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公开(公告)号：US11031230B2
公开(公告)日：2021-06-08
申请号：US16306809
申请日：2017-06-05
申请人： MICROMASS UK LIMITED
摘要： A method of analysing a sample is disclosed that comprises surveying a sample in a first mode of operation by directing a spray of charged droplets onto the sample, determining one or more regions of interest in the sample, and analysing the one or more regions of interest in a second different mode of operation by directing a spray of charged droplets onto the sample. The spot size of the spray of charged droplets at a point of impact with the sample may be varied.
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2.发明授权Mass spectrometer, control system and methods of operating and assembling a mass spectrometer 有权质谱仪，控制系统和操作和组装质谱仪的方法公开(公告)号：US09384955B2
公开(公告)日：2016-07-05
申请号：US14306269
申请日：2014-06-17
申请人： Micromass UK Limited
发明人： Phillip Edward Young , Paul Doorbar , Peter G. Spreadbury , Richard Newton , Alan McKinnon , Richard B. Moulds , Richard Chapman , Anthony J. Gilbert
CPC分类号： H01J49/022 , H01J49/0027 , Y10T29/49117
摘要： A mass spectrometer and methods for controlling a mass spectrometer are provided. In an exemplary embodiment, the mass spectrometer includes a plurality of discrete functional modules, each operable to perform a predetermined function of the mass spectrometer, wherein the modules are individually addressable and connected in a network. The mass spectrometer can also include a scheduler operable to introduce discrete packets of instructions to the network at predetermined times to instruct at least one module to perform a predetermined operation.
摘要翻译： 提供质谱仪和控制质谱仪的方法。 在示例性实施例中，质谱仪包括多个离散功能模块，每个功能模块可操作以执行质谱仪的预定功能，其中模块可单独寻址并在网络中连接。 质谱仪还可以包括调度器，其可操作以在预定时间将离散指令分组引入网络，以指示至少一个模块执行预定操作。
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公开(公告)号：US20160027626A1
公开(公告)日：2016-01-28
申请号：US14776036
申请日：2014-03-14
申请人： MICROMASS UK LIMITED
IPC分类号： H01J49/00
CPC分类号： H01J49/0004 , H01J49/0031 , H01J49/0036
摘要： A method of ion imaging is disclosed comprising scanning a sample and acquiring first mass spectral data related to a first pixel location at a first spatial resolution and determining whether or not the first mass spectral data satisfies a condition. If it is determined that the first mass spectral data does satisfy the condition then the first mass spectral data is stored, recorded or prioritized. If it is determined that the first mass spectral data does not satisfy the condition then the first mass spectral data is discarded or downgraded. Scanning of the sample then continues at the first spatial resolution and further mass spectral data related to further pixel locations is acquired.
摘要翻译： 公开了一种离子成像方法，包括扫描样本并以第一空间分辨率获取与第一像素位置相关的第一质谱数据，并确定第一质谱数据是否满足条件。 如果确定第一质谱数据确实满足条件，则存储，记录或优先化第一质谱数据。 如果确定第一质谱数据不满足条件，则第一质谱数据被丢弃或降级。 样本的扫描然后以第一空间分辨率继续进行，并且获取与另外的像素位置相关的进一步的质谱数据。
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公开(公告)号：US11133169B2
公开(公告)日：2021-09-28
申请号：US16306821
申请日：2017-06-05
申请人： MICROMASS UK LIMITED
发明人： Emrys Jones , Richard Chapman , Steven Pringle
摘要： Apparatus is disclosed comprising a first ion source (210) arranged and adapted to emit a spray of charged droplets (211) and a detector or sensor (203) arranged and adapted automatically to detect, sense or determine one or more first parameters or properties of the spray of charged droplets (211) as the spray of charged droplets (211) impacts upon a surface of the detector or sensor 203. The apparatus further comprises a control system (204) arranged and adapted to adjust, correct and/or optimise one or more second parameters or properties of the spray of charged droplets (211) based on the one or more first parameters or properties of the spray of charged droplets (211) detected, sensed or determined by the detector or sensor (203).
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公开(公告)号：US20190304768A1
公开(公告)日：2019-10-03
申请号：US16306809
申请日：2017-06-05
申请人： MICROMASS UK LIMITED
摘要： A method of analysing a sample is disclosed that comprises surveying a sample in a first mode of operation by directing a spray of charged droplets onto the sample, determining one or more regions of interest in the sample, and analysing the one or more regions of interest in a second different mode of operation by directing a spray of charged droplets onto the sample. The spot size of the spray of charged droplets at a point of impact with the sample may be varied.
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公开(公告)号：US20190198307A1
公开(公告)日：2019-06-27
申请号：US16306821
申请日：2017-06-05
申请人： MICROMASS UK LIMITED
发明人： Emrys Jones , Richard Chapman , Steven PRINGLE
CPC分类号： H01J49/142 , H01J49/0004 , H01J49/0009 , H01J49/0031 , H01J49/165
摘要： Apparatus is disclosed comprising a first ion source (210) arranged and adapted to emit a spray of charged droplets (211) and a detector or sensor (203) arranged and adapted automatically to detect, sense or determine one or more first parameters or properties of the spray of charged droplets (211) as the spray of charged droplets (211) impacts upon a surface of the detector or sensor 203. The apparatus further comprises a control system (204) arranged and adapted to adjust, correct and/or optimise one or more second parameters or properties of the spray of charged droplets (211) based on the one or more first parameters or properties of the spray of charged droplets (211) detected, sensed or determined by the detector or sensor (203).
