公开(公告)号：US12071710B2

公开(公告)日：2024-08-27

申请号：US17058124

申请日：2019-05-31

申请人： MOGAM INSTITUTE FOR BIOMEDICAL RESEARCH

发明人： Dong-Sik Kim ,  Mi Jung Lee ,  Mi Young Oh ,  Hye-Ji Choi ,  Gil-Jung Kim ,  Shin A Jang ,  Ae Rin Yoon

IPC分类号： C40B40/10 ,  C07K16/00 ,  C07K16/28 ,  C12N15/10

CPC分类号： C40B40/10 ,  C07K16/005 ,  C07K16/28 ,  C12N15/1037 ,  C07K2317/40 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/94

摘要： The present invention relates to a novel antibody library and an antibody-screening method using same. Having a human sequence-derived specific VH or VL scaffold, the antibody library according to the present invention exhibits high thermodynamic stability and enjoys the advantages of allowing high soluble expression as well as reversible folding. In addition, the antibody according to the present invention includes a variety of rationally controlled CDRs so as to exhibit high specificity and high affinity to all antigens and thus can be advantageously used for selecting an adequate candidate antibody against a target antigen.

公开(公告)号：US11447559B2

公开(公告)日：2022-09-20

申请号：US16649225

申请日：2018-09-21

申请人： MOGAM INSTITUTE FOR BIOMEDICAL RESEARCH ,  GREEN CROSS CORPORATION ,  DANA-FARBER CANCER INSTITUTE, INC.

发明人： Hye-Ji Choi ,  Jae-Chan Park ,  Hyung-Kwon Lim

IPC分类号： C07K16/28 ,  A61K39/395 ,  C12N15/63 ,  A61K39/00

摘要： Provided according to an embodiment of the present invention is an antibody that binds specifically to B-cell maturation antigen (BCMA) and comprises a heavy chain variable domain (VH domain) composed of a sequence having a homology of 80% or higher with any one of the amino acid sequences of SEQ ID NOS: 1 to 20, or a fragment thereof.