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公开(公告)号：US09695163B2
公开(公告)日：2017-07-04
申请号：US14910548
申请日：2014-08-04
发明人： Nigel Liverton , Douglas C. Beshore , Scott D. Kuduk , Yunfu Luo , Na Meng , Tingting Yu
IPC分类号： C07D417/14 , C07D417/04
CPC分类号： C07D417/14 , C07D417/04
摘要： The present invention is directed to thiazole compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the thiazole compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds. The present invention is also directed to uses of these pharmaceutical compositions in the prevention or treatment of such diseases in which orexin receptors are involved.
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公开(公告)号：US10017504B2
公开(公告)日：2018-07-10
申请号：US15523252
申请日：2015-10-27
发明人： Nigel Liverton , Scott D. Kuduk , Douglas Beshore , Yunfu Luo , Na Meng , Tingting Yu
IPC分类号： C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , A61K31/4525 , A61K31/4535 , A61K31/4545 , A61K31/454 , A61K31/506
CPC分类号： C07D413/14 , C07D413/04 , C07D417/04 , C07D417/14
摘要： The present invention is directed to piperidine isoxazole and isothiazole orexin compounds which are antagonists of orexin receptors. Such compounds are of the general structural formula I: wherein the variables are defined herein. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the prevention or treatment of such diseases in which orexin receptors are involved.
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公开(公告)号：US10308645B2
公开(公告)日：2019-06-04
申请号：US15523251
申请日：2015-09-27
发明人： Nigel Liverton , Scott D. Kuduk , Yunfu Luo , Na Meng , Tingting Yu
IPC分类号： C07D413/04 , C07D413/14 , C07D417/14 , C07D417/04
摘要： The present invention is directed to piperidine oxadiazole and thiadiazole orexin compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the prevention or treatment of such diseases in which orexin receptors are involved.
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公开(公告)号：US20180370973A1
公开(公告)日：2018-12-27
申请号：US15535315
申请日：2015-12-18
发明人： Scott D. Kuduk , Nigel Liverton , Douglas C. Beshore , Na Meng , Yunfu Luo
IPC分类号： C07D487/04 , C07D471/04 , C07D498/04
CPC分类号： C07D487/04 , A61K45/06 , C07D471/04 , C07D498/02 , C07D498/04
摘要： The present invention is directed to fused heteroaryl derivative compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds. The present invention is also directed to uses of these pharmaceutical compositions in the prevention or treatment of such diseases in which orexin receptors are involved.
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公开(公告)号：US10526336B2
公开(公告)日：2020-01-07
申请号：US15535315
申请日：2015-12-18
发明人： Scott D. Kuduk , Nigel Liverton , Douglas C. Beshore , Na Meng , Yunfu Luo
IPC分类号： A61K31/519 , A61K31/4545 , A61K31/4985 , C07D487/04 , A61K45/06 , C07D471/04 , C07D498/02 , C07D498/04
摘要： The present invention is directed to fused heteroaryl derivative compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds. The present invention is also directed to uses of these pharmaceutical compositions in the prevention or treatment of such diseases in which orexin receptors are involved.
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公开(公告)号：US10010539B2
公开(公告)日：2018-07-03
申请号：US15523256
申请日：2015-10-27
发明人： Nigel Liverton , Scott D. Kuduk , Douglas Beshore , Yunfu Luo , Na Meng
IPC分类号： C07D401/04 , C07D401/14 , C07D409/14 , C07D413/14 , C07D471/02 , A61K31/437 , A61K31/454 , A61K31/4545 , A61K31/445
CPC分类号： A61K31/445 , C07D401/04 , C07D401/14 , C07D409/14 , C07D413/14 , C07D471/04
摘要： The present invention is directed to pyrazole, triazole and tetrazole compounds which are antagonists of orexin receptors. Such compounds are of the general structural formula I: The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds. The present invention is also directed to uses of these pharmaceutical compositions in the prevention or treatment of such diseases in which orexin receptors are involved.
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公开(公告)号：US09828368B2
公开(公告)日：2017-11-28
申请号：US14910552
申请日：2014-08-04
发明人： Nigel Liverton , Douglas C. Beshore , Scott D. Kuduk , Yunfu Luo , Na Meng , Tingting Yu
IPC分类号： C07D417/14 , C07D417/04 , C07D413/14 , C07D413/04
CPC分类号： C07D413/14 , C07D413/04 , C07D417/14
摘要： The present invention is directed to oxazole compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the oxazole compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds. The present invention is also directed to uses of these pharmaceutical compositions in the prevention or treatment of such diseases in which orexin receptors are involved.
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