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1.发明申请METHODS FOR TREATING CHRONIC OBSTRUCTIVE PULMONARY DISEASE USING BENRALIZUMAB 审中-公开使用BENRALIZUMAB治疗慢性阻塞性肺疾病的方法公开(公告)号：US20150104447A1
公开(公告)日：2015-04-16
申请号：US14513866
申请日：2014-10-14
Applicant: MedImmune, LLC
Inventor： Rene van der Merwe , Christine Ward , Ubaldo Martin , Lorin Roskos , Bing Wang
IPC: C07K16/28
CPC classification number: C07K16/2866 , A61K2039/505 , A61K2039/545 , A61P11/00 , C07K2317/24
Abstract: Provided herein is are methods of treating Chronic Obstructive Pulmonary Disease (COPD) in a patient, comprising administering to the patient an effective amount of benralizumab or an antigen-binding fragment thereof.
Abstract translation: 本文提供了治疗患者中慢性阻塞性肺病（COPD）的方法，其包括向患者施用有效量的苯那霉素或其抗原结合片段。
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公开(公告)号：US20230420081A1
公开(公告)日：2023-12-28
申请号：US18367923
申请日：2023-09-13
Applicant: MEDIMMUNE, LLC
Inventor： Li Yu , Harry Yang , Mohammed Dar , Lorin Roskos , Jean-Charles Soria , Charles Ferte , Wei Zhao , Aline Gendrin Brokmann , Jolyon Faria , Pralay Mukhopadhyay , Ikbel Achour
CPC classification number: G16B40/20 , G16B5/20 , G06N20/20 , G16H50/20 , G16H50/50 , G16H50/30 , G06N5/01 , G16H20/40
Abstract: Methods for determining treatments for cancer patients are disclosed.
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公开(公告)号：US09441037B2
公开(公告)日：2016-09-13
申请号：US14453942
申请日：2014-08-07
Applicant: MedImmune, LLC
Inventor： Christine Ward , Lorin Roskos , Bing Wang , Donald Raible
IPC: C07K16/28 , A61K45/06 , A61K39/395 , C07K16/24 , A61K39/00
CPC classification number: C07K16/2866 , A61K39/395 , A61K2039/505 , A61K2039/545 , C07K16/244 , C07K2317/24 , C07K2317/76
Abstract: Provided herein is are methods of reducing exacerbations of asthma in an asthma patient, comprising administering to the patient an effective amount of the anti-interleukin-5 receptor (IL-5R) antibody benralizumab or an antigen-binding fragment thereof.
Abstract translation: 本文提供减少哮喘患者哮喘恶化的方法，其包括向患者施用有效量的抗白细胞介素-5受体（IL-5R）抗体苯那珠单抗或其抗原结合片段。
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4.发明申请Methods For Increasing Forced Expiratory Volume In Asthmatics Using Benralizumab 有权使用贝那珠单抗增加哮喘患者呼气量的方法公开(公告)号：US20150044203A1
公开(公告)日：2015-02-12
申请号：US14454138
申请日：2014-08-07
Applicant: MedImmune, LLC
Inventor： Christine Ward , Lorin Roskos , Bing Wang , Donald Raible
IPC: C07K16/28 , A61K45/06 , A61K39/395
CPC classification number: C07K16/2866 , A61K45/06 , A61K2039/505 , C07K2317/24
Abstract: Provided herein is are methods of increasing forced expiratory volume in one second (FEV1) in an asthma patient, comprising administering to the patient an effective amount of benralizumab or an antigen-binding fragment thereof.
Abstract translation: 本文提供的是在哮喘患者中增加一秒钟（FEV1）中的呼气量的方法，包括向患者施用有效量的苯那霉素或其抗原结合片段。
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公开(公告)号：US12224043B2
公开(公告)日：2025-02-11
申请号：US18367923
申请日：2023-09-13
Applicant: MEDIMMUNE, LLC
Inventor： Li Yu , Harry Yang , Mohammed Dar , Lorin Roskos , Jean-Charles Soria , Charles Ferte , Wei Zhao , Aline Gendrin Brokmann , Jolyon Faria , Pralay Mukhopadhyay , Ikbel Achour
IPC: G16B40/20 , G06N5/01 , G06N20/20 , G16B5/20 , G16H20/40 , G16H50/20 , G16H50/30 , G16H50/50 , A61K38/00 , C07K16/28 , G01N33/574
Abstract: Methods for determining treatments for cancer patients are disclosed.
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Patent Agency Ranking
公开(公告)号：US20170107291A1
公开(公告)日：2017-04-20
申请号：US15168711
申请日：2016-05-31
Applicant: MedImmune, LLC
Inventor： Rene van der Merwe , Christine Ward , Ubaldo Martin , Lorin Roskos , Bing Wang
IPC: C07K16/28
CPC classification number: C07K16/2866 , A61K2039/505 , A61K2039/545 , A61P11/00 , C07K2317/24
Abstract: Provided herein is are methods of treating Chronic Obstructive Pulmonary Disease (COPD) in a patient, comprising administering to the patient an effective amount of benralizumab or an antigen-binding fragment thereof.
