公开(公告)号：US06716196B2

公开(公告)日：2004-04-06

申请号：US09797483

申请日：2001-02-28

Applicant: Michael D. Lesh ,  Thomas F. Kordis ,  Stuart D. Edwards

Inventor： Michael D. Lesh ,  Thomas F. Kordis ,  Stuart D. Edwards

IPC: A61M5178

CPC classification number: A61M25/0136 ,  A61B17/22 ,  A61B2017/00243 ,  A61B2017/22082 ,  A61B2017/3488 ,  A61B2018/00273 ,  A61B2018/00815 ,  A61B2018/1425 ,  A61B2018/1435 ,  A61B2090/3784 ,  A61M25/0084 ,  A61M25/0133 ,  A61M25/0147 ,  A61N7/02

Abstract: This is a method and an apparatus for the introduction of therapeutic compounds into tissue, particularly cardiac tissue. The apparatus includes a catheter having an elongated flexible body and a tissue infusion apparatus including a hollow infusion needle configured to secure the needle into the tissue when the needle is at least partially inserted into the tissue to help prevent inadvertent removal of the needle from the tissue. This permits the selected therapeutic compound to be delivered to a specific site. The catheter may also include a visualization assembly including a transducer at the distal end of the body.

Abstract translation: 这是用于将治疗化合物引入组织，特别是心脏组织的方法和装置。 所述装置包括具有细长柔性体的导管和包括中空输液针的组织浸液装置，所述中空灌注针构造成当针至少部分插入组织中时将针固定到组织中，以帮助防止针头从组织中无意中移除 。 这允许将所选择的治疗化合物递送到特定部位。 导管还可以包括可视化组件，其包括在身体的远端处的换能器。

公开(公告)号：US5871443A

公开(公告)日：1999-02-16

申请号：US747811

申请日：1996-11-14

Applicant: Stuart D. Edwards ,  Thomas F. Kordis ,  David K. Swanson

Inventor： Stuart D. Edwards ,  Thomas F. Kordis ,  David K. Swanson

IPC: A61B5/042 ,  A61B18/14 ,  A61B18/18 ,  A61L29/08 ,  A61L29/14 ,  A61L31/10 ,  A61L31/14 ,  A61N1/05 ,  A61B5/04

CPC classification number: A61B5/6856 ,  A61B5/0422 ,  A61B5/6852 ,  A61B5/6853 ,  A61B5/6858 ,  A61B5/6859 ,  A61L29/085 ,  A61L29/145 ,  A61L31/10 ,  A61L31/145 ,  A61N1/056 ,  A61B18/14 ,  A61B18/18 ,  A61B2562/0209 ,  A61B2562/043 ,  Y10T29/49002 ,  Y10T29/49117

Abstract: An electrode assembly for use in interventricular cardiac mapping includes one or more elongated splines each of which carries a plurality of spaced apart electrodes thereon. The body of each spline is formed of a plurality of alternating electrically conductive layers and the electrically non-conductive layers. A separate electrically conductive pathway is provided to connect each of the electrodes to a different one of the conductive layers. Each of the layers is electrically connected to an electrical signal processing device so that signals provided by each of the electrodes can be processed.

公开(公告)号：US6052607A

公开(公告)日：2000-04-18

申请号：US34553

申请日：1998-03-03

Applicant: Stuart D. Edwards ,  Thomas F. Kordis ,  David K. Swanson

Inventor： Stuart D. Edwards ,  Thomas F. Kordis ,  David K. Swanson

IPC: A61B5/042 ,  A61B18/14 ,  A61B18/18 ,  A61L29/08 ,  A61L29/14 ,  A61L31/10 ,  A61L31/14 ,  A61N1/05 ,  A61B5/0408

CPC classification number: A61B5/6856 ,  A61B5/0422 ,  A61B5/6852 ,  A61B5/6853 ,  A61B5/6858 ,  A61B5/6859 ,  A61L29/085 ,  A61L29/145 ,  A61L31/10 ,  A61L31/145 ,  A61N1/056 ,  A61B18/14 ,  A61B18/18 ,  A61B2562/0209 ,  A61B2562/043 ,  Y10T29/49002 ,  Y10T29/49117

Abstract: An electrode assembly for use in interventricular cardiac mapping includes one or more elongated splines each of which carries a plurality of spaced apart electrodes thereon. The body of each spline is formed of a plurality of alternating electrically conductive layers and the electrically non-conductive layers. A separate electrically conductive pathway is provided to connect each of the electrodes to a different one of the conductive layers. Each of the layers is electrically connected to an electrical signal processing device so that signals provided by each of the electrodes can be processed.

