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1.发明申请ISOINDOLINE OR ISOQUINOLINE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 有权ISOINDOLINE或异喹啉化合物，其制备和含有它们的药物组合物的方法公开(公告)号：US20160194304A1
公开(公告)日：2016-07-07
申请号：US14905985
申请日：2014-07-22
发明人： James Edward Paul DAVIDSON , James Brooke MURRAY , I-Jen CHEN , Claire WALMSLEY , Mark DODSWORTH , Johannes W.G MEISSNER , Paul BROUGH , Imre FEJES , János TATAI , Miklós NYERGES , András KOTSCHY , Zoltán SZLÁVIK , Olivier GENESTE , Arnaud LE TIRAN
IPC分类号： C07D401/14 , A61K45/06 , A61K31/4725 , C07D417/14 , A61K31/497 , A61N5/10 , A61K31/496 , C07D409/14 , C07D405/14 , C07F9/6561 , A61K31/675 , A61K31/5377 , C07D471/04
CPC分类号： C07D401/14 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/5377 , A61K31/675 , A61K45/06 , A61N5/10 , C07D405/14 , C07D409/14 , C07D417/14 , C07D471/04 , C07F9/65616 , A61K2300/00
摘要： Compounds of formula (I): wherein Het, R3, R4, R5, R7, R8, R9, T, p, p′, q, and q′ are as defined in the description.Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
摘要翻译： 式（I）化合物：其中Het，R3，R4，R5，R7，R8，R9，T，p，p'，q和q'如说明书中所定义。 含有该物质的药物可用于治疗涉及细胞凋亡缺陷的病症，如癌症，自身免疫疾病和免疫系统疾病。
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2.发明申请公开(公告)号：US20200262816A1
公开(公告)日：2020-08-20
申请号：US16865799
申请日：2020-05-04
发明人： James Edward Paul DAVIDSON , James Brooke MURRAY , I-Jen CHEN , Claire WALMSLEY , Mark DODSWORTH , Johannes W.G. MEISSNER , Paul BROUGH , lmre FEJES , János TATAI , Miklós NYERGES , András KOTSCHY , Zoltán SZLÁVIK , Olivier GENESTE , Arnaud LE TIRAN , Thierry LE DIGUARHER , Jean-Michel HENLIN , Jérôme-Benoît STARCK , Anne-Françoise GUILLOUZIC , Guillaume DE NANTEUIL
IPC分类号： C07D401/14 , C07F9/6561 , C07D417/14 , A61N5/10 , A61K45/06 , A61K31/675 , A61K31/5377 , A61K31/497 , A61K31/496 , C07D471/04 , C07D409/14 , A61K31/4725 , C07D405/14
摘要： Compound of formula (I): wherein Het, R3, R4, R5, R7, R8, R9, t, p, p′, q, and q′ are as defined in the description.Medicinal products containing the same which are useful in treating conditions requiring pro-apoptotic agent.
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