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公开(公告)号：US09484192B2
公开(公告)日：2016-11-01
申请号：US14776036
申请日：2014-03-14
申请人： Micromass UK Limited
IPC分类号： H01J49/00
CPC分类号： H01J49/0004 , H01J49/0031 , H01J49/0036
摘要： A method of ion imaging is disclosed comprising scanning a sample and acquiring first mass spectral data related to a first pixel location at a first spatial resolution and determining whether or not the first mass spectral data satisfies a condition. If it is determined that the first mass spectral data does satisfy the condition then the first mass spectral data is stored, recorded or prioritized. If it is determined that the first mass spectral data does not satisfy the condition then the first mass spectral data is discarded or downgraded. Scanning of the sample then continues at the first spatial resolution and further mass spectral data related to further pixel locations is acquired.
摘要翻译： 公开了一种离子成像方法，包括扫描样品并以第一空间分辨率获取与第一像素位置相关的第一质谱数据，并确定第一质谱数据是否满足条件。 如果确定第一质谱数据确实满足条件，则存储，记录或优先化第一质谱数据。 如果确定第一质谱数据不满足条件，则第一质谱数据被丢弃或降级。 样本的扫描然后以第一空间分辨率继续进行，并且获取与另外的像素位置相关的进一步的质谱数据。
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公开(公告)号：US09390896B2
公开(公告)日：2016-07-12
申请号：US14776175
申请日：2014-03-14
申请人： Micromass UK Limited
CPC分类号： H01J49/0004 , H01J49/164
摘要： A method of ion imaging is disclosed comprising scanning a sample at a first resolution and acquiring first mass spectral data related to a first pixel location. A determination is then made as to whether or not the first mass spectral data satisfies a condition, wherein if it is determined that the first mass spectral data does satisfy the condition then the method further comprises: (i) switching to acquire second mass spectral data related to a second pixel location which is substantially adjacent to the first pixel location so that the second mass spectral data is acquired at a second resolution which is higher than the first resolution; and (ii) determining whether or not the second mass spectral data satisfies the condition, wherein if it is determined that the second mass spectral data does satisfy the condition then the method further comprises acquiring third mass spectral data related to a third pixel location which is substantially adjacent to the first or second pixel locations so that the third mass spectral is acquired at the second resolution and wherein if it is determined that the second or third mass spectral data does not satisfy the condition then the method further comprises switching back to scanning the sample at the first resolution.
摘要翻译： 公开了一种离子成像方法，包括以第一分辨率扫描样品并获取与第一像素位置相关的第一质谱数据。 然后确定第一质谱数据是否满足条件，其中如果确定第一质谱数据确实满足条件，则该方法还包括：（i）切换以获取第二质谱数据 涉及与第一像素位置基本相邻的第二像素位置，使得以高于第一分辨率的第二分辨率获取第二质谱数据; 以及（ii）确定所述第二质谱数据是否满足所述条件，其中如果确定所述第二质谱数据确实满足所述条件，则所述方法还包括获取与第三像素位置有关的第三质谱数据，所述第三质谱数据是 基本上与第一或第二像素位置相邻，使得以第二分辨率获取第三质谱，并且其中如果确定第二或第三质谱数据不满足条件，则该方法还包括切换回扫描 以第一分辨率进行抽样。
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9.发明申请MASS SPECTROMETER, CONTROL SYSTEM AND METHODS OF OPERATING AND ASSEMBLING A MASS SPECTROMETER 有权质谱仪，控制系统和操作和组装质谱仪的方法公开(公告)号：US20150076338A1
公开(公告)日：2015-03-19
申请号：US14306269
申请日：2014-06-17
申请人： MICROMASS UK LIMITED
发明人： Phillip Edward Young , Paul Doorbar , Peter G. Spreadbury , Richard Newton , Alan McKinnon , Richard B. Moulds , Richard Chapman , Anthony J. Gilbert
IPC分类号： H01J49/02
CPC分类号： H01J49/022 , H01J49/0027 , Y10T29/49117
摘要： A mass spectrometer and methods for controlling a mass spectrometer are provided. In an exemplary embodiment, the mass spectrometer includes a plurality of discrete functional modules, each operable to perform a predetermined function of the mass spectrometer, wherein the modules are individually addressable and connected in a network. The mass spectrometer can also include a scheduler operable to introduce discrete packets of instructions to the network at predetermined times to instruct at least one module to perform a predetermined operation.
摘要翻译： 提供质谱仪和控制质谱仪的方法。 在示例性实施例中，质谱仪包括多个离散功能模块，每个功能模块可操作以执行质谱仪的预定功能，其中模块可单独寻址并在网络中连接。 质谱仪还可以包括调度器，其可操作以在预定时间将离散指令分组引入网络，以指示至少一个模块执行预定操作。
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公开(公告)号：US20220037140A1
公开(公告)日：2022-02-03
申请号：US17277003
申请日：2019-09-17
申请人： Micromass UK Limited
IPC分类号： H01J49/16 , G01N1/30 , G01N33/92 , G01N33/68 , H01J49/00 , G06T7/00 , H01J49/04 , G06N20/00 , G06T7/11 , G01N1/06 , G01N27/623
摘要： Disclosed herein is a method of analysing a tissue sample. The method comprises identifying one or more regions of interest within the tissue sample based on a tissue stain that has been applied to the tissue sample. Analyte material is then generated from the one or more regions of interest identified based on the tissue stain using a direct surface sampling probe (10), which analyte material is then received at a sampling inlet (30) and passed towards a mass and/or ion mobility spectrometer (50) for analysis.
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