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公开(公告)号：US07329762B2
公开(公告)日：2008-02-12
申请号：US10559857
申请日：2004-06-08
IPC分类号： C07D207/00 , C07D405/00 , C07D295/00 , A01N43/36 , A61K31/40
CPC分类号： C07D401/12 , C07D207/20 , C07D209/48 , C07F9/572 , C07F9/65586
摘要： The present invention relates to phosphate ester prodrugs of dihydropyrrole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
摘要翻译： 本发明涉及二氢吡咯化合物的磷酸酯前体药物，其可用于治疗细胞增殖性疾病，用于治疗与KSP驱动蛋白活性相关的病症和用于抑制KSP驱动蛋白。 本发明还涉及包含这些化合物的组合物，以及使用它们治疗哺乳动物癌症的方法。
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2.发明授权Substituted oxazolo- and thizaolopyrimidinones as a mitotic kinesin inhibitor 失效取代的恶唑并噻唑并嘧啶酮作为有丝分裂驱动蛋白抑制剂公开(公告)号：US07262187B2
公开(公告)日：2007-08-28
申请号：US10497414
申请日：2002-12-02
IPC分类号： C07D487/04 , C07D413/12 , C07D243/08 , A61K31/519 , A61K31/497 , A61K31/5355 , A61K31/551
CPC分类号： C07D513/04
摘要： The present invention relates to azolopyrimidinone compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
摘要翻译： 本发明涉及可用于治疗细胞增殖性疾病，用于治疗与KSP驱动蛋白活性相关的病症和用于抑制KSP驱动蛋白的偶氮嘧啶酮化合物。 本发明还涉及包含这些化合物的组合物，以及使用它们治疗哺乳动物癌症的方法。
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![Substituted pyrazolo[3,4-d] pyrimidinones as a mitotic kinesin inhibitor](/abs-image/US/2007/08/28/US07262186B2/abs.jpg.150x150.jpg)
3.发明授权Substituted pyrazolo[3,4-d] pyrimidinones as a mitotic kinesin inhibitor 失效取代的吡唑并[3,4-d]嘧啶酮作为有丝分裂驱动蛋白抑制剂公开(公告)号：US07262186B2
公开(公告)日：2007-08-28
申请号：US10497385
申请日：2002-12-02
IPC分类号： C07D487/04 , C07D413/12 , C07D243/08 , A61K31/519 , A61K31/497 , A61K31/5355 , A61K31/551
CPC分类号： C07D487/04 , C07D519/00
摘要： The present invention relates to azolopyriniidinone compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
摘要翻译： 本发明涉及可用于治疗细胞增殖性疾病，用于治疗与KSP驱动蛋白活性相关的病症和用于抑制KSP驱动蛋白的偶氮吡啶酮酮化合物。 本发明还涉及包含这些化合物的组合物，以及使用它们治疗哺乳动物癌症的方法。
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公开(公告)号：US07109204B2
公开(公告)日：2006-09-19
申请号：US10485296
申请日：2002-07-26
申请人： Mark E. Fraley , Kenneth L. Arrington , William F. Hoffman , George D. Hartman , Jennifer P. Peckham
发明人： Mark E. Fraley , Kenneth L. Arrington , William F. Hoffman , George D. Hartman , Jennifer P. Peckham
IPC分类号： C07D403/04 , A61K31/506 , A61P35/00
CPC分类号： C07D403/04
摘要： The present invention relates to compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angiogenesis, cancer, tumor growth, atherosclerosis, age related macular degeneration, diabetic retinopathy, inflammatory diseases, and the like in mammals.
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公开(公告)号：US07186723B2
公开(公告)日：2007-03-06
申请号：US10487589
申请日：2002-08-26
申请人： Jennifer P. Peckham , William F. Hoffman , Kenneth L. Arrington , Mark E. Fraley , George D. Hartman , Yuntae Kim , Barbara Hanney , Keith L. Spencer
发明人： Jennifer P. Peckham , William F. Hoffman , Kenneth L. Arrington , Mark E. Fraley , George D. Hartman , Yuntae Kim , Barbara Hanney , Keith L. Spencer
IPC分类号： C07D241/04 , A61K31/4965
CPC分类号： C07D417/14 , C07D401/04 , C07D401/14
摘要： The present invention relates to compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angiogenesis, cancer, tumor growth, atherosclerosis, age related macular degeneration, diabetic retinopathy, inflammatory diseases, and the like in mammals.
