is another 5- or 6-membered aromatic ring; Z2 is a group represented by -Z2a-W1-Z2b- [wherein Z2a and Z2b are each O, S(O)m (wherein m is 0, 1 or 2), an imino group or a bond, and W1 is an alkylene chain]; X is CR (wherein R is a hydrogen atom, a lower alkyl group, a lower alkoxy group, an acyl group, or R and adjacent R4 may form a 5- or 6-membered alicyclic heterocyclic group) or N; R4 is NR5R6 (wherein R5 and R6 are each a hydrogen atom, a hydrocarbon group, a heterocyclic group or an acyl group), or R5 and R6 are bonded to each other to form a heterocyclic group of NR5R6; and R2 is (1) an amino group which may be a quaternary ammonium or oxide, (2) a nitrogen-containing heterocyclic group which may contain a sulfur atom or an oxygen atom as the ring-constituting atom, in which the nitrogen atom may be converted to a quaternary ammonium or an oxide, or the like; or a salt thereof. The compound has excellent CCR5 antagonistic activity and thus is useful as a prophylactic and/or therapeutic medicine for HIV infection into human peripheral blood monocyte, especially for AIDS.

摘要翻译： 由下式表示的化合物：其中R 1是5或6元环; R 3是氢原子，低级烷基或低级烷氧基; R 7和R 8各自为氢原子或低级烷基; Z 1是另一个5或6元芳环; Z 2是由-Z 2a表示的基团，其中Z ^{2a和Z 2b各自为O，S（O）m（其中m为0,1或2），亚氨基或键， 和W 1是亚烷基链]; X是CR（其中R是氢原子，低级烷基，低级烷氧基，酰基或R和相邻的R 4）可以形成5-或6-元脂环族杂环基 ）或N; R 4是NR 5 R 6（其中R 5和R 6）是 各自为氢原子，烃基，杂环基或酰基）或R 5和R 6彼此键合以形成NR的杂环基 5＆lt; 5＆gt; 6＆lt; 6＆gt; 和R 2是（1）可以是季铵或氧化物的氨基，（2）可以含有硫原子或氧原子的含氮杂环基作为环的构成 原子，其中氮原子可以转化成季铵或氧化物等; 或其盐。 该化合物具有优异的CCR5拮抗活性，因此可用作HIV感染人外周血单核细胞，特别是用于艾滋病的预防和/或治疗药物。}

公开(公告)号：US06655244B2

公开(公告)日：2003-12-02

申请号：US09335879

申请日：1999-06-18

申请人： Mitsuru Shiraishi ,  Koichi Oikawa ,  Hitoshi Komoriya ,  Yutaka Nakamura ,  Takao Hirahara

发明人： Mitsuru Shiraishi ,  Koichi Oikawa ,  Hitoshi Komoriya ,  Yutaka Nakamura ,  Takao Hirahara

IPC分类号： B23B100

CPC分类号： G11B19/20 ,  Y10T82/10 ,  Y10T82/2571 ,  Y10T82/27 ,  Y10T82/30

摘要： A centering apparatus for centering a disk about a center member such as a shaft or hub includes a plurality of pairs of actuator units. The actuator units of each of the pairs faces each other through the disk. Each of the actuator units has a member which moves linearly and can come into contact with the disk.

摘要翻译： 用于使圆盘围绕中心构件例如轴或毂定心的定心装置包括多对致动器单元。 每对的致动器单元通过盘彼此面对。 每个致动器单元具有线性移动并且可以与盘接触的构件。

公开(公告)号：US06350749B1

公开(公告)日：2002-02-26

申请号：US09601866

申请日：2000-08-08

申请人： Mitsuru Shiraishi ,  Shoji Fukumoto ,  Keiji Kusumoto

发明人： Mitsuru Shiraishi ,  Shoji Fukumoto ,  Keiji Kusumoto

IPC分类号： C07D20908

CPC分类号： C07D221/04 ,  C07D209/06 ,  C07D209/88 ,  C07D215/38 ,  C07D215/60 ,  C07D231/56 ,  C07D237/28 ,  C07D239/74 ,  C07D261/20 ,  C07D307/79 ,  C07D307/84 ,  C07D401/04 ,  C07D405/04 ,  C07D409/04 ,  C07D417/04

摘要： The present invention is to provide a compound of the formula: wherein the ring A is an optionally substituted 5- to 6-membered aromatic heterocyclic ring, the ring B an optionally substituted 5- to 6-membered aromatic homocyclic ring or an optionally substituted 5- to 6-membered aromatic heterocyclic ring, R1 is a hydrogen atom, a hydroxy group or a lower alkyl group, and n is 0 or 1, or a salt thereof, which is effective for the prevention or treatment of ischemic cardiac disease, etc., and which is useful as an agent for preventing or treating ischemic cardiac disease, etc. such as myocardial infarction, arrhythmia, etc.

摘要翻译： 本发明提供下式的化合物：其中环A为任选取代的5至6元芳族杂环，环B为任选取代的5至6元芳族碳环或任选取代的5 至6元芳族杂环，R 1为氢原子，羟基或低级烷基，n为0或1，或其盐对预防或治疗缺血性心脏病有效等。 可用作预防或治疗心肌梗死，心律失常等缺血性心脏病等的药剂。

公开(公告)号：US5733929A

公开(公告)日：1998-03-31

申请号：US594328

申请日：1996-01-30

申请人： Mitsuru Shiraishi ,  Yasuko Ashida ,  Tatsumi Matsumoto

发明人： Mitsuru Shiraishi ,  Yasuko Ashida ,  Tatsumi Matsumoto

IPC分类号： C07D333/22 ,  A61K31/12 ,  A61K31/122 ,  A61K31/19 ,  A61K31/20 ,  A61K31/38 ,  A61K31/381 ,  A61P27/16 ,  A61P37/08 ,  A61P43/00 ,  C07C59/52 ,  C07C59/82 ,  A01N37/00

CPC分类号： A61K31/122 ,  A61K31/12 ,  A61K31/19 ,  A61K31/20 ,  A61K31/38

摘要： There is disclosed a pharmaceutical composition for treating or preventing allergic rhinitis which comprises a quinone or hydroquinone derivative having thromboxane A.sub.2 receptor antagonism. This compound is hardly inactivated by in vivo metabolism and can maintain its effective blood level for a long term and exhibit excellent pharmacological activity in a low dose.

