公开(公告)号：US20060089322A1

公开(公告)日：2006-04-27

申请号：US10513255

申请日：2003-05-01

申请人： Mark Vincent ,  Donald Koropatnick ,  Randall Berg

发明人： Mark Vincent ,  Donald Koropatnick ,  Randall Berg

IPC分类号： A61K48/00 ,  A61K31/7072 ,  A61K31/513 ,  C12Q1/68 ,  C07H21/04

CPC分类号： C12N15/1137 ,  A61K38/00 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/341 ,  C12N2310/346 ,  C12Y102/01002 ,  C12Y201/01045 ,  C12N2310/3525

摘要： The present invention provides antisense oligonucleotides useful for identifying drug targets for cancer therapies and for enhancing current cancer therapies. The oligonucleotides of the invention are complementary to thymidylate synthase mRNA and affect expression of at least one other gene. For the enhancement of cancer therapies, such antisense oligonucleotides can be used in conjunction with standard chemotherapeutic agents in order to target thymidylate synthase, as well as other appropriate targets. The antisense oligonucleotides and the methods of the invention constitute improved antisense therapies with application to a variety of cancers.

摘要翻译： 本发明提供了用于鉴定癌症疗法的药物靶标和用于增强目前的癌症疗法的反义寡核苷酸。 本发明的寡核苷酸与胸苷酸合酶mRNA互补并影响至少一种其他基因的表达。 为了增强癌症疗法，这种反义寡核苷酸可以与标准化学治疗剂结合使用，以靶向胸苷酸合酶以及其他合适的靶标。 反义寡核苷酸和本发明的方法构成了应用于多种癌症的改进的反义治疗。

公开(公告)号：US07468003B2

公开(公告)日：2008-12-23

申请号：US11401108

申请日：2006-04-10

申请人： Robert MacDermott ,  Gary Tremblay ,  Randall Berg

发明人： Robert MacDermott ,  Gary Tremblay ,  Randall Berg

IPC分类号： A63B69/36 ,  A61F2/54

CPC分类号： A63B69/36 ,  A61F2/588 ,  A63B21/4017 ,  A63B69/3608 ,  A63B71/0009 ,  A63B2102/32

摘要： A prosthetic device for golfing having an elongate resilient body with an axis, a first end, a second end and an exterior golf club support surface extending along the axis between the first end and the second end. Gripping members are positioned on opposed sides of the golf club support surface adjacent the first end. The gripping members are adapted to grip a golf club shaft and maintain the golf club shaft engaged with the golf club support surface. A coupling is provided at the first end which is adapted to be secured to a terminal device worn by the user. The coupling element may be either a male end or female end attached to the first end.

摘要翻译： 一种用于高尔夫球的假体装置，具有带有轴线的细长弹性体，第一端，第二端和在第一端和第二端之间沿轴线延伸的外部高尔夫球杆支撑表面。 夹持构件位于邻近第一端的高尔夫球杆支撑表面的相对侧上。 夹持构件适于夹持高尔夫球杆杆杆并且保持高尔夫球杆杆杆与高尔夫球杆支撑表面接合。 在第一端处设置有适于固定到用户佩戴的终端设备上的联接器。 联接元件可以是连接到第一端的阳端或阴端。

公开(公告)号：US20070105638A1

公开(公告)日：2007-05-10

申请号：US11401108

申请日：2006-04-10

申请人： Robert MacDermott ,  Gary Tremblay ,  Randall Berg

发明人： Robert MacDermott ,  Gary Tremblay ,  Randall Berg

IPC分类号： A63B69/36

CPC分类号： A63B69/36 ,  A61F2/588 ,  A63B21/4017 ,  A63B69/3608 ,  A63B71/0009 ,  A63B2102/32

摘要： A prosthetic device for golfing having an elongate resilient body with an axis, a first end, a second end and an exterior golf club support surface extending along the axis between the first end and the second end. Gripping members are positioned on opposed sides of the golf club support surface adjacent the first end. The gripping members are adapted to grip a golf club shaft and maintain the golf club shaft engaged with the golf club support surface. A coupling is provided at the first end which is adapted to be secured to a terminal device worn by the user. The coupling element may be either a male end or female end attached to the first end.

摘要翻译： 一种用于高尔夫球的假体装置，具有带有轴线的细长弹性体，第一端，第二端和在第一端和第二端之间沿轴线延伸的外部高尔夫球杆支撑表面。 夹持构件位于邻近第一端的高尔夫球杆支撑表面的相对侧上。 夹持构件适于夹持高尔夫球杆杆杆并且保持高尔夫球杆杆杆与高尔夫球杆支撑表面接合。 在第一端处设置有适于固定到用户佩戴的终端设备上的联接器。 联接元件可以是连接到第一端的阳端或阴端。