公开(公告)号：US20240034733A1

公开(公告)日：2024-02-01

申请号：US18034852

申请日：2021-11-02

申请人： Mirati Therapeutics, Inc. ,  Array BioPharma Inc.

发明人： Matthew Arnold Marx ,  John David Lawson ,  Patrick Michael Doerner Barbaur ,  James Francis Blake ,  Jay Bradford Fell ,  John Peter Fischer ,  Bradley J. Newhouse ,  Phong Nguyen ,  Jacob M. O'Leary ,  Spencer Pajk ,  Martha E. Rodriguez ,  Tony Pisal Tang

IPC分类号： C07D471/08 ,  C07D519/00 ,  C07D403/12

CPC分类号： C07D471/08 ,  C07D519/00 ,  C07D403/12

摘要： The present invention relates to compounds that inhibit KRas G12D. In particular, the present invention relates to compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor.

公开(公告)号：US20230357277A1

公开(公告)日：2023-11-09

申请号：US18027300

申请日：2021-09-21

申请人： Mirati Therapeutics, Inc. ,  Array BioPharma Inc.

发明人： Xiaolun Wang ,  Matthew Arnold Marx ,  Shelley Allen ,  Mark Joseph Chicarelli ,  Joshua Ryan Dahlke ,  Donghua Dai ,  Jay Bradford Fell ,  John Peter Fischer ,  Michael Christopher Hilton ,  Dean Russell Kahn ,  Macedonio Junior Mejia ,  Phong Nguyen ,  Spencer Pajk ,  Martha E. Rodriguez ,  Pavel Yu Savechenkov ,  Tony Pisal Tang

IPC分类号： C07D519/00 ,  A61P35/00

CPC分类号： C07D519/00 ,  A61P35/00

摘要： The present invention relates to compounds that inhibit KRas G12D. In particular, the present invention relates to compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor.

公开(公告)号：US20230339976A1

公开(公告)日：2023-10-26

申请号：US18020013

申请日：2021-08-03

申请人： Mirati Therapeutics, Inc. ,  Array BioPharma Inc.

发明人： Xiaolun Wang ,  Matthew Arnold Marx ,  John David Lawson ,  Shelley Allen ,  Patrick Michael Barbour ,  James Francis Blake ,  Joshua Ryan Dahlke ,  Donghua Dai ,  Jay Bradford Fell ,  John Peter Fischer ,  Sherif Hosam Hassanien ,  Michael Christopher Hilton ,  Macedonio Junior Mejia ,  Jacob Matthew O’Leary ,  Tony Pisal Tang

IPC分类号： C07D471/04 ,  C07D519/00

CPC分类号： C07D519/00 ,  C07D471/04

摘要： The present invention relates to compounds that inhibit KRas G12D. In particular, the present invention relates to compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor.