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公开(公告)号：US20230357277A1
公开(公告)日：2023-11-09
申请号：US18027300
申请日：2021-09-21
Applicant: Mirati Therapeutics, Inc. , Array BioPharma Inc.
Inventor： Xiaolun Wang , Matthew Arnold Marx , Shelley Allen , Mark Joseph Chicarelli , Joshua Ryan Dahlke , Donghua Dai , Jay Bradford Fell , John Peter Fischer , Michael Christopher Hilton , Dean Russell Kahn , Macedonio Junior Mejia , Phong Nguyen , Spencer Pajk , Martha E. Rodriguez , Pavel Yu Savechenkov , Tony Pisal Tang
IPC: C07D519/00 , A61P35/00
CPC classification number: C07D519/00 , A61P35/00
Abstract: The present invention relates to compounds that inhibit KRas G12D. In particular, the present invention relates to compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor.
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公开(公告)号：US20230339976A1
公开(公告)日：2023-10-26
申请号：US18020013
申请日：2021-08-03
Applicant: Mirati Therapeutics, Inc. , Array BioPharma Inc.
Inventor： Xiaolun Wang , Matthew Arnold Marx , John David Lawson , Shelley Allen , Patrick Michael Barbour , James Francis Blake , Joshua Ryan Dahlke , Donghua Dai , Jay Bradford Fell , John Peter Fischer , Sherif Hosam Hassanien , Michael Christopher Hilton , Macedonio Junior Mejia , Jacob Matthew O’Leary , Tony Pisal Tang
IPC: C07D471/04 , C07D519/00
CPC classification number: C07D519/00 , C07D471/04
Abstract: The present invention relates to compounds that inhibit KRas G12D. In particular, the present invention relates to compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor.
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公开(公告)号：US20230077225A1
公开(公告)日：2023-03-09
申请号：US17869575
申请日：2022-07-20
Applicant: Mirati Therapeutics, Inc. , Array BioPharma Inc.
Inventor： Xiaolun Wang , Aaron Craig Burns , James Gail Christensen , John Michael Ketcham , John David Lawson , Matthew Arnold Marx , Christopher Ronald Smith , Shelley Allen , James F. Blake , Mark Joseph Chicarelli , Joshua Ryan Dahlke , Donghua Dai , Jay Bradford Fell , John Peter Fischer , Macedonio J. Mejia , Brad Newhouse , Phong Nguyen , Jacob Matthew O'Leary , Spencer Pajk , Martha E. Rodriguez , Pavel Savechenkov , Tony P. Tang , Guy P.A. Vigers , Qian Zhao , Dean Russell Kahn , John Gaudino , Michael Christopher Hilton
IPC: C07D519/00
Abstract: The present invention relates to compounds that inhibit KRas G12D. In particular, the present invention relates to compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor.
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公开(公告)号：US20240309020A1
公开(公告)日：2024-09-19
申请号：US18644056
申请日：2024-04-23
Applicant: Mirati Therapeutics, Inc. , Array BioPharma Inc.
Inventor： Xiaolun Wang , Aaron Craig Burns , James Gail Christensen , John Michael Ketcham , John David Lawson , Matthew Arnold Marx , Christopher Ronald Smith , Shelley Allen , James F. Blake , Mark Joseph Chicarelli , Joshua Ryan Dahlke , Donghua Dai , Jay Bradford Fell , John Peter Fischer , Macedonio J. Mejia , Brad Newhouse , Phong Nguyen , Jacob Matthew O'Leary , Spencer Pajk , Martha E. Rodriguez , Pavel Savechenkov , Tony P. Tang , Guy P.A. Vigers , Qian Zhao , Dean Russell Kahn , John Gaudino , Michael Christopher Hilton
IPC: C07D519/00
CPC classification number: C07D519/00
Abstract: The present invention relates to compounds that inhibit KRas G12D. In particular, the present invention relates to compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor.
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公开(公告)号：US11964989B2
公开(公告)日：2024-04-23
申请号：US17869575
申请日：2022-07-20
Applicant: Mirati Therapeutics, Inc. , Array BioPharma Inc.
Inventor： Xiaolun Wang , Aaron Craig Burns , James Gail Christensen , John Michael Ketcham , John David Lawson , Matthew Arnold Marx , Christopher Ronald Smith , Shelley Allen , James F. Blake , Mark Joseph Chicarelli , Joshua Ryan Dahlke , Donghua Dai , Jay Bradford Fell , John Peter Fischer , Macedonio J. Mejia , Brad Newhouse , Phong Nguyen , Jacob Matthew O'Leary , Spencer Pajk , Martha E. Rodriguez , Pavel Savechenkov , Tony P. Tang , Guy P.A. Vigers , Qian Zhao , Dean Russell Kahn , John Gaudino , Michael Christopher Hilton
IPC: C07D519/00
CPC classification number: C07D519/00
Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I):
or a pharmaceutically acceptable salt thereof.-
Patent Agency Ranking
公开(公告)号：US20230279025A1
公开(公告)日：2023-09-07
申请号：US18015691
申请日：2021-02-25
Applicant: Mirati Therapeutics, Inc. , Array BioPharma Inc.
