公开(公告)号：US20220244264A1

公开(公告)日：2022-08-04

申请号：US17725388

申请日：2022-04-20

申请人： MILTENYI BIOTEC B.V. & CO. KG

发明人： Stefan Miltenyi ,  Winfried Schimmelpfenning ,  Holger Lantow ,  Niklas Eimar Neuschaefer ,  Martin Biehl ,  Eiad Kabaha ,  Juergen Schulz

IPC分类号： G01N33/58 ,  A61M1/36 ,  B03C1/28 ,  B04B5/04 ,  B04B13/00 ,  B03C1/032 ,  B03C1/00 ,  B03C1/027 ,  B03C1/033 ,  B03C1/034 ,  A61M1/02 ,  G01N35/00 ,  C12N5/00 ,  C12M1/26 ,  C12M1/00 ,  B01D21/26 ,  B04B5/00 ,  B04B5/10 ,  B04B1/12 ,  B04B7/08 ,  B01D15/38 ,  C12N5/0789 ,  C12N5/077 ,  C12N5/0783 ,  C12M1/36

摘要： The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.