公开(公告)号：US20240055154A1

公开(公告)日：2024-02-15

申请号：US18332326

申请日：2023-06-09

Applicant: Massachusetts Institute of Technology

Inventor： Juliette Marion ,  Polina Olegovna ANIKEEVA ,  Yoel FINK

IPC: H01B7/04 ,  H01B1/02 ,  H01B3/44 ,  D03D15/292 ,  D03D1/00 ,  D04B1/16 ,  D03D15/25 ,  D03D15/283 ,  D03D15/30

CPC classification number: H01B7/04 ,  H01B1/02 ,  H01B3/44 ,  D03D15/292 ,  D03D1/0088 ,  D04B1/16 ,  D03D15/25 ,  D03D15/283 ,  D03D15/30 ,  D10B2401/061 ,  D10B2321/02

Abstract: An elastic and conductive fiber includes a cladding with a channel and a conductor disposed therein. The cladding may be made of a thermoplastic elastomer. The conductive fiber includes an excess length of conductor disposed inside of the channel so that the conductive fiber can stretch without applying substantial strain to the conductor and without substantially changing the electrical resistance of the conductive fiber. The conductor inside of the channel may have a buckled shape or a helical shape.

公开(公告)号：US20250010095A1

公开(公告)日：2025-01-09

申请号：US18710934

申请日：2022-11-16

Applicant: Massachusetts Institute of Technology

Inventor： Polina Olegovna ANIKEEVA ,  Atharva Sahasrabudhe ,  Laura Rupprecht ,  Tural Khudiyev ,  Diego Bohorquez

IPC: A61N5/06

Abstract: Multifunctional microelectronics fiber probes can be chronically implanted in tissue of awake-behaving animals for understanding brain-viscera communication. These fiber probes can be made using thermal drawing to make hundreds of meters of flexible fiber that incorporates features such as light sources, electrodes, thermal sensors, and microfluidic channels in a multilayered configuration. The fiber mechanics can be tuned for two distinct device layouts: (1) higher-modulus, flexible brain fibers for implantation into deep-brain; and (2) soft, compliant gut fibers for implantation into the small intestine. Brain fibers can modulate the deep-brain mesolimbic reward pathway. Gut fibers can perform peripheral optogenetic stimulation of vagal afferents from the intestine to stimulate brain reward neurons. Brain and gut fibers can be connected to a control module, for example, with a coiled, stretchable interconnect that is more flexible and stretches more than even soft gut fibers, in dual-organ (gut-brain) implantation.

公开(公告)号：US20240347239A1

公开(公告)日：2024-10-17

申请号：US18635476

申请日：2024-04-15

Applicant: Massachusetts Institute of Technology

Inventor： Polina Olegovna ANIKEEVA ,  Ye Ji Kim ,  Florian Koehler

IPC: H01F1/00 ,  H01F1/06 ,  H01F1/24

CPC classification number: H01F1/0054 ,  H01F1/0063 ,  H01F1/061 ,  H01F1/063 ,  H01F1/24

Abstract: Anisotropic magnetothermal nanoparticles and methods for making the same are disclosed. The anisotropic magnetothermal nanoparticle may include a core and a shell. The core may include hexagonal nanodisc hematite (Fe2O3). The shell may include AxFe3-xO4, where A=Co, Mn, Ni, Fe, Zn, Mg, or Cu. The anisotropic magnetothermal nanoparticle may also include a polymer coating.

公开(公告)号：US20230359276A1

公开(公告)日：2023-11-09

申请号：US18314317

申请日：2023-05-09

Applicant: Massachusetts Institute of Technology

Inventor： Anthony Tabet ,  Polina Olegovna ANIKEEVA

IPC: A61B5/00 ,  G06F3/01

CPC classification number: G06F3/015 ,  A61B5/6868

Abstract: Solvent evaporation or entrapment-driven (SEED) integration is a rapid, robust, and modular approach to creating multifunctional fiber-based neural interfaces. SEED integration brings together electrical, optical, and microfluidic modalities within a co-polymer comprised of watersoluble poly(ethylene glycol) tethered to water-insoluble poly(urethane) (PU-PEG). The resulting neural interfaces can perform optogenetics and electrophysiology simultaneously. They can also be used to deliver cellular cargo with high viability. Upon exposure to water, PU-PEG cladding spontaneously forms a hydrogel, which, in addition to enabling integration of modalities, can harbor small molecules and nanomaterials that can be released into local tissue following implantation. For example, the hydrogel of a SEED-integrated neural interface can host a custom nanodroplet-forming block polymer for delivery of hydrophobic small molecules in vitro and in vivo. SEED integration widens the chemical toolbox and expands the capabilities of multifunctional neural interfaces.

公开(公告)号：US20230321431A1

公开(公告)日：2023-10-12

申请号：US18167128

申请日：2023-02-10

Applicant: Massachusetts Institute of Technology

Inventor： Polina Olegovna ANIKEEVA ,  Atharva Sahasrabudhe ,  Rajib Mondal

IPC: A61N1/05 ,  A61B5/257 ,  A61N5/06 ,  A61B5/01 ,  A61B5/00 ,  A61L31/02 ,  A61L31/06

CPC classification number: A61N1/0509 ,  A61B5/257 ,  A61N5/0603 ,  A61B5/01 ,  A61B5/4238 ,  A61N5/0622 ,  A61L31/022 ,  A61L31/06 ,  A61B2562/0261 ,  A61B2562/125 ,  A61N2005/0609

Abstract: A soft, stretchable, multifunctional bioelectronic interface can be used to monitor and/or modulate an entire organ, such as a stomach, heart, bladder, or spinal cord. The interface's softness translates to reduced mechanical mismatch with the tissue, and the interface's stretchability reduces interfacial stress with dynamically expanding and contracting organs. The electronics are stretchable thanks in part to liquid-metal conductors sealed within hollow channels of elastomeric fibers embedded in the interface. The liquid metal is largely strain-insensitive, non-toxic, and has a melting point of less than 37° C., so it remains liquid when implanted in a mammalian body. The liquid metal conductors connect microelectronic components, such as micro light-emitting diodes (μLEDs), electrodes, photodiodes, and temperature sensors, to a flexible printed circuit board (fPCB) at one end of the fiber. The interface may include other microelectronic components, such as piezoelectric strain sensors, that are also coupled to the fPCB.