公开(公告)号：US20230359276A1

公开(公告)日：2023-11-09

申请号：US18314317

申请日：2023-05-09

Applicant: Massachusetts Institute of Technology

Inventor： Anthony Tabet ,  Polina Olegovna ANIKEEVA

IPC: A61B5/00 ,  G06F3/01

CPC classification number: G06F3/015 ,  A61B5/6868

Abstract: Solvent evaporation or entrapment-driven (SEED) integration is a rapid, robust, and modular approach to creating multifunctional fiber-based neural interfaces. SEED integration brings together electrical, optical, and microfluidic modalities within a co-polymer comprised of watersoluble poly(ethylene glycol) tethered to water-insoluble poly(urethane) (PU-PEG). The resulting neural interfaces can perform optogenetics and electrophysiology simultaneously. They can also be used to deliver cellular cargo with high viability. Upon exposure to water, PU-PEG cladding spontaneously forms a hydrogel, which, in addition to enabling integration of modalities, can harbor small molecules and nanomaterials that can be released into local tissue following implantation. For example, the hydrogel of a SEED-integrated neural interface can host a custom nanodroplet-forming block polymer for delivery of hydrophobic small molecules in vitro and in vivo. SEED integration widens the chemical toolbox and expands the capabilities of multifunctional neural interfaces.