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公开(公告)号:US20110200620A1
公开(公告)日:2011-08-18
申请号:US13012063
申请日:2011-01-24
申请人: Lieping CHEN , Scott E. STROME , Eugene D. KWON
发明人: Lieping CHEN , Scott E. STROME , Eugene D. KWON
IPC分类号: A61K39/395 , A61P35/00 , C12Q1/02 , G01N33/53 , C12Q1/68
CPC分类号: C07K16/2803 , A61K38/2013 , A61K38/2026 , A61K38/2066 , A61K38/208 , A61K38/2086 , A61K38/212 , A61K38/215 , A61K38/217 , A61K2039/505 , C07K16/2827 , C07K16/30 , C07K2317/24 , C07K2317/76 , C12N15/113 , C12N15/1138 , C12N2310/11 , C12N2310/14 , C12N2320/30 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158 , G01N33/5088 , G01N33/5091 , G01N33/56972 , G01N33/57407 , G01N33/57438 , G01N33/57484
摘要: The invention features methods of diagnosis by assessing B7-H1 expression in a tissue from a subject that has, or is suspected of having, cancer, methods of treatment with agents that interfere with B7-H1-receptor interaction, methods of selecting candidate subjects likely to benefit from cancer immunotherapy, and methods of inhibiting expression of B7-H1.
摘要翻译: 本发明的特征在于通过评估来自具有或被怀疑患有癌症的受试者的组织中的B7-H1表达,以及干扰B7-H1受体相互作用的试剂的治疗方法,可能地选择候选对象的方法 受益于癌症免疫治疗,以及抑制B7-H1表达的方法。