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公开(公告)号：US20170369507A1
公开(公告)日：2017-12-28
申请号：US15532549
申请日：2015-12-01
发明人： Fischer Christian , Stephane L. Bogen , Matthew L. Childers , Francesc Xavier Fradera Llinas , Michael J. Ellis , Sara Esposite , Qingmei Hong , Chunhui Huang , Alexander J. Kim , John W. Lampe , Michelle R. Machacek , Daniel R. McMasters , Ryan D. Otte , Dann L. Parker, Jr. , Michael H. Reutershan , Nunzio Sciammetta , Patrick Pengcheng Shao , David L. Sloman , Feroze Ujjainwalla , Catherine White , Zhicai Wu , Yang Yu , Kake Zhao , Craig R. Gibeau
IPC分类号： C07D498/08 , C07D471/04 , C07D498/10 , C07D471/08 , A01N43/00
CPC分类号： C07D498/08 , A01N43/00 , A61K31/551 , C07D471/04 , C07D471/08 , C07D471/14 , C07D498/04 , C07D498/10
摘要： The present invention is directed to tricyclic compounds of formula (I) which are inhibitors of one or more mutant IDH enzymes: (I). The present invention is also directed to uses of the tricyclic compounds described herein in the potential treatment or prevention of cancers in which one or more mutant IDH enzymes are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such cancers.
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2.发明申请CARBAMATE BENZOXAZINE PROPIONIC ACIDS AND ACID DERIVATIVES FOR MODULATION OF RORgamma ACTIVITY AND THE TREATMENT OF DISEASE 有权用于调节罗丹明活性和疾病治疗的碳酸酯苯并咪唑酸和酸衍生物公开(公告)号：US20160311787A1
公开(公告)日：2016-10-27
申请号：US15103409
申请日：2014-12-19
发明人： Thomas D. Aicher , Chad A. VanHuis , John MacLean , Brian M. Andresen , Kenneth J. Barr , Corey Bienstock , Matthew Daniels , Kun Liu , Yuan Liu , Catherine White , Nunzio Sciammetta , Vladimir Simov
IPC分类号： C07D265/36 , C07D413/12 , C07D417/12 , C07D471/04 , C07D513/04 , A61K31/538 , C07D487/04
CPC分类号： C07D265/36 , A61K31/538 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D513/04
摘要： The invention provides certain benzoxazine compounds of the Formula (I) or pharmaceutically acceptable salts thereof wherein R1, R2, Ra1, Ra2, Rb1, Rb2, Rc, Rd, and Cy are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds of the Formula (I) or pharmaceutically acceptable salts thereof, and methods of using the compounds of the Formula (I) or pharmaceutically acceptable salts thereof or pharmaceutical compositions comprising the same for treating diseases or conditions mediated by RORgammaT.
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公开(公告)号：US09226922B2
公开(公告)日：2016-01-05
申请号：US14431485
申请日：2013-09-26
发明人： Kevin J. Wilson , David J. Witter , Matthew H. Daniels , Angie R. Angeles , Phieng Siliphaivanh , David Sloman , Brendan O'Boyle , Danielle Falcone , Catherine White , Ron Ferguson , Wei Zhou , Kathryn Lipford , Umar Faruk Mansoor , Salem Fevrier , Xianhai Huang , Ravi Kurukulasuriya , Judson E. Richard , Shuyi Tang , Christopher Boyce , Joseph Kozlowski , Raman Kumar Bakshi , Ganesh Babu Karunakaran
IPC分类号： C07D401/14 , A61K31/437 , C07D471/04 , A61K45/06 , A61K31/4545
CPC分类号： A61K31/437 , A61K31/4545 , A61K45/06 , C07D471/04
摘要： Disclosed are the ERK inhibitors of formula (1.0), having a pyrazolopyridine base structure, and the pharmaceutically acceptable salts thereof. Also disclosed are methods of treating cancer using the compounds of formula (1.0).