Abstract translation: 用于室间心脏映射的电极组件包括一个或多个细长花键，每个细长花键在其上承载多个间隔开的电极。 每个花键的主体由多个交替导电层和非导电层形成。 提供单独的导电路径以将每个电极连接到不同的一个导电层。 每个层电连接到电信号处理装置，使得可以处理由每个电极提供的信号。

公开(公告)号：US5509419A

公开(公告)日：1996-04-23

申请号：US168476

申请日：1993-12-16

Applicant: Stuart D. Edwards ,  Thomas F. Kordis ,  David K. Swanson

Inventor： Stuart D. Edwards ,  Thomas F. Kordis ,  David K. Swanson

IPC: A61B5/042 ,  A61B18/14 ,  A61B18/18 ,  A61L29/08 ,  A61L29/14 ,  A61L31/10 ,  A61L31/14 ,  A61N1/05 ,  A61N5/02

CPC classification number: A61B5/6856 ,  A61B5/0422 ,  A61B5/6852 ,  A61B5/6853 ,  A61B5/6858 ,  A61B5/6859 ,  A61L29/085 ,  A61L29/145 ,  A61L31/10 ,  A61L31/145 ,  A61N1/056 ,  A61B18/14 ,  A61B18/18 ,  A61B2562/0209 ,  A61B2562/043 ,  Y10T29/49002 ,  Y10T29/49117

Abstract: An electrode assembly for use in interventricular cardiac mapping includes one or more elongated splines each of which carries a plurality of spaced apart electrodes thereon. The body of each spline is formed of a plurality of alternating electrically conductive layers and the electrically non-conductive layers. A separate electrically conductive pathway is provided to connect each of the electrodes to a different one of the conductive layers. Each of the layers is electrically connected to an electrical signal processing device so that signals provided by each of the electrodes can he processed.

Abstract translation: 用于室间心脏映射的电极组件包括一个或多个细长花键，每个细长花键在其上承载多个间隔开的电极。 每个花键的主体由多个交替导电层和非导电层形成。 提供单独的导电路径以将每个电极连接到不同的一个导电层。 每个层电连接到电信号处理装置，使得可以处理由每个电极提供的信号。

公开(公告)号：US5471982A

公开(公告)日：1995-12-05

申请号：US951728

申请日：1992-09-29

Applicant: Stuart D. Edwards ,  Jerome Jackson ,  Ingemar H. Lundquist ,  Thomas F. Kordis ,  Alan L. Kaganov

Inventor： Stuart D. Edwards ,  Jerome Jackson ,  Ingemar H. Lundquist ,  Thomas F. Kordis ,  Alan L. Kaganov

IPC: A61B5/042 ,  A61B18/14 ,  A61N1/06 ,  A61B5/0402

CPC classification number: A61B5/6856 ,  A61B18/1492 ,  A61B5/0422 ,  A61B5/6853 ,  A61B5/6858 ,  A61B5/6859 ,  A61N1/06 ,  A61B2017/22038 ,  A61B2018/00083 ,  A61B2018/00148 ,  A61B2018/0016 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00357 ,  A61B2018/00839 ,  A61B2018/1861 ,  A61B2562/0209 ,  A61B2562/043

Abstract: An improved probe for cardiac diagnosis and/or treatment includes a control handle and a catheter for insertion into the heart. The catheter has a distal end, a proximal end and at least one lumen connecting said distal and proximal ends. It also includes a flexible inner tube and an outer sheath enveloping said tube. At least one measuring electrode or ablation device is attached to the distal end of the tube. The outer sheath and the inner tube are rotatable relative to each other so that the electrode or device can be rotated within the heart without rotating the outer sheath. The sheath is also axially movable relative to the tube to selectively enclose or expose the electrode or device for use.

