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公开(公告)号：US20230250057A1
公开(公告)日：2023-08-10
申请号：US18178062
申请日：2023-03-03
IPC分类号： C07D205/08 , A61P3/04 , A61K31/365
CPC分类号： C07D205/08 , A61P3/04 , A61K31/365
摘要： Provided herein are novel lipase inhibitors and methods for using the same to treat inflammation, multisystem organ failure, necrotic pancreatic acinar cell death, acute pancreatitis, sepsis (e.g., culture negative sepsis), burns, and acne. For example, provided herein are two novel lipase inhibitors useful in the methods described herein:
or a pharmaceutically acceptable salt thereof.-
公开(公告)号：US11339126B2
公开(公告)日：2022-05-24
申请号：US16629842
申请日：2018-07-12
IPC分类号： A61K31/365 , C07D205/08 , A61P3/04
摘要： Provided herein are novel lipase inhibitors and methods for using the same to treat inflammation, multisystem organ failure, necrotic pancreatic acinar cell death, acute pancreatitis, sepsis (e.g., culture negative sepsis), burns, and acne. For example, provided herein are two novel lipase inhibitors useful in the methods described herein: or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US20180319894A1
公开(公告)日：2018-11-08
申请号：US15773450
申请日：2016-11-02
发明人： Vijay P. Singh
IPC分类号： C07K16/40 , A61K31/365 , A61P1/18
CPC分类号： C07K16/40 , A61K31/337 , A61K31/365 , A61K31/536 , A61K2039/505 , A61P1/18 , C07K16/18 , C07K2317/76
摘要： This document provides materials and methods for treating pancreatitis (e.g., severe acute pancreatitis), a complication associated with pancreatitis (e.g., organ failure), and/or an acute inflammatory condition in a mammal (e.g., inflammation from a burn or trauma). For example, methods and materials for using one or more colipase inhibitors to treat a mammal having pancreatitis (e.g., acute pancreatitis) are provided.
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公开(公告)号：US09717626B2
公开(公告)日：2017-08-01
申请号：US13972123
申请日：2013-08-21
发明人： Vijay P. Singh
CPC分类号： A61F7/123 , A61B90/39 , A61F7/10 , A61M25/007 , A61M25/1002 , A61M25/1011 , A61M2025/0034
摘要： Materials and methods for producing localized hypothermia in a patient (e.g., for treatment of acute pancreatitis and pancreatic cancer).
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5.发明申请公开(公告)号：US20130338741A1
公开(公告)日：2013-12-19
申请号：US13972123
申请日：2013-08-21
发明人： Vijay P. Singh
IPC分类号： A61F7/12
CPC分类号： A61F7/123 , A61B90/39 , A61F7/10 , A61M25/007 , A61M25/1002 , A61M25/1011 , A61M2025/0034
摘要： Materials and methods for producing localized hypothermia in a patient (e.g., for treatment of acute pancreatitis and pancreatic cancer).
摘要翻译： 用于在患者中产生局部低温的材料和方法（例如，用于治疗急性胰腺炎和胰腺癌）。
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公开(公告)号：US11976040B2
公开(公告)日：2024-05-07
申请号：US18178062
申请日：2023-03-03
IPC分类号： A61K31/365 , A61P3/04 , C07D205/08
CPC分类号： C07D205/08 , A61K31/365 , A61P3/04
摘要： Provided herein are novel lipase inhibitors and methods for using the same to treat inflammation, multisystem organ failure, necrotic pancreatic acinar cell death, acute pancreatitis, sepsis (e.g., culture negative sepsis), burns, and acne. For example, provided herein are two novel lipase inhibitors useful in the methods described herein:
or a pharmaceutically acceptable salt thereof.-
公开(公告)号：US20210139421A1
公开(公告)日：2021-05-13
申请号：US16629842
申请日：2018-07-12
IPC分类号： C07D205/08 , A61P3/04
摘要： Provided herein are novel lipase inhibitors and methods for using the same to treat inflammation, multisystem organ failure, necrotic pancreatic acinar cell death, acute pancreatitis, sepsis (e.g., culture negative sepsis), burns, and acne. For example, provided herein are two novel lipase inhibitors useful in the methods described herein: or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US20210069013A1
公开(公告)日：2021-03-11
申请号：US17084669
申请日：2020-10-30
发明人： Vijay P. Singh
摘要： Materials and methods for producing localized hypothermia in a patient (e.g., for treatment of acute pancreatitis and pancreatic cancer).
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公开(公告)号：US20240343688A1
公开(公告)日：2024-10-17
申请号：US18637793
申请日：2024-04-17
IPC分类号： C07D205/08 , A61K31/365 , A61P3/04
CPC分类号： C07D205/08 , A61K31/365 , A61P3/04
摘要： Provided herein are novel lipase inhibitors and methods for using the same to treat inflammation, multisystem organ failure, necrotic pancreatic acinar cell death, acute pancreatitis, sepsis (e.g., culture negative sepsis), burns, and acne. For example, provided herein are two novel lipase inhibitors useful in the methods described herein:
or a pharmaceutically acceptable salt thereof.-
公开(公告)号：US11623915B2
公开(公告)日：2023-04-11
申请号：US17725281
申请日：2022-04-20
IPC分类号： A61K31/365 , C07D205/08 , A61P3/04
摘要： Provided herein are novel lipase inhibitors and methods for using the same to treat inflammation, multisystem organ failure, necrotic pancreatic acinar cell death, acute pancreatitis, sepsis (e.g., culture negative sepsis), burns, and acne. For example, provided herein are two novel lipase inhibitors useful in the methods described herein: or a pharmaceutically acceptable salt thereof.
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