摘要翻译： 公开了具有吡唑并吡啶基结构的式（1.0）的ERK抑制剂及其药学上可接受的盐。 还公开了使用式（1.0）化合物治疗癌症的方法。
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公开(公告)号：US20200216425A1
公开(公告)日：2020-07-09
申请号：US16819325
申请日：2020-03-16
发明人： Yongxin Han , Abdelghani Achab , Yongqi Deng , Xavier Fradera , Craig Gibeau , Brett A. Hopkins , Derun Li , Kun Liu , Meredeth A. McGowan , Nunzio Sciammetta , David Sloman , Catherine White , Hongjun Zhang , Hua Zhou
IPC分类号： C07D405/10 , A61K31/4427 , A61K31/4965 , C07D241/12 , A61K31/501 , C07D417/14 , A61K31/4418 , C07D213/56 , C07D401/04 , C07D413/04 , A61K31/513 , A61K31/444 , C07D405/14 , A61K31/4184 , A61K31/4245 , A61K31/41 , A61K31/427 , C07D417/10 , A61K31/337 , C07D305/08 , A61K31/4155 , A61K31/506 , A61K31/437 , C07D471/04 , A61K45/06 , A61K31/4523 , C07D413/14 , C07D209/46 , A61P31/00 , C07D405/04 , C07D401/12 , C07D413/10 , A61P35/00 , C07D231/12 , A61P37/00 , C07D263/32
摘要： Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof: Also disclosed herein are uses of a compound disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of a composition in the potential treatment or prevention of an IDO-associated disease or disorder.
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公开(公告)号：US20190144433A1
公开(公告)日：2019-05-16
申请号：US16186769
申请日：2018-11-12
发明人： Yongxin Han , Abdelghani Achab , Yongqi Deng , Xavier Fradera , Craig Gibeau , Brett A. Hopkins , Derun Li , Kun Liu , Meredeth A. McGowan , Nunzio Sciammetta , David Sloman , Catherine White , Hongjun Zhang , Hua Zhou
IPC分类号： C07D405/10 , A61K31/4427 , A61K45/06 , C07D471/04 , A61K31/437 , A61K31/506 , A61K31/4155 , C07D305/08 , A61K31/337 , C07D417/10 , A61K31/427 , A61K31/41 , A61K31/4245 , A61K31/4184 , C07D405/14 , A61K31/444 , A61K31/513 , C07D413/04 , C07D401/04 , C07D213/56 , A61K31/4418 , C07D417/14 , A61K31/501 , C07D241/12 , A61K31/4965 , A61K31/4523
摘要： Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof: Also disclosed herein are uses of a compound disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of a composition in the potential treatment or prevention of an IDO-associated disease or disorder.
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公开(公告)号：US09783511B2
公开(公告)日：2017-10-10
申请号：US15103409
申请日：2014-12-19
发明人： Thomas D. Aicher , Chad A. VanHuis , John MacLean , Brian M. Andresen , Kenneth J. Barr , Corey Bienstock , Matthew Daniels , Kun Liu , Yuan Liu , Catherine White , Nunzio Sciammetta , Vladimir Simov
IPC分类号： C07D265/36 , A61K31/538 , C07D413/12 , C07D513/04 , C07D417/12 , C07D471/04 , C07D487/04
CPC分类号： C07D265/36 , A61K31/538 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D513/04
摘要： The invention provides certain benzoxazine compounds of the Formula (I) or pharmaceutically acceptable salts thereof wherein R1, R2, Ra1, Ra2, Rb1, Rb2, Rc, Rd, and Cy are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds of the Formula (I) or pharmaceutically acceptable salts thereof, and methods of using the compounds of the Formula (I) or pharmaceutically acceptable salts thereof or pharmaceutical compositions comprising the same for treating diseases or conditions mediated by RORgammaT.