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公开(公告)号：US06794393B1
公开(公告)日：2004-09-21
申请号：US10110872
申请日：2002-04-18
申请人： Mark E. Fraley , Kenneth L. Arrington , Mark T. Bilodeau , George D. Hartman , William F. Hoffman , Yuntae Kim , Randall W. Hungate
发明人： Mark E. Fraley , Kenneth L. Arrington , Mark T. Bilodeau , George D. Hartman , William F. Hoffman , Yuntae Kim , Randall W. Hungate
IPC分类号： C07D40114
CPC分类号： C07D401/14 , A61K31/495 , A61K45/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , A61K2300/00
摘要： The present invention relates to compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angiogenesis, cancer, tumor growth, atherosclerosis, age related macular degeneration, diabetic retinopathy, inflammatory diseases, and the like in mammals.
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公开(公告)号：US06306874B1
公开(公告)日：2001-10-23
申请号：US09690598
申请日：2000-10-17
申请人： Mark E. Fraley , Kenneth L. Arrington , Mark T. Bilodeau , George D. Hartman , William F. Hoffman , Yuntae Kim , Randall W. Hungate
发明人： Mark E. Fraley , Kenneth L. Arrington , Mark T. Bilodeau , George D. Hartman , William F. Hoffman , Yuntae Kim , Randall W. Hungate
IPC分类号： A01N4342
CPC分类号： C07D413/14 , A61K31/495 , A61K45/06 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14 , A61K2300/00
摘要： The present invention relates to compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angiogenesis, cancer, tumor growth, atherosclerosis, age related macular degeneration, diabetic retinopathy, inflammatory diseases, and the like in mammals.
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公开(公告)号：US07348440B2
公开(公告)日：2008-03-25
申请号：US10517559
申请日：2003-06-12
申请人： Kenneth L. Arrington , Paul J. Coleman , Christopher D. Cox , Mark E. Fraley , Robert M. Garbaccio , George D. Hartman , William F. Hoffman , Edward S. Tasber
发明人： Kenneth L. Arrington , Paul J. Coleman , Christopher D. Cox , Mark E. Fraley , Robert M. Garbaccio , George D. Hartman , William F. Hoffman , Edward S. Tasber
IPC分类号： C07D207/00 , C07D403/00 , C07D213/00 , C07D401/00 , C07D271/00 , C07D277/20 , C07D261/06 , C07D285/14 , C07D249/08 , C07D231/00 , A61K31/535 , A61K31/497 , A01N43/40 , A01N43/82 , A01N43/80 , A01N43/64 , A01N43/56 , A01N43/36
CPC分类号： C07D401/12 , C07D207/14 , C07D207/20 , C07D207/48 , C07D265/30 , C07D401/06 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/06 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/12
摘要： The present invention relates to dihydropyrrole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
摘要翻译： 本发明涉及可用于治疗细胞增殖性疾病，用于治疗与KSP驱动蛋白活性相关的病症和用于抑制KSP驱动蛋白的二氢吡咯化合物。 本发明还涉及包含这些化合物的组合物，以及使用它们治疗哺乳动物癌症的方法。
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公开(公告)号：US20080274107A1
公开(公告)日：2008-11-06
申请号：US12148649
申请日：2008-04-21
申请人： Mark E. Fraley , Kenneth L. Arrington , Mark T. Bilodeau , George D. Hartman , William F. Hoffman , Yuntae Kim , Randall W. Hungate
发明人： Mark E. Fraley , Kenneth L. Arrington , Mark T. Bilodeau , George D. Hartman , William F. Hoffman , Yuntae Kim , Randall W. Hungate
IPC分类号： A61K39/395 , C07D215/20 , A61K31/337 , A61K31/445 , A61K31/47 , A61P43/00
CPC分类号： C07D401/14 , A61K31/495 , A61K45/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , A61K2300/00
摘要： The present invention relates to compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angiogenesis, cancer, tumor growth, atherosclerosis, age related macular degeneration, diabetic retinopathy, inflammatory diseases, and the like in mammals.
摘要翻译： 本发明涉及抑制，调节和/或调节酪氨酸激酶信号转导的化合物，含有这些化合物的组合物及其用于治疗酪氨酸激酶依赖性疾病和病症如血管生成，癌症，肿瘤生长，动脉粥样硬化的方法 ，年龄相关性黄斑变性，糖尿病性视网膜病变，炎症性疾病等。
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公开(公告)号：US07378411B2
公开(公告)日：2008-05-27
申请号：US10497553
申请日：2002-12-02
IPC分类号： C07D495/04 , C07D413/06 , C07D413/08 , C07D243/08 , C07D243/14 , C07D245/02 , C07D245/06 , A61K31/519 , A61K31/5355 , A61K31/551 , A61K31/5513 , A61P35/04
CPC分类号： C07D495/04 , C07D519/00
摘要： The present invention relates to thienopyrimidinone compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
摘要翻译： 本发明涉及可用于治疗细胞增殖性疾病，用于治疗与KSP驱动蛋白活性相关的病症和用于抑制KSP驱动蛋白的噻吩并嘧啶酮化合物。 本发明还涉及包含这些化合物的组合物，以及使用它们治疗哺乳动物癌症的方法。
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