公开(公告)号：US20240359180A1

公开(公告)日：2024-10-31

申请号：US18541650

申请日：2023-12-15

Applicant: Mammoth Biosciences, Inc.

Inventor： Timothy James PATNO ,  Phillip You Fai LEE ,  Benjamin Andrew BLIZARD ,  Xin MIAO ,  Jacob LESINSKI ,  Ryan A. BROWN ,  Daniel Thomas DRZAL ,  Sarah Jane SHAPIRO ,  Joshua BAIK ,  Janice Sha CHEN ,  James Paul BROUGHTON ,  Clare Louise FASCHING ,  Jesus CHING ,  Sonal JAIN ,  Deepika VERMA ,  Matthew VEROSLOFF ,  Devin SPRATT ,  Nicholas John FANTIN

IPC: B01L3/00

CPC classification number: B01L3/502761 ,  B01L2200/0647 ,  B01L2200/0684 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2300/0663 ,  B01L2300/161 ,  B01L2300/1805 ,  B01L2400/06

Abstract: The present disclosure provides various systems, diagnostic devices, and methods for nucleic acid analysis. The systems, devices, and methods allow for the analysis of nucleic acids, in a sample, via programmable nuclease-based assays. Provided are systems comprising an instrument and a cartridge allowing for point of care use. The systems, devices, and methods described herein can be configured for multiplexed detection of nucleic acids in a single sample.

公开(公告)号：US20230159992A1

公开(公告)日：2023-05-25

申请号：US18155675

申请日：2023-01-17

Applicant: Mammoth Biosciences, Inc.

Inventor： Timothy James PATNO ,  Jesus CHING ,  James Paul BROUGHTON ,  Xin MIAO ,  Janice Sha CHEN ,  Clare Louise FASCHING ,  Alexander HIRSCHI ,  Raymond Weibang MEI ,  Wesley Wendell ADDISON, II ,  Nazmiye Emel ALPAY ,  Farzaneh TONDNEVIS ,  Sara ANSALONI ,  Deepika VERMA

IPC: C12Q1/6823 ,  C12Q1/6806 ,  C12Q1/6883 ,  C12Q1/70

CPC classification number: C12Q1/6823 ,  C12Q1/6806 ,  C12Q1/6883 ,  C12Q1/701 ,  C12Q2600/156

Abstract: Disclosed herein are systems and methods for providing a high-throughput DETECTR assay in a single chamber. The single chamber may be one well of a microplate, and multiple assays may be conducted in a staggered fashion in separate chambers. The methods described herein implement a process including lysing a sample, isolating nucleic acid molecules, eluting the nucleic acid molecules, amplifying the nucleic acid molecules, and detecting a presence of a target nucleic acid.