公开(公告)号：US11846614B2

公开(公告)日：2023-12-19

申请号：US17385742

申请日：2021-07-26

Applicant: LECO Corporation

Inventor： Gaetano Stallone ,  Mark Firmer Merrick

IPC: G01N30/30 ,  G01N30/46

CPC classification number: G01N30/30 ,  G01N30/463 ,  G01N30/465 ,  G01N2030/303 ,  G01N2030/3023 ,  G01N2030/3053

Abstract: A method for modulating analytes in a gaseous stream passing through a capillary, wherein the analytes are retained in a trapping zone of the capillary, or allowed to pass therethrough, based on certain conditions. The method includes, during a first time period, heating the trapping zone of the capillary to a first temperature to desorb analytes therewithin and allow the analytes to pass therethrough, and during a second time period, cooling the capillary to a second temperature that is sufficient to trap and focus the analytes within the trapping zone. During the first time period, the method also includes retaining heat at the capillary during to minimize the load on a cooling device thermally connected thereto, and during the second time period, selectively allowing thermal transfer toward the cooling device.

公开(公告)号：US20220082535A1

公开(公告)日：2022-03-17

申请号：US17423090

申请日：2020-01-17

Applicant: LECO Corporation

Inventor： David Jesse Borton ,  Jonelle Ley Shiel ,  Mark Firmer Merrick

IPC: G01N30/46 ,  G01N30/88 ,  G01N30/16

Abstract: A multi-dimensional gas chromatograph for analyzing compounds in a sample during a single run is disclosed. The multi-dimensional gas chromatograph includes a first column, a second column, and a modulator disposed between the first column and the second column. The modulator modulates at (i) a first modulation period over a first time period during the run and (ii) a second modulation period over a second time period during the run later than the first time, the second modulation period being different than the first modulation period.

公开(公告)号：US20240310337A1

公开(公告)日：2024-09-19

申请号：US18263638

申请日：2022-01-11

Applicant: LECO Corporation

Inventor： Mark Firmer Merrick ,  David Jesse Borton

IPC: G01N30/72 ,  G01N30/02 ,  G01N30/10 ,  G01N30/32 ,  G01N30/46 ,  G01N30/68 ,  G01N30/78

CPC classification number: G01N30/7213 ,  G01N30/10 ,  G01N30/32 ,  G01N30/465 ,  G01N30/68 ,  G01N30/78 ,  G01N2030/025

Abstract: An analytical instrument assembly includes a gas chromatograph, a first detector, a second detector, and a pneumatic control module. The gas chromatograph includes a flow splitter configured to receive a sample. The first detector is coupled to the flow splitter. The second detector is coupled to the flow splitter. The pneumatic control module is coupled to the flow splitter and configured to deliver a carrier gas to the flow splitter. The flow splitter is configured to split the sample and deliver at least a first portion of the sample to the first detector and at least a second portion of the sample to the second detector at a first split ratio. The pneumatic control module is configured to deliver one of (i) a makeup flow including a third portion of the carrier gas to the flow splitter or (ii) an exhaust flow out of the flow splitter, wherein the pneumatic control module is configured to regulate the pressure within the flow splitter to thereby maintain the first split ratio at a substantially constant value.

公开(公告)号：US20200041466A1

公开(公告)日：2020-02-06

申请号：US16441603

申请日：2017-12-13

Applicant: LECO Corporation

Inventor： Mark Firmer Merrick

IPC: G01N30/30 ,  G01N30/46 ,  G01N30/54 ,  G01N30/12

Abstract: A chromatography system includes a modulator, a chromatograph, a cooler, and a detector. The chromatograph is connected to the modulator by a first heated transfer line. The detector is connected to the modulator by a second heated transfer line. The cooler is connected to the modulator. The modulator is arranged outside of the chromatograph.

公开(公告)号：US12140576B2

公开(公告)日：2024-11-12

申请号：US18602959

申请日：2024-03-12

Applicant: LECO Corporation

Inventor： David Jesse Borton ,  Jonelle Ley Shiel ,  Mark Firmer Merrick

IPC: G01N30/46 ,  G01N30/16 ,  G01N30/88 ,  G01N30/02

Abstract: A multi-dimensional gas chromatograph for analyzing compounds in a sample during a single run is disclosed. The multi-dimensional gas chromatograph includes a first column, a second column, and a modulator disposed between the first column and the second column. The modulator modulates at (i) a first modulation period over a first time period during the run and (ii) a second modulation period over a second time period during the run later than the first time, the second modulation period being different than the first modulation period.

