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公开(公告)号：US20100234311A1
公开(公告)日：2010-09-16
申请号：US12725156
申请日：2010-03-16
申请人： Mark T. Hamann , Mohamed Ali
发明人： Mark T. Hamann , Mohamed Ali
IPC分类号： A61K31/352 , C07D311/28 , C07D405/04 , A61P31/04 , A61K31/7048 , A01N43/16 , A01P1/00
CPC分类号： C07D407/14 , A01N43/16 , A01N2300/00
摘要： This present provides kaempferol-3-(2-E,3-Z-di-p-coumaroyl)-rhamnoside, kaempferol-3-(2-Z-3-E-di-p-coumaroyl)-rhamnoside, and kaempferol-3-(2,3-di-Z-p-coumaroyl)-rhamnoside compounds useful as a new class of anti-bacterial agents. These compounds are extracted from Platanus occidentalis. These compounds were found to exhibit anti-bacterial activity against methicillin resistant Staphylococcus aureus (MRSA).
摘要翻译： 本发明提供山奈酚-3-（2-E，3-Z-二对 - 香豆酰基） - 山梨糖苷，山奈酚-3-（2-Z-3-E-二对 - 香豆酰基） - 山梨糖苷和山奈酚 - 可用作新一类抗菌剂的3-（2,3-二 - Zp-香豆酰基） - 鼠李糖苷化合物。 这些化合物从西葫芦中提取。 发现这些化合物对耐甲氧西林金黄色葡萄球菌（MRSA）具有抗细菌活性。
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公开(公告)号：US08633166B2
公开(公告)日：2014-01-21
申请号：US12725156
申请日：2010-03-16
申请人： Mark T. Hamann , Mohamed Ali
发明人： Mark T. Hamann , Mohamed Ali
CPC分类号： C07D407/14 , A01N43/16 , A01N2300/00
摘要： This present provides kaempferol-3-(2-E,3-Z-di-p-coumaroyl)-rhamnoside, kaempferol-3-(2-Z-3-E-di-p-coumaroyl)-rhamnoside, and kaempferol-3-(2,3-di-Z-p-coumaroyl)-rhamnoside compounds useful as a new class of anti-bacterial agents. These compounds are extracted from Platanus occidentalis. These compounds were found to exhibit anti-bacterial activity against methicillin resistant Staphylococcus aureus (MRSA).
摘要翻译： 本发明提供山奈酚-3-（2-E，3-Z-二对 - 香豆酰基） - 山梨糖苷，山奈酚-3-（2-Z-3-E-二对 - 香豆酰基） - 山梨糖苷和山奈酚 - 可用作新一类抗菌剂的3-（2,3-二 - Zp-香豆酰基） - 鼠李糖苷化合物。 这些化合物从西葫芦中提取。 发现这些化合物对耐甲氧西林金黄色葡萄球菌（MRSA）具有抗细菌活性。
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公开(公告)号：US20220127280A1
公开(公告)日：2022-04-28
申请号：US17420668
申请日：2020-01-09
申请人： Mark T. Hamann
发明人： Mark T. Hamann
IPC分类号： C07D495/22 , A61P35/00
摘要： Aleutianamine represents the first in a new class of pyrroloiminoquinone alkaloids possessing a highly strained multi-bridged ring system, discovered from Latrunculia (Latrunculia) austini Samaai, Kelly & Gibbons, 2006 (class Demospongiae, order Poecilosclerida, family Latrunculiidae) recovered during a NOAA deep-water exploration of the Aleutian Islands. Aleutianamine exhibited potent and selective cytotoxicity toward solid tumor cell lines including pancreatic cancer (PANC-1) with an IC50 of 25 nM and colon cancer (H116) with IC50 of 1 μM.
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4.发明申请Method to Use Compositions Having Antidepressant Anxiolytic and Other Neurological Activity and Compositions of Matter 审中-公开使用具有抗抑郁敏感性和其他神经活性和组成的组合物的方法公开(公告)号：US20090093513A1
公开(公告)日：2009-04-09
申请号：US12248234
申请日：2008-10-09
IPC分类号： A61K31/4745 , A61K31/404 , A61K31/135 , A61P25/00
CPC分类号： A61K31/135 , A61K31/404 , A61K31/4745
摘要： The sponges were collected from a variety of locations in the Florida Keys and separated based on morphology and color. The samples were identified as three species, two of which are well known: V. rigida (Esper, 1794) (order Verongida, family Aplysinidae) and S. aurea (Hyatt, 1875) (order Dictyoceratida, family Thorectidae), and a third S. cerebriformis (Duchassaing & Michelotti, 1864), is less common and separated based on subtle differences of morphology and coloration, from the other two species. Several compounds were isolated and were evaluated in established animal models predictive of neurological related drug function, namely, the rodent FST and the chick anxiety-depression model.