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7.发明授权Fixed dosage regimens for anti-type I interferon receptor (IFNAR) antibodies 有权抗I型干扰素受体（IFNAR）抗体的固定剂量方案公开(公告)号：US09493570B2
公开(公告)日：2016-11-15
申请号：US14407156
申请日：2013-06-12
Applicant: MedImmune, LLC
Inventor： Brandon Higgs , Yihong Yao , Bing Wang , Lorin Roskos , Linda Chang
CPC classification number: C07K16/2866 , A61K38/00 , A61K39/00 , A61K2039/505 , A61K2039/54 , A61K2039/545 , C07K2317/21 , C07K2317/76 , C07K2317/77 , C07K2317/90 , C07K2317/94 , C12Q1/6883 , C12Q2600/106 , C12Q2600/158 , C12Q2600/16 , G06F19/00 , G06N7/005 , G16H50/20
Abstract: The disclosure provides methods for treating a subject having a type I IFN-mediated disease or disorder comprising administration of a fixed does of an anti-interferon alpha receptor antibody. The disclosure also provides methods for suppressing a type I interferon (IFN) gene signature (GS) in a subject. In addition, the disclosure provides methods of prognosing or monitoring disease progression in a subject having a type I IFN-mediated disease or disorder, methods of predicting a dosage regimen, methods of identifying a candidate therapeutic agent, methods of identifying a patient as a candidate for a therapeutic agent, and methods of designating a personalized therapy.
Abstract translation: 本公开提供了治疗患有I型IFN介导的疾病或病症的受试者的方法，包括施用固定的抗干扰素α受体抗体。 本公开还提供了抑制受试者中I型干扰素（IFN）基因特征（GS）的方法。 此外，本公开提供预测或监测具有I型IFN介导的疾病或病症的受试者的疾病进展的方法，预测剂量方案的方法，鉴定候选治疗剂的方法，鉴定患者作为候选者的方法 用于治疗剂，以及指定个性化疗法的方法。
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8.发明授权Methods for increasing forced expiratory volume in asthmatics using benralizumab 有权使用贝那珠单抗增加哮喘患者呼气量的方法公开(公告)号：US09441046B2
公开(公告)日：2016-09-13
申请号：US14454138
申请日：2014-08-07
Applicant: MedImmune, LLC
Inventor： Christine Ward , Lorin Roskos , Bing Wang , Donald Raible
IPC: C07K16/28 , A61K45/06 , A61K39/395 , A61K39/00
CPC classification number: C07K16/2866 , A61K45/06 , A61K2039/505 , C07K2317/24
Abstract: Provided herein is are methods of increasing forced expiratory volume in one second (FEV1) in an asthma patient, comprising administering to the patient an effective amount of benralizumab or an antigen-binding fragment thereof.
Abstract translation: 本文提供的是在哮喘患者中增加一秒钟（FEV1）中的呼气量的方法，包括向患者施用有效量的苯那霉素或其抗原结合片段。
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9.发明申请METHODS FOR REDUCING EXACERBATION RATES OF ASTHMA USING BENRALIZUMAB 有权降低使用BENRALIZUMAB的ASTHMA进行速率的方法公开(公告)号：US20150044202A1
公开(公告)日：2015-02-12
申请号：US14453942
申请日：2014-08-07
Applicant: MedImmune, LLC
Inventor： Christine Ward , Lorin Roskos , Bing Wang , Donald Raible
IPC: C07K16/24
CPC classification number: C07K16/2866 , A61K39/395 , A61K2039/505 , A61K2039/545 , C07K16/244 , C07K2317/24 , C07K2317/76
Abstract: Provided herein is are methods of reducing exacerbations of asthma in an asthma patient, comprising administering to the patient an effective amount of the anti-interleukin-5 receptor (IL-5R) antibody benralizumab or an antigen-binding fragment thereof.
Abstract translation: 本文提供减少哮喘患者哮喘恶化的方法，其包括向患者施用有效量的抗白细胞介素-5受体（IL-5R）抗体苯那珠单抗或其抗原结合片段。
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公开(公告)号：US11798653B2
公开(公告)日：2023-10-24
申请号：US16657375
申请日：2019-10-18
Applicant: MEDIMMUNE, LLC
Inventor： Li Yu , Harry Yang , Mohammed Dar , Lorin Roskos , Jean-Charles Soria , Charles Ferte , Wei Zhao , Aline Gendrin Brokmann , Jolyon Faria , Pralay Mukhopadhyay , Ikbel Achour
IPC: G16B40/20 , G16B5/20 , G06N20/20 , G16H50/20 , G16H50/50 , G16H50/30 , G06N5/01 , G16H20/40 , A61K38/00 , C07K16/28 , G01N33/574
CPC classification number: G16B40/20 , G06N5/01 , G06N20/20 , G16B5/20 , G16H50/20 , G16H50/30 , G16H50/50 , A61K38/00 , C07K16/2818 , G01N33/57484 , G16H20/40
Abstract: Methods for determining treatments for cancer patients are disclosed.
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