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公开(公告)号：US10508108B2
公开(公告)日：2019-12-17
申请号：US15532552
申请日：2015-12-01
发明人： Christian Fischer , Stephane L. Bogen , Matthew L. Childers , Francesc Xavier Fradera Llinas , J. Michael Ellis , Sara Esposite , Dawn M. Hoffman , Chunhui Huang , Solomon D. Kattar , Alexander J. Kim , John W. Lampe , Michelle R. Machacek , Daniel R. McMasters , Dann L. Parker, Jr. , Michael H. Reutershan , Nunzio Sciammetta , Pengcheng P. Shao , David L. Sloman , Wanying Sun , Feroze Ujjainwalla , Zhicai Wu , Yang Yu , Craig R. Gibeau
IPC分类号： C07D471/04 , C07D471/14 , C07D519/00
摘要： The present invention is directed to tricyclic compounds of formula (I) which are inhibitors of one or more mutant IDH enzymes (I); wherein A is —C(R1)═ or —N═; and X is selected from the group consisting of: (II-i), and (II-ii). The present invention is also directed to uses of the tricyclic compounds described herein in the potential treatment or prevention of cancers in which one or more mutant IDH enzymes are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such cancers.
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公开(公告)号：US20170369507A1
公开(公告)日：2017-12-28
申请号：US15532549
申请日：2015-12-01
发明人： Fischer Christian , Stephane L. Bogen , Matthew L. Childers , Francesc Xavier Fradera Llinas , Michael J. Ellis , Sara Esposite , Qingmei Hong , Chunhui Huang , Alexander J. Kim , John W. Lampe , Michelle R. Machacek , Daniel R. McMasters , Ryan D. Otte , Dann L. Parker, Jr. , Michael H. Reutershan , Nunzio Sciammetta , Patrick Pengcheng Shao , David L. Sloman , Feroze Ujjainwalla , Catherine White , Zhicai Wu , Yang Yu , Kake Zhao , Craig R. Gibeau
IPC分类号： C07D498/08 , C07D471/04 , C07D498/10 , C07D471/08 , A01N43/00
CPC分类号： C07D498/08 , A01N43/00 , A61K31/551 , C07D471/04 , C07D471/08 , C07D471/14 , C07D498/04 , C07D498/10
摘要： The present invention is directed to tricyclic compounds of formula (I) which are inhibitors of one or more mutant IDH enzymes: (I). The present invention is also directed to uses of the tricyclic compounds described herein in the potential treatment or prevention of cancers in which one or more mutant IDH enzymes are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such cancers.
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公开(公告)号：US20170362220A1
公开(公告)日：2017-12-21
申请号：US15532552
申请日：2015-12-01
发明人： Christian Fischer , Stephane L. Bogen , Matthew L. Childers , Francesc Xavier Fradera Llinas , Michael J. Ellis , Sara Esposite , Dawn M. Hoffman , Chunhui Huang , Solomon D. Kattar , Alexander J. Kim , John W. Lampe , Michelle R. Machacek , Daniel R. McMasters , Dann L. Parker, Jr. , Michael H. Reutershan , Nunzio Sciammetta , Patrick Pengcheng Shao , David L. Sloman , Wanying Sun , Feroze Ujjainwalla , Zhicai Wu , Yang Yu , Craig R. Gibeau
IPC分类号： C07D471/04 , C07D519/00 , C07D471/14
CPC分类号： C07D471/04 , C07D471/14 , C07D519/00
摘要： The present invention is directed to tricyclic compounds of formula (I) which are inhibitors of one or more mutant IDH enzymes (I); wherein A is —C(R1)═ or —N═; and X is selected from the group consisting of: (II-i), and (II-ii). The present invention is also directed to uses of the tricyclic compounds described herein in the potential treatment or prevention of cancers in which one or more mutant IDH enzymes are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such cancers.
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公开(公告)号：US20140323482A1
公开(公告)日：2014-10-30
申请号：US14366466
申请日：2012-12-17
发明人： Yao Ma , Manami Shizuka , Timothy J. Guzi , Yuan Liu , Yuan Tian , Brian R. Lahue , Craig R. Gibeau , Gerald W. Shipps, JR. , Yaolin Wang , Stephane L. Bogen , Latha G. Nair , Weidong Pan , Mark A. McCoy , Matthew E. Voss , Margarita Kirova-Snover , W. Bent Clayton
IPC分类号： C07D495/04 , C07D409/14
CPC分类号： C07D495/04 , C07D409/14
摘要： The present invention provides a compound of Formula I (The formula should be inserted here) as described herein or a pharmaceutically acceptable salt or solvate thereof. The representative compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same.
摘要翻译： 本发明提供如本文所述的式I化合物（该式应该在此插入）或其药学上可接受的盐或溶剂化物。 代表性化合物可用作HDM2蛋白的抑制剂。 还公开了包含上述化合物的药物组合物和使用其治疗癌症的潜在方法。
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公开(公告)号：US20230018413A1
公开(公告)日：2023-01-19
申请号：US17632065
申请日：2020-08-03
发明人： Stephane L. Bogen , Ping Chen , Dane James Clausen , Jinsong Hao , Dipannita Kalyani , Michael T. Rudd , Shawn P. Walsh , Lan Wei , Dexi Yang
IPC分类号： C07D403/04 , C07D207/14 , C07D401/04 , C07D471/04 , C07D417/04 , C07D413/10 , C07D417/14 , C07D413/04 , C07D409/04 , C07D405/04 , C07D498/04 , C07D491/048
摘要： The present invention is directed to heteroaryl pyrrolidine and piperidine compounds which are agonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved.