摘要翻译： 从佛罗里达群岛的各种地点收集海绵，并根据形态和颜色进行分离。 样品被鉴定为三种，其中两种是众所周知的：其中两种是知名的：V. rigida（Esper，1794）（Veriantida，Aplysinidae）和S.Aurea（Hyatt，1875）（Dictyoceratida，Thorectidae） 基于形态学和着色的微妙差异，其他两个物种的脑血管病（Duchassaing＆Michelotti，1864）较不常见和分离。 分离出几种化合物，并在建立的动物模型中进行评估，预测神经相关药物功能，即啮齿动物FST和小鸡焦虑抑郁模型。
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5.发明授权Method to use compositions having antidepressant anxiolytic and other neurological activity and compositions of matter 有权使用具有抗抑郁药抗焦虑作用和其他神经活性物质组成的组合物的方法公开(公告)号：US08268856B2
公开(公告)日：2012-09-18
申请号：US13253958
申请日：2011-10-05
IPC分类号： A61K31/4375 , A61K31/4045 , A61K31/137 , C07D471/04 , A61P25/24 , A61P25/22
CPC分类号： A61K31/135 , A61K31/404 , A61K31/4745
摘要： The sponges were collected from a variety of locations in the Florida Keys and separated based on morphology and color. The samples were identified as three species, two of which are well known: V. rigida (Esper, 1794) (order Verongida, family Aplysinidae) and S. aurea (Hyatt, 1875) (order Dictyoceratida, family Thorectidae), and a third S. cerebriformis (Duchassaing & Michelotti, 1864), is less common and separated based on subtle differences of morphology and coloration, from the other two species. Several compounds were isolated and were evaluated in established animal models predictive of neurological related drug function, namely, the rodent FST and the chick anxiety-depression model.
摘要翻译： 从佛罗里达群岛的各种地点收集海绵，并根据形态和颜色进行分离。 样品被鉴定为三种，其中两种是众所周知的：其中两种是知名的：V. rigida（Esper，1794）（Veriantida，Aplysinidae）和S.Aurea（Hyatt，1875）（Dictyoceratida，Thorectidae） 基于形态学和着色的微妙差异，其他两个物种，脑血管病（Duchassaing＆Michelotti，1864）较不常见和分离。 分离出几种化合物，并在建立的动物模型中进行评估，预测神经相关药物功能，即啮齿动物FST和小鸡焦虑抑郁模型。
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6.发明申请METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS ACTIVE METABOLITES ISOLATED FROM LAURUS NOBILIS AND COMBINATIONS THEREOF 审中-公开耐甲氧西林金黄色葡萄球菌活性代谢物分离自LAURUS NOBILIS及其组合公开(公告)号：US20100273726A1
公开(公告)日：2010-10-28
申请号：US12767944
申请日：2010-04-27
申请人： Mark T. Hamann , Mohamed A. Ibrahim
发明人： Mark T. Hamann , Mohamed A. Ibrahim
IPC分类号： A61K31/7048 , C07H17/04 , A61P31/04
CPC分类号： A61K31/7048 , C07H17/07
摘要： This present provides kaempferol-3-(2-E,3-Z-di-p-coumaroyl)-rhamnoside, kaempferol-3-(2-Z-3-E-di-p-coumaroyl)-rhamnoside, and kaempferol-3-(2,3-di-Z-p-coumaroyl)-rhamnoside compounds useful as a new class of anti-bacterial agents. These compounds are extracted from Platanus occidentalis or Laurus nobilis. These compounds were found to exhibit anti-bacterial activity against methicillin resistant Staphylococcus aureus (MRSA).