Abstract translation: 用于心脏诊断和/或治疗的改进探针包括控制手柄和用于插入心脏的导管。 导管具有远端，近端和连接所述远端和近端的至少一个腔。 它还包括柔性内管和包封所述管的外护套。 至少一个测量电极或消融装置附接到管的远端。 外鞘和内管可相对于彼此旋转，使得电极或装置可以在心脏内旋转而不旋转外护套。 鞘也可以相对于管轴向移动，以选择性地包围或暴露电极或装置以供使用。

公开(公告)号：US5313943A

公开(公告)日：1994-05-24

申请号：US951739

申请日：1992-09-25

Applicant: Russell A. Houser ,  Stuart D. Edwards ,  Thomas F. Kordis

Inventor： Russell A. Houser ,  Stuart D. Edwards ,  Thomas F. Kordis

IPC: A61B5/042 ,  A61B18/14 ,  A61N1/05 ,  A61B17/36

CPC classification number: A61B5/6852 ,  A61B18/1492 ,  A61B5/0422 ,  A61B5/6853 ,  A61B5/6858 ,  A61B5/6859 ,  A61N1/056 ,  A61B2018/0016 ,  A61B2018/00214 ,  A61B2018/00267 ,  A61B2018/00357 ,  A61B2018/00577 ,  A61B2018/00839 ,  A61B2018/0091 ,  A61B2018/1861 ,  A61B2218/002 ,  A61B2562/0209 ,  A61B2562/043

Abstract: A system and method for cardiac diagnosis and treatment inserts the distal end of a catheter into a heart chamber. The distal end of the catheter supports at least one electrode. The catheter has a fluid flow conduit extending through it. The conduit has a valve that prevents fluid flow from the heart chamber into the conduit in response to in vivo pressure generated during heart systole and diastole. The valve permits fluid flow from the conduit into the heart at a pressure above the in vivo pressure. In use, the catheter locates the electrode in contact with a portion of the endocardium, and fluid is conducted from an external source through the conduit at a pressure above the in vivo pressure to flush the area surrounding the electrode.

Abstract translation: 用于心脏诊断和治疗的系统和方法将导管的远端插入心室。 导管的远端支撑至少一个电极。 导管具有延伸穿过其的流体流动管道。 导管具有一个阀，其能够响应心脏收缩期和舒张期期间产生的体内压力，防止流体从心室流入导管。 阀允许流体在高于体内压力的压力下从导管流入心脏。 在使用中，导管将电极定位成与心内膜的一部分接触，并且流体在高于体内压力的压力下从外部源通过导管传导以冲洗电极周围的区域。

公开(公告)号：US6163716A

公开(公告)日：2000-12-19

申请号：US433604

申请日：1999-11-02

Applicant: Stuart D. Edwards ,  Thomas F. Kordis ,  David K. Swanson

Inventor： Stuart D. Edwards ,  Thomas F. Kordis ,  David K. Swanson

IPC: A61B5/042 ,  A61B18/14 ,  A61B18/18 ,  A61L29/08 ,  A61L29/14 ,  A61L31/10 ,  A61L31/14 ,  A61N1/05 ,  A61B5/0402

CPC classification number: A61B5/6856 ,  A61B5/0422 ,  A61B5/6852 ,  A61B5/6853 ,  A61B5/6858 ,  A61B5/6859 ,  A61B18/14 ,  A61B18/18 ,  A61B2562/0209 ,  A61B2562/043 ,  A61L29/085 ,  A61L29/145 ,  A61L31/10 ,  A61L31/145 ,  A61N1/056 ,  Y10T29/49002 ,  Y10T29/49117 ,  C08L1/02

Abstract: An electrode assembly for use in interventricular cardiac mapping includes one or more elongated splines each of which carries a plurality of spaced apart electrodes thereon. The body of each spline is formed of a plurality of alternating electrically conductive layers and the electrically non-conductive layers. A separate electrically conductive pathway is provided to connect each of the electrodes to a different one of the conductive layers. Each of the layers is electrically connnected to an electrical signal processing device so that signals provided by each of the electrodes can be processed.

Abstract translation: 用于室间心脏映射的电极组件包括一个或多个细长花键，每个细长花键在其上承载多个间隔开的电极。 每个花键的主体由多个交替导电层和非导电层形成。 提供单独的导电路径以将每个电极连接到不同的一个导电层。 每个层电连接到电信号处理装置，使得可以处理由每个电极提供的信号。

公开(公告)号：US5549108A

公开(公告)日：1996-08-27

申请号：US252060

申请日：1994-06-01

Applicant: Stuart D. Edwards ,  Thomas F. Kordis ,  David K. Swanson

Inventor： Stuart D. Edwards ,  Thomas F. Kordis ,  David K. Swanson

IPC: A61B5/042 ,  A61N1/06 ,  A61B5/0402 ,  A61N1/05

CPC classification number: A61B5/6856 ,  A61B5/0422 ,  A61B5/6853 ,  A61B5/6858 ,  A61B5/6859 ,  A61N1/06 ,  A61B2562/0209 ,  A61B2562/043

Abstract: A cardiac diagnosis and treatment system comprises a support carrying at least two electrodes. A conductor is associated with the support for selectively directing electrical signals to and from each electrode. The conductor includes a first buss for delivering power from an external power source, a second buss for transmitting electrode signals to an external signal processor, and a third buss for receiving control signals from an external signal source to multiplex the electrode signals from the electrodes through the second buss. A conduction line conducts power, control signals, and electrode signals from the external sources to the conductor.

