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    Process for producing DL-phenylalanine
    2.
    发明授权
    Process for producing DL-phenylalanine 失效
    生产DL-苯丙氨酸的方法

    公开(公告)号：US4704471A

    公开(公告)日：1987-11-03

    申请号：US854709

    申请日：1986-04-23

    申请人： Tuneo Harada ,  Kiyotaka Oyama

    发明人： Tuneo Harada ,  Kiyotaka Oyama

    IPC分类号： C07C67/00 ,  C07C227/00 ,  C07C227/08 ,  C07C229/36 ,  C07C99/00

    CPC分类号： C07C227/08

    摘要： A process for producing DL-phenylalanine by reacting an .alpha.-halogeno-.beta.-phenylpropionic acid represented by the general formula: ##STR1## where X is a halogen atom, or its salt, with ammonia, characterized in that the reaction is conducted while supplying the .alpha.-halogeno-.beta.-phenylpropionic acid or its salt into aqueous ammonia charged in a reactor in advance.

    摘要翻译： 通过使由以下通式表示的α-卤代-β-苯基丙酸（其中X是卤素原子）或其盐与氨反应生成DL-苯丙氨酸的方法，其特征在于反应是 在将α-卤代-β-苯基丙酸或其盐预先提供在反应器中的氨水中进行。

    Process for producing an addition compound of a dipeptide ester and an amino acid ester
    7.
    发明授权
    Process for producing an addition compound of a dipeptide ester and an amino acid ester 失效
    制备二肽酯和氨基酸酯的加成化合物的方法

    公开(公告)号：US4521514A

    公开(公告)日：1985-06-04

    申请号：US516344

    申请日：1983-07-22

    申请人： Kiyotaka Oyama ,  Shigeaki Irino ,  Tsuneo Harada ,  Masao Nakamura

    发明人： Kiyotaka Oyama ,  Shigeaki Irino ,  Tsuneo Harada ,  Masao Nakamura

    IPC分类号： C12P21/02 ,  C07K5/06 ,  C07K5/072 ,  C07K5/075 ,  C07C103/52

    CPC分类号： C07K5/0613

    摘要： A process for producing an addition compound of N-benzyloxycarbonyl-.alpha.-L-aspartyl-L-phenylalanine methyl ester and phenylalanine methyl ester. Benzyloxycarbonylation of the amino group of L-aspartic acid by benzyloxycarbonylchloride in the presence of a base and esterification of phenylalanine containing its L-body by methanol in the presence of an acid are carried out and both the reaction solutions are admixed after residual methanol is removed from the esterification reaction solution. A proteolytic enzyme is added to the resulting mixture solution after it is adjusted to have a pH, value, at which no substantial deactivation of the enzyme occurs. The reaction of N-benzyloxycarbonyl-L-aspartic acid and phenylalanine methyl ester is carried out in the solution at a pH, at which the proteolytic enzyme exerts the enzymatic activity to deposit the addition compound which is then recovered.

    摘要翻译： 制备N-苄氧羰基-α-L-天冬氨酰-L-苯丙氨酸甲酯和苯丙氨酸甲酯的加成化合物的方法。 苄基氧基羰基氯在碱存在下苄基氧基羰基化，苄基氧基羰基氯在碱的存在下苄基氧基羰基化，并在酸存在下用甲醇在酸的存在下酯化含有L-体的苯丙氨酸，并在残留的甲醇被除去后将两种反应溶液混合 从酯化反应溶液中。 在将所述混合溶液调节至具有不发生基本上的失活酶的pH值之后，将蛋白水解酶加入到所得混合溶液中。 N-苄氧羰基-L-天冬氨酸和苯丙氨酸甲酯的反应在溶液中在pH下进行，其中蛋白水解酶发挥酶活性以沉积加入的化合物，然后将其回收。

    Method for crystallizing .alpha.-L-aspartyl-L-phenylalanine methyl ester
    8.
    发明授权
    Method for crystallizing .alpha.-L-aspartyl-L-phenylalanine methyl ester 失效
    α-L-天冬氨酰-L-苯丙氨酸甲酯的结晶方法

    公开(公告)号：US5347035A

    公开(公告)日：1994-09-13

    申请号：US125193

    申请日：1993-09-23

    申请人： Hidetoshi Wakamatsu ,  Tsuneo Harada ,  Yukio Kunisawa ,  Kiyotaka Oyama

    发明人： Hidetoshi Wakamatsu ,  Tsuneo Harada ,  Yukio Kunisawa ,  Kiyotaka Oyama

    IPC分类号： A23L27/30 ,  C07K1/14 ,  C07K5/06 ,  C07K5/072 ,  C07K5/075 ,  C07C229/00

    CPC分类号： C07K5/0613

    摘要： A method for crystallizing .alpha.-L-aspartyl-L-phenylalanine methyl ester from a hot aqueous solution containing .alpha.-L-aspartyl-L-phenylalanine methyl ester by cooling is disclosed, which comprises (i) continuously supplying a hot aqueous solution of .alpha.-L-aspartyl-L-phenylalanine methyl ester having a concentration such that the content of L-aspartyl-L-aspartyl-L-phenylalanine methyl esters is less than 0.6% by weight based on the weight of .alpha.-L-aspartyl-L-phenylalanine methyl ester in said solution, or if the content of L-aspartyl-L-aspartyl-L-phenylalanine methyl esters is 0.6% by weight or more based on the weight of .alpha.-L-aspartyl-L-phenylalanine methyl ester in said solution, to a crystallization vessel the temperature of which is lowered to that corresponding to the solubility of .alpha.-L-aspartyl-L-phenylalanine methyl ester or less, and (ii) continuously discharging the formed slurry from the crystallization vessel.

    摘要翻译： 公开了一种通过冷却从含有α-L-天冬氨酰-L-苯丙氨酸甲酯的热水溶液中结晶α-L-天冬氨酰基-L-苯丙氨酸甲酯的方法，其包括（i）连续供应热的α水溶液 L-天冬氨酰-L-苯丙氨酸甲酯的浓度使得L-天冬氨酰基-L-天冬氨酰基-L-苯丙氨酸甲酯的含量基于α-L-天冬氨酰-L重量的小于0.6重量％ - 苯丙氨酸甲酯，或者如果L-天冬氨酰基-L-天冬氨酰基-L-苯丙氨酸甲酯的含量基于α-L-天冬氨酰基-L-苯丙氨酸甲酯的重量计为0.6重量％以上 所述溶液加到结晶容器中，该结晶容器的温度降低至与α-L-天冬氨酰基-L-苯丙氨酸甲酯的溶解度或更低的溶解度，和（ii）从结晶容器中连续排出形成的浆料。