摘要翻译： 本发明提供山奈酚-3-（2-E，3-Z-二对 - 香豆酰基） - 山梨糖苷，山奈酚-3-（2-Z-3-E-二对 - 香豆酰基） - 山梨糖苷和山奈酚 - 可用作新一类抗菌剂的3-（2,3-二 - Zp-香豆酰基） - 鼠李糖苷化合物。 这些化合物是从西洋番茄或金牛Laurus Nobilis提取的。 发现这些化合物对耐甲氧西林金黄色葡萄球菌（MRSA）具有抗细菌活性。
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公开(公告)号：US11325919B1
公开(公告)日：2022-05-10
申请号：US17420668
申请日：2020-01-09
申请人： Mark T. Hamann
发明人： Mark T. Hamann
IPC分类号： C07D495/22 , A61P35/00
摘要： Aleutianamine represents the first in a new class of pyrroloiminoquinone alkaloids possessing a highly strained multi-bridged ring system, discovered from Latrunculia (Latrunculia) austini Samaai, Kelly & Gibbons, 2006 (class Demospongiae, order Poecilosclerida, family Latrunculiidae) recovered during a NOAA deep-water exploration of the Aleutian Islands. Aleutianamine exhibited potent and selective cytotoxicity toward solid tumor cell lines including pancreatic cancer (PANC-1) with an IC50 of 25 nM and colon cancer (H116) with IC50 of 1 μM.
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8.发明申请METHOD TO USE COMPOSITIONS HAVING ANTIDEPRESSANT ANXIOLYTIC AND OTHER NEUROLOGICAL ACTIVITY AND COMPOSITIONS OF MATTER 有权使用具有抗肿瘤抗炎药和其他神经活性的组合物的方法和物质组合物公开(公告)号：US20120029010A1
公开(公告)日：2012-02-02
申请号：US13253958
申请日：2011-10-05
IPC分类号： A61K31/4375 , A61P25/22 , A61K31/137 , A61P25/24 , C07D471/04 , A61K31/4045
CPC分类号： A61K31/135 , A61K31/404 , A61K31/4745
摘要： The sponges were collected from a variety of locations in the Florida Keys and separated based on morphology and color. The samples were identified as three species, two of which are well known: V. rigida (Esper, 1794) (order Verongida, family Aplysinidae) and S. aurea (Hyatt, 1875) (order Dictyoceratida, family Thorectidae), and a third S. cerebriformis (Duchassaing & Michelotti, 1864), is less common and separated based on subtle differences of morphology and coloration, from the other two species. Several compounds were isolated and were evaluated in established animal models predictive of neurological related drug function, namely, the rodent FST and the chick anxiety-depression model.
摘要翻译： 从佛罗里达群岛的各种地点收集海绵，并根据形态和颜色进行分离。 样品被鉴定为三种，其中两种是众所周知的：其中两种是知名的：V. rigida（Esper，1794）（Veriantida，Aplysinidae）和S.Aurea（Hyatt，1875）（Dictyoceratida，Thorectidae） 基于形态学和着色的微妙差异，其他两个物种的脑血管病（Duchassaing＆Michelotti，1864）较不常见和分离。 分离出几种化合物，并在建立的动物模型中进行评估，预测神经相关药物功能，即啮齿动物FST和小鸡焦虑抑郁模型。
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公开(公告)号：US06900195B2
公开(公告)日：2005-05-31
申请号：US10362400
申请日：2001-08-29
申请人： Mark T. Hamann , Khalid El-Sayed
发明人： Mark T. Hamann , Khalid El-Sayed
IPC分类号： A61K31/475 , A61K31/33 , A61K31/437 , A61K35/56 , A61P31/04 , A61P31/12 , A61P31/18 , A61P31/20 , A61P31/22 , A61P33/02 , A61P33/06 , A01N43/00
CPC分类号： A61K31/33 , A61K31/437 , Y02A50/387 , Y02A50/409 , Y02A50/411 , Y02A50/414 , Y02A50/415 , Y02A50/481
摘要： A method of treating an infectious disease or condition in a subject in need of such treatment is disclosed. The method comprises administering to a subject an effective amount of a manzamine, manzamine derivative or analog or an optical isomer or racemate or tautomer thereof or a pharmaceutically acceptable salt thereof.
摘要翻译： 公开了治疗需要这种治疗的受试者的感染性疾病或病症的方法。 该方法包括向受试者施用有效量的胺，胺盐衍生物或类似物或其旋光异构体或外消旋物或其互变异构体或其药学上可接受的盐。
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