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公开(公告)号：US3928137A
公开(公告)日：1975-12-23
申请号：US46743174
申请日：1974-05-06
Applicant: MALLINCKRODT INC
Inventor： MONTE ALEXANDER A , CHIANG CHING
CPC classification number: G01N33/721 , C12Q1/62
Abstract: An enzyme reagent formulation for use in assaying a biological specimen for uric acid is prepared as a granular, water-soluble, anhydrous, storage-stable mixture containing uricase, potassium chloride, mannitol, gum acacia, bovine serum albumin, glycine, sodium carbonate and a nitrogen containing polyoxyalkylene nonionic surfactant obtained by the sequential reaction of ethylenediamine with propylene oxide and ethylene oxide in the presence of a catalyst. The surfactant contains polyoxypropylene chains having an average molecular weight of between about 750 and about 6750, and polyoxyethylene chains constituting between about 10 and about 80 weight percent of the surfactant. The surfactant has an advantageous effect upon granulation, dissolution and storage stability of the reagent formulation.
Abstract translation: 制备用于测定尿酸生物样本的酶试剂制剂，其为含有尿酸酶，氯化钾，甘露糖醇，阿拉伯胶，牛血清白蛋白，甘氨酸，碳酸钠的颗粒状，水溶性，无水，储存稳定的混合物。 通过在催化剂存在下通过乙二胺与环氧丙烷和环氧乙烷的顺序反应获得的含氮聚氧化烯非离子表面活性剂。 表面活性剂含有平均分子量在约750至约6750之间的聚氧丙烯链，构成表面活性剂约10至约80重量％的聚氧乙烯链。 表面活性剂对试剂制剂的造粒，溶解和储存稳定性具有有利的作用。
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公开(公告)号：US3926735A
公开(公告)日：1975-12-16
申请号：US46731974
申请日：1974-05-06
Applicant: MALLINCKRODT INC
Inventor： MONTE ALEXANDER A , CHIANG CHING
CPC classification number: C12Q1/42 , G01N33/721
Abstract: Alkaline phosphatase is assayed in biological specimens by using granular solid, water-soluble substantially anhydrous, storagestable reagent formulations containing a nitrogen bearing polyoxyalkylene nonionic surfactant obtained by the sequential reaction of ethylenediamine with propylene oxide and ethylene oxide in the presence of a catalyst. The surfactant has an advantageous effect upon granulation, stabilization and dissolution of the formulations, and is effective for solubilizing proteins such as enzymes in the formulations or the specimen.
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