摘要翻译： 公开了一种用于治疗或预防过敏性鼻炎的药物组合物，其包含具有血栓烷A 2受体拮抗作用的醌或氢醌衍生物。 该化合物几乎不被体内代谢失活，并且可以长期保持其有效的血液水平，并且在低剂量下表现出优异的药理活性。

公开(公告)号：US4166178A

公开(公告)日：1979-08-28

申请号：US897157

申请日：1978-04-17

申请人： Susumu Tsushima ,  Michiyuki Sendai ,  Mitsuru Shiraishi ,  Norichika Matsumoto

发明人： Susumu Tsushima ,  Michiyuki Sendai ,  Mitsuru Shiraishi ,  Norichika Matsumoto

IPC分类号： A61K31/545 ,  C07D501/20 ,  C07D501/26

CPC分类号： C07D501/18 ,  C07D501/26

摘要： Novel 3-acyloxymethyl-cephem compounds of the formula: ##STR1## wherein R.sup.1 is hydrogen or an acyl group; X is a divalent group consisting of a carbon chain having 2 to 3 carbon atoms and a carbonyl or sulfonyl group at one terminal end thereof, said divalent group being either substituted or unsubstituted on the carbon chain; and Z is an organic acid residue, and salts thereof were found to be useful as starting materials for preparing cephalosporins of the formula: ##STR2## wherein R.sup.2 stands for a residue of a nucleophilic compound and R.sup.1 has the same meaning as above.

公开(公告)号：US07371772B2

公开(公告)日：2008-05-13

申请号：US10484762

申请日：2002-08-07

申请人： Mitsuru Shiraishi ,  Masanori Baba ,  Katsuji Aikawa ,  Naoyuki Kanzaki ,  Masaki Seto ,  Yuji Iizawa

发明人： Mitsuru Shiraishi ,  Masanori Baba ,  Katsuji Aikawa ,  Naoyuki Kanzaki ,  Masaki Seto ,  Yuji Iizawa

IPC分类号： A61P31/18 ,  A61K31/335 ,  A61K31/395 ,  A61K31/4178 ,  A61K31/4196 ,  C07D313/20 ,  C07D225/06 ,  C07D403/12 ,  C07D405/14 ,  C07D403/14

CPC分类号： A61K31/4196 ,  A61K31/395 ,  A61K31/4178 ,  C07D225/06 ,  C07D313/20 ,  C07D403/12 ,  C07D405/12 ,  C07D407/12

摘要： The present invention provides a new cyclic compound having a CCR antagonist activity, especially a CCR5 antagonist activity, and the use thereof. The compound of the present invention is represented by the formula: wherein, R1 is a 5- to 6-membered ring group which may be substituted; X1 is a bond or the like; ring A is a 5- to 6-membered ring group which may be substituted; ring B is a 8- to 10-membered ring group which may be substituted; X2 is a bivalent group of 1 to 4 atoms; Z1 is a bivalent cyclic ring group or the like; Z2 is a bond or the like; and R2 is an amino group, a nitrogen-containing heterocyclic group which may be substituted or the like, or a salt thereof.

公开(公告)号：US20070024097A1

公开(公告)日：2007-02-01

申请号：US11178506

申请日：2005-07-12

申请人： Mitsuru Shiraishi

发明人： Mitsuru Shiraishi

IPC分类号： A47C31/00

CPC分类号： B60N2/70 ,  B60R11/0217 ,  B60R2011/0015 ,  H04R1/025 ,  H04R1/26 ,  H04R5/023 ,  H04R2499/13

摘要： An acoustic structure of seat back in which speaker units are provided in a padding of the seat back. The padding includes: a frontal backrest surface area which is recessed backwardly of the seat back; and securing holes formed in that frontal backrest surface area. An enclosure of each speaker unit, in which each speaker is securely accommodated, is secured in each of the securing holes. A sound-conductive cushion element is juxtaposed on the foregoing recessed frontal backrest surface area of padding so as to lie on a frontal side of each of the speaker units. The sound-conductive cushion element may be of a network structure to not only provide an improved back support touch, but also achieve an improved conductivity of sounds from the speaker units to a user's back portion. Those padding and sound-conductive cushion element are covered with a trim cover assembly.

摘要翻译： 扬声器单元设置在座椅靠背的衬垫中的座椅靠背的声学结构。 该衬垫包括：前座椅靠背表面区域，其位于座椅靠背的后方; 并且固定在该正面靠背表面区域中形成的孔。 每个扬声器单元的围绕每个扬声器被牢固地容纳在每个扬声器单元的每个固定孔中。 导电缓冲元件与前述凹进的前侧靠背表面区域并列放置，以便位于每个扬声器单元的正面上。 导电缓冲元件可以是网络结构，不仅提供改进的后支撑触摸，而且还实现从扬声器单元到用户的后部的改进的声音导电性。 那些填充和导电的缓冲元件被一个装饰罩组件覆盖。