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    Means and Methods for Preventing and/or Treating Caries
    3.
    发明申请
    Means and Methods for Preventing and/or Treating Caries 有权
    预防和/或治疗龋齿的方法和方法

    公开(公告)号：US20080193427A1

    公开(公告)日：2008-08-14

    申请号：US11662347

    申请日：2005-09-09

    申请人： Bruno Kaesler ,  Rolf Knoll ,  Mewes Boettner ,  Eckhard Budde ,  Christine Lang ,  Martin Ryser ,  Markus Veen

    发明人： Bruno Kaesler ,  Rolf Knoll ,  Mewes Boettner ,  Eckhard Budde ,  Christine Lang ,  Martin Ryser ,  Markus Veen

    IPC分类号： A61K35/74 ,  C12N1/20 ,  A61Q11/00 ,  A61P43/00

    CPC分类号： A61K8/99 ,  A23G3/366 ,  A23G4/123 ,  A23K50/10 ,  A23K50/30 ,  A23K50/40 ,  A23K50/50 ,  A23K50/70 ,  A23K50/75 ,  A23K50/80 ,  A23L7/10 ,  A23L33/135 ,  A23V2002/00 ,  A23Y2220/63 ,  A23Y2220/73 ,  A23Y2240/49 ,  A61K8/0216 ,  A61K8/042 ,  A61K8/60 ,  A61K35/747 ,  A61Q11/00 ,  C12N1/20 ,  C12R1/225 ,  A23V2200/312 ,  A23V2200/3204

    摘要： The present invention relates to a microorganism belonging to the group of lactic acid bacteria characterized in that it is capable of specifically binding to Streptococcus mutans, wherein the specific binding is (i) resistant to heat treatment; and/or (ii) resistant to protease treatment; and/or (iii) calcium-dependent; and/or (iv) formed within a pH range between 4.5 and 8.5; and/or (v) formed in the presence of saliva. Preferably, the specific binding can be assayed as follows: (a) growing said microorganism to stationary phase; (b) mixing said microorganism with Streptococcus mutans which has been grown to stationary phase; (c) incubating the mixture obtained in step (b) under conditions allowing the formation of aggregates of said microorganism and Streptococcus mutans and (d) detecting aggregates by the occurrence of a pellet. Another aspect of the present invention is an analog or fragment of said microorganism which is thermally inactivated or lyophilized, wherein said analog or fragment retains the capability of specifically binding to Streptococcus mutans. In addition, the present invention encompasses compositions and additives for food, feed or drinks comprising the microorganism belonging to the group of lactic acid bacteria which specifically bind to Streptococcus mutans or an analog or fragment thereof. Moreover, uses of said microorganism or said analog or fragment thereof for the preparation of an anticariogenic or pharmaceutical composition or anticariogenic food or feedstuff as well as methods for producing said compositions or food or feedstuff are provided by the present invention.

    摘要翻译： 本发明涉及属于该乳酸菌群的微生物，其特征在于能够特异性结合变形链球菌，其特异性结合是（i）耐热处理; 和/或（ii）抗蛋白酶处理; 和/或（iii）钙依赖性; 和/或（iv）在4.5至8.5之间的pH范围内形成; 和/或（v）在唾液存在下形成。 优选地，可以如下测定特异性结合：（a）将所述微生物生长至固定相; （b）将所述微生物与已经生长至固定相的变形链球菌混合; （c）在允许形成所述微生物和变形链球菌的聚集体的条件下培养步骤（b）中获得的混合物，和（d）通过颗粒的发生检测聚集体。 本发明的另一方面是所述微生物的类似物或片段，其被热灭活或冻干，其中所述类似物或片段保留特异性结合变形链球菌的能力。 此外，本发明包括用于食品，饲料或饮料的组合物和添加剂，其包含特异性结合变形链球菌的乳酸菌群的微生物或其类似物或片段。 此外，本发明提供了所述微生物或其所述类似物或其片段用于制备抗焦虑药物或药物组合物或抗癌食品或饲料的用途，以及用于生产所述组合物或食物或饲料的方法。