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公开(公告)号：US20220144771A1
公开(公告)日：2022-05-12
申请号：US17430409
申请日：2020-02-11
发明人： Stephane L. Bogen , Michael J. Breslin , Dane James Clausen , Anthony Ginnetti , Michael T. Rudd , Shawn J. Stachel , Craig A. Stump , Dexi Yang
IPC分类号： C07D207/14
摘要： The present invention is directed to pyrrolidine compounds which are agonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved.
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公开(公告)号：US20180305352A1
公开(公告)日：2018-10-25
申请号：US15769414
申请日：2016-10-25
发明人： David J. Witter , Tesfaye Biftu , Purakkattle Biju , Stephane L. Bogen , Qingmei Hong , Chunhui Huang , Xianhai Huang , Bing Li , Min K. Park , David L. Sloman
IPC分类号： C07D471/04 , C07D519/00 , A61P35/02
CPC分类号： C07D471/04 , A61P35/02 , C07D491/10 , C07D498/08 , C07D519/00
摘要： The present invention is directed to tricyclic compounds of formula (I), (Ia) or (Ib) which are inhibitors of one or more mutant IDH enzymes. The present invention is also directed to uses of these tricyclic compounds in the potential treatment or prevention of cancers in which one or more mutant IDH enzymes are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such cancers.
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公开(公告)号：US09637493B2
公开(公告)日：2017-05-02
申请号：US14652466
申请日：2013-12-18
发明人： Christopher Dinsmore , Francesc Xavier Fradera Llinas , Amit Ashokro Kudale , Michelle Machacek , Michael Hale Reutershan , Christopher Francis Thompson , B. Wesley Trotter , Liping Yang , Michael D. Altman , Stephane L. Bogen , Ronald J. Doll , Matthew E. Voss
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00
CPC分类号： C07D487/04
摘要： The present invention provides substituted pyrrolopyrimidines of Formula I as described herein or a pharmaceutically acceptable salt or solvate thereof: The representative compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same.
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公开(公告)号：US09540377B2
公开(公告)日：2017-01-10
申请号：US14762827
申请日：2014-01-29
发明人： Carolyn Michele Cammarano , Matthew P. Christopher , Christopher Dinsmore , Ronald J. Doll , Francesc Xavier Fradera Llinas , Chaomin Li , Michelle Machacek , Michelle Martinez , Latha G. Nair , Weidong Pan , Michael Hale Reutershan , Manami Shizuka , Dietrich P. Steinhuebel , Binyuan Sun , Christopher Francis Thompson , B. Wesley Trotter , Yaolin Wang , Liping Yang , Stephane L. Bogen , Matthew E. Voss , Jagannath Panda , Anthappan Tony Kurissery
IPC分类号： A61K31/52 , C07D473/16 , C07D473/00 , C07D473/34 , C07D473/30
CPC分类号： C07D473/00 , C07D473/16 , C07D473/30 , C07D473/34
摘要： The present invention provides 2,6,7,8 Substituted Purines as described herein or a pharmaceutically acceptable salt thereof. The representative compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same.
摘要翻译： 本发明提供如本文所述的2,6,7,8取代的嘌呤或其药学上可接受的盐。 代表性化合物可用作HDM2蛋白的抑制剂。 还公开了包含上述化合物的药物组合物和使用其治疗癌症的潜在方法。
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10.发明申请2'-ALKYNYL SUBSTITUTED NUCLEOSIDE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES 有权2'-烷基取代的核苷衍生物及其用于治疗病毒性疾病的方法公开(公告)号：US20150299243A1
公开(公告)日：2015-10-22
申请号：US14443922
申请日：2013-11-14
申请人： Frank BENNETT , Yuhua HUANG , Lingyan WANG , Stephane L. BOGEN , Angela D. KEREKES , Vinay M. GIRIJAVALLABHAN , Gabor BUTORA , Quang TRUONG , Ian DAVIES , Anne E. WEBER , MERCK SHARP & DOHME CORP.
发明人： Frank Bennett , Yuhua Huang , Lingyan Wang , Stephane L. Bogen , Angela D. Kerekes , Vinay M. Girijavallabhan M. Girijavallabhan , Gabor Butora , Quang Truong , Ian Davies , Ann E. Weber
IPC分类号： C07H19/10 , A61K31/7072 , A61K45/06 , C07H19/06
CPC分类号： C07H19/10 , A61K31/706 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K45/06 , C07H19/06 , C07H19/067 , C07H19/09 , C07H19/11
摘要： The present invention relates to 2′-Alkynyl Substituted Nucleoside Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein B, X, R1, R2, R3 and R4 are as defined herein. The present invention also relates to compositions comprising at least one 2′-Alkynyl Substituted Nucleoside Derivative, and methods of using the 2′-Alkynyl Substituted Nucleoside Derivatives for treating or preventing HCV infection in a patient.
摘要翻译： 本发明涉及式（I）的2'-炔炔基取代的核苷衍生物及其药学上可接受的盐，其中B，X，R 1，R 2，R 3和R 4如本文所定义。 本发明还涉及包含至少一种2'-炔基取代的核苷衍生物的组合物，以及使用2'-炔基取代的核苷衍生物治疗或预防患者HCV感染的方法。
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