公开(公告)号：US20020160441A1

公开(公告)日：2002-10-31

申请号：US10128869

申请日：2002-04-24

Applicant: Merck & Co., Inc.

Inventor： Jennifer Nielsen-Kahn ,  Michael C. Justice ,  Dennis M. Schmatz ,  Ming-Jo Hsu ,  Theresa W. Ku

IPC: C12Q001/18 ,  C12N001/18 ,  C12N001/10

CPC classification number: C07K14/00 ,  C12Q1/025 ,  C12Q1/18

Abstract: Inhibition of protein elongation factor 2 provides a target for identifying potential antifungal and antiparasitic compounds. EF2 inhibitors are useful as therapeutic agents against fungal and parasitic infections.

Abstract translation: 蛋白质延伸因子2的抑制提供了鉴定潜在抗真菌和抗寄生虫化合物的靶标。 EF2抑制剂可用作抗真菌和寄生虫感染的治疗剂。