    Microorganism of the genus Lactobacillus capable of binding to S. mutans and compositions comprising the same
    4.
    发明授权
    Microorganism of the genus Lactobacillus capable of binding to S. mutans and compositions comprising the same 有权
    能够结合变形链球菌的乳杆菌属的微生物和包含其的组合物

    公开(公告)号：US08192978B2

    公开(公告)日：2012-06-05

    申请号：US11662347

    申请日：2005-09-09

    申请人： Bruno Kaesler ,  Rolf Knöll ,  Mewes Boettner ,  Eckhard Budde ,  Christine Lang ,  Martin Ryser ,  Markus Veen

    发明人： Bruno Kaesler ,  Rolf Knöll ,  Mewes Boettner ,  Eckhard Budde ,  Christine Lang ,  Martin Ryser ,  Markus Veen

    IPC分类号： C12N1/20

    CPC分类号： A61K8/99 ,  A23G3/366 ,  A23G4/123 ,  A23K50/10 ,  A23K50/30 ,  A23K50/40 ,  A23K50/50 ,  A23K50/70 ,  A23K50/75 ,  A23K50/80 ,  A23L7/10 ,  A23L33/135 ,  A23V2002/00 ,  A23Y2220/63 ,  A23Y2220/73 ,  A23Y2240/49 ,  A61K8/0216 ,  A61K8/042 ,  A61K8/60 ,  A61K35/747 ,  A61Q11/00 ,  C12N1/20 ,  C12R1/225 ,  A23V2200/312 ,  A23V2200/3204

    摘要： The present invention relates to a microorganism belonging to the group of lactic acid bacteria characterized in that it is capable of specifically binding to Streptococcus mutans, wherein the specific binding is (i) resistant to heat treatment; and/or (ii) resistant to protease treatment; and/or (iii) calcium-dependent; and/or (iv) formed within a pH range between 4.5 and 8.5; and/or (v) formed in the presence of saliva. Preferably, the specific binding can be assayed as follows: (a) growing said microorganism to stationary phase; (b) mixing said microorganism with Streptococcus mutans which has been grown to stationary phase; (c) incubating the mixture obtained in step (b) under conditions allowing the formation of aggregates of said microorganism and Streptococcus mutans and (d) detecting aggregates by the occurrence of a pellet. Another aspect of the present invention is an analog or fragment of said microorganism which is thermally inactivated or lyophilized, wherein said analog or fragment retains the capability of specifically binding to Streptococcus mutans. In addition, the present invention encompasses compositions and additives for food, feed or drinks comprising the microorganism belonging to the group of lactic acid bacteria which specifically bind to Streptococcus mutans or an analog or fragment thereof. Moreover, uses of said microorganism or said analog or fragment thereof for the preparation of an anticariogenic or pharmaceutical composition or anticariogenic food or feedstuff as well as methods for producing said compositions or food or feedstuff are provided by the present invention.

    摘要翻译： 本发明涉及属于该乳酸菌群的微生物，其特征在于能够特异性结合变形链球菌，其特异性结合是（i）耐热处理; 和/或（ii）抗蛋白酶处理; 和/或（iii）钙依赖性; 和/或（iv）在4.5至8.5之间的pH范围内形成; 和/或（v）在唾液存在下形成。 优选地，可以如下测定特异性结合：（a）将所述微生物生长至固定相; （b）将所述微生物与已经生长至固定相的变形链球菌混合; （c）在允许形成所述微生物和变形链球菌的聚集体的条件下培养步骤（b）中获得的混合物，和（d）通过颗粒的发生检测聚集体。 本发明的另一方面是所述微生物的类似物或片段，其被热灭活或冻干，其中所述类似物或片段保留特异性结合变形链球菌的能力。 此外，本发明包括用于食品，饲料或饮料的组合物和添加剂，其包含特异性结合变形链球菌的乳酸菌群的微生物或其类似物或片段。 此外，本发明提供了所述微生物或其所述类似物或其片段用于制备抗焦虑药物或药物组合物或抗癌食品或饲料的用途，以及用于生产所述组合物或食物或饲料的方法。