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公开(公告)号：US09663502B2
公开(公告)日：2017-05-30
申请号：US15103407
申请日：2014-12-19
发明人： Thomas D. Aicher , Chad A. VanHuis , John MacLean , Brian M. Andresen , Kenneth J. Barr , Corey Bienstock , Neville J. Anthony , Matthew Daniels , Yuan Liu , Catherine White , Blair T. Lapointe , Nunzio Sciammetta , Vladimir Simov , Wesley B. Trotter , Kun Liu
IPC分类号： C07D265/36 , C07D413/12 , C07D471/04 , A61K31/538 , A61K45/06 , C07D413/14 , C07D417/12 , C07D487/04 , C07D498/04 , C07D513/04
CPC分类号： C07D413/12 , A61K31/538 , A61K45/06 , C07D265/36 , C07D413/14 , C07D417/12 , C07D471/04 , C07D487/04 , C07D498/04 , C07D513/04
摘要： The invention provides certain benzoxazine compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, Ra, Rb, Rc, Rd, Rg, and Cy are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds of the Formula (I) or pharmaceutically acceptable salts thereof, and methods of using the compounds of the Formula (I) or pharmaceutically acceptable salts thereof or pharmaceutical compositions comprising the same for treating diseases or conditions mediated by RORgammaT.
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公开(公告)号：US10995085B2
公开(公告)日：2021-05-04
申请号：US16819325
申请日：2020-03-16
发明人： Yongxin Han , Abdelghani Achab , Yongqi Deng , Xavier Fradera , Craig Gibeau , Brett A. Hopkins , Derun Li , Kun Liu , Meredeth A. McGowan , Nunzio Sciammetta , David Sloman , Catherine White , Hongjun Zhang , Hua Zhou
IPC分类号： C07D405/10 , A61K31/4523 , A61K45/06 , C07D471/04 , A61K31/437 , A61K31/506 , A61K31/4155 , C07D305/08 , A61K31/337 , C07D417/10 , A61K31/427 , A61K31/41 , A61K31/4245 , A61K31/4184 , C07D405/14 , A61K31/444 , A61K31/513 , C07D413/04 , C07D401/04 , C07D213/56 , A61K31/4418 , C07D417/14 , A61K31/501 , C07D241/12 , A61K31/4965 , A61K31/4427 , C07D263/32 , A61P37/00 , C07D231/12 , A61P35/00 , C07D413/10 , C07D401/12 , C07D405/04 , A61P31/00 , C07D209/46 , C07D413/14
摘要： Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof: Also disclosed herein are uses of a compound disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of a composition in the potential treatment or prevention of an IDO-associated disease or disorder.
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公开(公告)号：US20200215042A1
公开(公告)日：2020-07-09
申请号：US16631192
申请日：2018-07-30
发明人： Hua Zhou , Xavier Fradera , Yongxin Han , Meredeth A. McGowan , Nunzio Sciammetta , Catherine White , Wensheng Yu
IPC分类号： A61K31/444 , A61K45/06 , C07D471/04 , C07D401/08 , C07D401/14 , A61K31/4439
摘要： Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof: (I). Also disclosed herein are uses of the compounds disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.
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公开(公告)号：US10647705B2
公开(公告)日：2020-05-12
申请号：US16186769
申请日：2018-11-12
发明人： Yongxin Han , Abdelghani Achab , Yongqi Deng , Xavier Fradera , Craig Gibeau , Brett A. Hopkins , Derun Li , Kun Liu , Meredeth A. McGowan , Nunzio Sciammetta , David Sloman , Catherine White , Hongjun Zhang , Hua Zhou
IPC分类号： C07D405/10 , A61K31/4523 , A61K45/06 , C07D471/04 , A61K31/437 , A61K31/506 , A61K31/4155 , C07D305/08 , A61K31/337 , C07D417/10 , A61K31/427 , A61K31/41 , A61K31/4245 , A61K31/4184 , C07D405/14 , A61K31/444 , A61K31/513 , C07D413/04 , C07D401/04 , C07D213/56 , A61K31/4418 , C07D417/14 , A61K31/501 , C07D241/12 , A61K31/4965 , A61K31/4427 , C07D263/32 , A61P37/00 , C07D231/12 , A61P35/00 , C07D413/10 , C07D401/12 , C07D405/04 , A61P31/00 , C07D209/46 , C07D413/14
摘要： Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof: Also disclosed herein are uses of a compound disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of a composition in the potential treatment or prevention of an IDO-associated disease or disorder.
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