公开(公告)号：US20240053308A1

公开(公告)日：2024-02-15

申请号：US18348624

申请日：2023-07-07

Applicant: LECO Corporation

Inventor： Mark Firmer Merrick

IPC: G01N30/86 ,  G01N30/10 ,  G01N30/78

CPC classification number: G01N30/8631 ,  G01N30/10 ,  G01N30/78 ,  G01N30/8665 ,  G01N2030/025

Abstract: A method includes receiving respective first and second sets of detection data generated by first and second detectors of a gas chromatograph (GC) during a session and representative of chromatographic properties of first and second portions of an effluent delivered to the first and second detectors from first and second transfer lines of the GC. The method also includes receiving a temperature profile that identifies first and second temperature zones of the first and second portions of the effluent during the session. The second set of detection data is misaligned relative to the first set along a time axis. The method also includes applying an alignment profile to the second set to align the first and second sets along the time axis. The alignment profile is based on the temperature profile.

公开(公告)号：US20220326196A1

公开(公告)日：2022-10-13

申请号：US17809330

申请日：2022-06-28

Applicant: LECO Corporation

Inventor： Mark Firmer Merrick

IPC: G01N30/30 ,  G01N30/12 ,  G01N30/46 ,  G01N30/54

Abstract: A chromatography system includes a modulator, a chromatograph, a cooler, and a detector. The chromatograph is connected to the modulator by a first heated transfer line. The detector is connected to the modulator by a second heated transfer line. The cooler is connected to the modulator. The modulator is arranged outside of the chromatograph.

公开(公告)号：US20240329013A1

公开(公告)日：2024-10-03

申请号：US18503699

申请日：2023-11-07

Applicant: LECO Corporation

Inventor： Gaetano Stallone ,  Mark Firmer Merrick

IPC: G01N30/30 ,  G01N30/46

CPC classification number: G01N30/30 ,  G01N2030/3023 ,  G01N2030/303 ,  G01N2030/3053 ,  G01N30/463 ,  G01N30/465

Abstract: A method for modulating analytes in a gaseous stream passing through a capillary, wherein the analytes are retained in a trapping zone of the capillary, or allowed to pass therethrough, based on certain conditions. The method includes, during a first time period, heating the trapping zone of the capillary to a first temperature to desorb analytes therewithin and allow the analytes to pass therethrough, and during a second time period, cooling the capillary to a second temperature that is sufficient to trap and focus the analytes within the trapping zone. During the first time period, the method also includes retaining heat at the capillary during to minimize the load on a cooling device thermally connected thereto, and during the second time period, selectively allowing thermal transfer toward the cooling device.

公开(公告)号：US12025595B2

公开(公告)日：2024-07-02

申请号：US17281929

申请日：2019-10-04

Applicant: LECO Corporation

Inventor： Gaetano Stallone ,  Mark Firmer Merrick

IPC: G01N30/30 ,  G01N30/46 ,  G01N30/62

CPC classification number: G01N30/30 ,  G01N2030/303 ,  G01N30/465 ,  G01N2030/623

Abstract: A thermal modulator for a chromatographic system includes a cooler, a thermal valve, a thermal buffer, a heater, and a capillary. The thermal valve thermally-engages the cooler. The thermal buffer thermally-engages the thermal valve. The heater thermally-engages the thermal buffer. The capillary thermally-engages the heater and is configured to transport an analyte in a first direction.

公开(公告)号：US11609212B2

公开(公告)日：2023-03-21

申请号：US17809330

申请日：2022-06-28

Applicant: LECO Corporation

Inventor： Mark Firmer Merrick

IPC: G01N30/30 ,  G01N30/12 ,  G01N30/46 ,  G01N30/54 ,  G01N30/02

Abstract: A method for applying a heating sequence for a modulator includes, during a first period of time, heating a first heating zone disposed along a length of the modulator without heating a second heating zone to cause a sample trapped from a first transfer line at an entrance of the modulator to move from the first heating zone to the second heating zone. The method also includes, during a second time period, withdrawing the heating of the first heating zone to prevent the sample from entering the modulator from the first transfer line. During a third time period, the method includes heating the second heating zone without heating the first heating zone to reinject the sample into a second transfer line.