Inventor： Xiaolun Wang , Aaron Craig Burns , James Gail Christensen , John Michael Ketcham , John David Lawson , Matthew Arnold Marx , Christopher Ronald Smith , Shelley Allen , James Francis Blake , Mark Joseph Chicarelli , Joshua Ryan Dahlke , Donghua Dai , Jay Bradford Fell , John Peter Fischer , Macedonio J. Mejia , Brad Newhouse , Phong Nguyen , Jacob Matthew O'Leary , Spencer Pajk , Martha E. Rodriguez , Pavel Savechenkov , Tony P. Tang , Guy P.A. Vigers , Qian Zhao , Dean Russell Kahn , John Gaudino , Michael Christopher Hilton
IPC: C07D519/00
CPC classification number: C07D519/00 , C07B2200/05
Abstract: The present invention relates to compounds that inhibit KRas G12D, In particular, the present invention relates to compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor.
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公开(公告)号：US11453683B1
公开(公告)日：2022-09-27
申请号：US17005004
申请日：2020-08-27
Applicant: Mirati Therapeutics, Inc. , Array BioPharma Inc.
Inventor： Xiaolun Wang , Aaron Craig Burns , James Gail Christensen , John Michael Ketcham , John David Lawson , Matthew Arnold Marx , Christopher Ronald Smith , Shelley Allen , James F. Blake , Mark Joseph Chicarelli , Joshua Ryan Dahlke , Donghua Dai , Jay Bradford Fell , John Peter Fischer , Macedonio J. Mejia , Brad Newhouse , Phong Nguyen , Jacob Matthew O'Leary , Spencer Pajk , Martha E. Rodriguez , Pavel Savechenkov , Tony P. Tang , Guy P. A. Vigers , Qian Zhao , Dean Russell Kahn , John Gaudino , Michael Christopher Hilton
IPC: C07D519/00
Abstract: Compounds that inhibit KRas G12D; in particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.
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![PYRAZOLO[3,4-b]PYRIDINE COMPOUNDS AS INHIBITORS OF TAM AND MET KINASES](/abs-image/US/2024/05/30/US20240174666A1/abs.jpg.150x150.jpg)
公开(公告)号：US20240174666A1
公开(公告)日：2024-05-30
申请号：US18457795
申请日：2023-08-29
Applicant: Array BioPharma Inc.
Inventor： Ronald Jay Hinklin , Shelley Allen , Patrick Michael Doerner Barbour , Adam Wade Cook , Joshua Ryan Dahlke , John Joseph Gaudino , Ellen Ruth Laird , Oren Teague McNulty , Qian Zhao
IPC: C07D471/04
CPC classification number: C07D471/04
Abstract: Provided herein are compounds of the Formula I:
and stereoisomers, tautomers and pharmaceutically acceptable salts thereof, wherein R1, R2, R9, X1 and G are as defined herein, which are inhibitors of one or more TAM kinases and/or c-Met kinase, and are useful in the treatment and prevention of diseases which can be treated with a TAM kinase inhibitor and/or a c-Met kinase inhibitor.-
![4,6-SUBSTITUTED-PYRAZOLO[1,5-a]PYRAZINES AS JANUS KINASE INHIBITORS](/abs-image/US/2019/06/13/US20190177328A1/abs.jpg.150x150.jpg)
公开(公告)号：US20190177328A1
公开(公告)日：2019-06-13
申请号：US16212493
申请日：2018-12-06
Applicant: Array BioPharma Inc. , Celgene Corporation
Inventor： Shelley Allen , Mark Laurence Boys , Mark J. Chicarelli , Jay Bradford Fell , John P. Fischer , John Gaudino , Erik James Hicken , Ronald Jay Hinklin , Christopher F. Kraser , Ellen Laird , John E. Robinson , Tony P. Tang , Laurence E. Burgess , Robert Andrew Rieger , Jed Pheneger , Yoshitaka Satoh , Katerina Leftheris , Raj K. Raheja , Brydon L. Bennett
IPC: C07D487/04 , A61K45/06 , A61K31/4985 , A61K31/5377
Abstract: Compounds of Formula I: and stereoisomers and pharmaceutically acceptable salts and solvates thereof in which R1, R2, R3 and R4 have the meanings given in the specification, are inhibitors of one or more JAK kinases and are useful in the treatment of JAK kinase-associated diseases and disorders, such as autoimmune diseases, inflammatory diseases, rejection of transplanted organs, tissues and cells, as well as hematologic disorders and malignancies and their co-morbidities.
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![4,6-substituted-pyrazolo[1,5-a]pyrazines as janus kinase inhibitors](/abs-image/US/2019/01/29/US10189845B2/abs.jpg.150x150.jpg)
公开(公告)号：US10189845B2
公开(公告)日：2019-01-29
申请号：US15532937
申请日：2015-12-04
Applicant: ARRAY BIOPHARMA INC. , CELGENE CORPORATION
Inventor： Shelley Allen , Mark Laurence Boys , Mark J. Chicarelli , Jay Bradford Fell , John P. Fischer , John Gaudino , Erik James Hicken , Ronald Jay Hinklin , Christopher F. Kraser , Ellen Laird , John E. Robinson , Tony P. Tang , Laurence E. Burgess , Robert Andrew Rieger , Jed Pheneger , Yoshitaka Satoh , Katerina Leftheris , Raj K. Raheja , Brydon L. Bennett
IPC: A61K45/06 , C07D487/04 , A61K31/4985 , A61K31/5377
Abstract: Compounds of Formula I: and stereoisomers and pharmaceutically acceptable salts and solvates thereof in which R1, R2, R3 and R4 have the meanings given in the specification, are inhibitors of one or more JAK kinases and are useful in the treatment of JAK kinase-associated diseases and disorders, such as autoimmune diseases, inflammatory diseases, rejection of transplanted organs, tissues and cells, as well as hematologic disorders and malignancies and their co-morbidities.
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