Abstract translation: 心脏诊断和治疗系统包括承载至少两个电极的支撑件。 导体与用于选择性地将电信号导向每个电极和从每个电极引导的支撑件相关联。 导体包括用于从外部电源传递电力的第一总线，用于将电极信号传输到外部信号处理器的第二总线，以及用于从外部信号源接收控制信号的第三总线，以将来自电极的电极信号多路复用 第二个总线 导线将电源，控制信号和电极信号从外部源传导到导体。

公开(公告)号：US5309910A

公开(公告)日：1994-05-10

申请号：US951157

申请日：1992-09-25

Applicant: Stuart D. Edwards ,  Thomas F. Kordis ,  David K. Swanson

Inventor： Stuart D. Edwards ,  Thomas F. Kordis ,  David K. Swanson

IPC: A61B5/042 ,  A61B18/14 ,  A61B18/18 ,  A61L29/08 ,  A61L29/14 ,  A61L31/10 ,  A61L31/14 ,  A61N1/05

CPC classification number: A61B5/6856 ,  A61B5/0422 ,  A61B5/6852 ,  A61B5/6853 ,  A61B5/6858 ,  A61B5/6859 ,  A61L29/085 ,  A61L29/145 ,  A61L31/10 ,  A61L31/145 ,  A61N1/056 ,  A61B18/14 ,  A61B18/18 ,  A61B2562/0209 ,  A61B2562/043 ,  Y10T29/49002 ,  Y10T29/49117

Abstract: An electrode assembly for use in interventricular cardiac mapping includes one or more elongated splines each of which carries a plurality of spaced apart electrodes thereon. The body of each spline is formed of a plurality of alternating electrically conductive layers and the electrically non-conductive layers. A separate electrically conductive pathway is provided to connect each of the electrodes to a different one of the conductive layers. Each of the layers is electrically connected to an electrical signal processing device so that signals provided by each of the electrodes can be processed.

Abstract translation: 用于室间心脏映射的电极组件包括一个或多个细长花键，每个细长花键在其上承载多个间隔开的电极。 每个花键的主体由多个交替导电层和非导电层形成。 提供单独的导电路径以将每个电极连接到不同的一个导电层。 每个层电连接到电信号处理装置，使得可以处理由每个电极提供的信号。

公开(公告)号：US5921982A

公开(公告)日：1999-07-13

申请号：US846739

申请日：1997-04-30

Applicant: Michael D. Lesh ,  Stuart D. Edwards

Inventor： Michael D. Lesh ,  Stuart D. Edwards

IPC: A61B18/14 ,  A61B17/36

CPC classification number: A61B18/1492 ,  A61B2017/003 ,  A61B2018/0016 ,  A61B2018/00214 ,  A61B2018/00273 ,  A61B2018/00815 ,  A61B2018/00839 ,  A61B2018/1425 ,  A61B2018/1435 ,  A61B2090/3782 ,  A61N7/02

Abstract: A medical probe device for contacting tissue within the body a catheter tube having a control end and a probe end. The probe end includes a housing having a port. An element is located within the housing that is movable between a first position confined within the housing and a second position extending through the port outside the housing. The element has a distal tip adapted to penetrate a tissue region during movement between the first and second position. The element comprises an electrode for emitting electromagnetic radio frequency energy into the tissue region, or cannula with an interior lumen for conveying fluid to and from the tissue region, or a sensor for sensing temperature conditions in the tissue region.

Abstract translation: 一种医疗探针装置，用于使身体内的组织具有具有控制端和探针端的导管。 探针端部包括具有端口的壳体。 元件位于壳体内，其可在限制在壳体内的第一位置和延伸穿过壳体外部的端口的第二位置之间移动。 元件具有适于在第一和第二位置之间移动期间穿透组织区域的远侧末端。 该元件包括用于将电磁射频能量发射到组织区域中的电极，或具有用于向组织区域输送流体的内腔的插管或用于感测组织区域中的温度条件的传感器。